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Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens , Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

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Listed:
  • Marcela González-Gross

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
    CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain)

  • Carlos Quesada-González

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
    Department of Applied Mathematics to Information and Communication Technologies, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

  • Javier Rueda

    (Biomechanical Laboratory, Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

  • Manuel Sillero-Quintana

    (Department of Sport, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

  • Nicolas Issaly

    (Natural Origins, 69380 Lozanne, France)

  • Angel Enrique Díaz

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
    Clinical Laboratory Unit, Department of Sport and Health, Spanish Agency for Health Protection in Sport (AEPSAD), 28040 Madrid, Spain)

  • Eva Gesteiro

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

  • David Escobar-Toledo

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

  • Rafael Torres-Peralta

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

  • Marc Roller

    (Natural Origins, 69380 Lozanne, France)

  • Amelia Guadalupe-Grau

    (ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain)

Abstract

Recreational running (RR) is becoming a popular way to increase physical activity for improving health, together with a higher incidence of knee injuries. The aim was to analyze the effect of a four-week supplementation with a mixture of Harpagophytum procumbens , Zingiber officinale and Bixa orellana on males, middle-aged, RR with an undiagnosed knee discomfort. A randomized triple-blind placebo-control trial was conducted among male RR aged 40–60 years suffering from self-declared knee discomfort after training. Participants were assigned to supplementation (2 g/day in 6 doses; n = 13; intervention group (IG)) or matched placebo ( n = 15; control group (CG)) for 4 weeks. At pre- and post-intervention, assessment of routine blood biomarkers, body composition, running biomechanics and body temperature was performed using standardized procedures. Machine learning (ML) techniques were used to classify whether subjects belonged to IG or CG. ML model was able to correctly classify individuals as IG or CG with a median accuracy of 0.857. Leg fat mass decreased significantly ( p = 0.037) and a deeper reduction in knee thermograms was observed in IG ( p < 0.05). Safety evaluation revealed no significant differences in the rest of parameters studied. Subjects belonging to IG or CG are clearly differentiated, pointing into an effect of the supplement of ameliorating inflammation.

Suggested Citation

  • Marcela González-Gross & Carlos Quesada-González & Javier Rueda & Manuel Sillero-Quintana & Nicolas Issaly & Angel Enrique Díaz & Eva Gesteiro & David Escobar-Toledo & Rafael Torres-Peralta & Marc Rol, 2021. "Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens , Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, ," IJERPH, MDPI, vol. 18(11), pages 1-18, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5538-:d:559915
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    References listed on IDEAS

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    1. Kuhn, Max, 2008. "Building Predictive Models in R Using the caret Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 28(i05).
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    1. Hamilton H. T. Reis & Ciro J. Brito & Manuel Sillero-Quintana & Alisson G. Silva & Ismael Fernández-Cuevas & Matheus S. Cerqueira & Francisco Z. Werneck & João C. B. Marins, 2023. "Can Adipose Tissue Influence the Evaluation of Thermographic Images in Adolescents?," IJERPH, MDPI, vol. 20(5), pages 1-11, March.

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