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Association between Statin Use and Balance in Older Adults

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  • Antoine Langeard

    (Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada
    Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    EPIC Center, Montreal Heart Institute and University of Montreal, Montreal, QC H1T 1N6, Canada
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada)

  • Kathia Saillant

    (Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada
    Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    EPIC Center, Montreal Heart Institute and University of Montreal, Montreal, QC H1T 1N6, Canada
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada)

  • Elisabeth Charlebois Cloutier

    (Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada
    Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    EPIC Center, Montreal Heart Institute and University of Montreal, Montreal, QC H1T 1N6, Canada
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada)

  • Mathieu Gayda

    (Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    EPIC Center, Montreal Heart Institute and University of Montreal, Montreal, QC H1T 1N6, Canada
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada)

  • Frédéric Lesage

    (Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada
    Department of Electrical Engineering, Polytechnique Montreal, Montreal, QC H3T 1J4, Canada)

  • Anil Nigam

    (Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    EPIC Center, Montreal Heart Institute and University of Montreal, Montreal, QC H1T 1N6, Canada
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada)

  • Louis Bherer

    (Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada
    Department of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
    EPIC Center, Montreal Heart Institute and University of Montreal, Montreal, QC H1T 1N6, Canada
    Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada)

  • Sarah A. Fraser

    (Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, QC H3W 1W5, Canada
    Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada)

Abstract

Background: Several medications have been associated with an increased risk of balance deficits and greater likelihood to sustain a fall, representing a large health and economic issue. Statins are regularly prescribed to prevent strokes and heart attacks, but their impact on balance is unknown. The aim of this paper was to determine whether statin use is associated with poorer balance performances in older adults. Methods: All participants, one group taking statins (n = 34), and the other group not taking statins (n = 31), completed a balance assessment with their eyes closed and their eyes opened on a MatScan Pressure Sensing Mat. Center of Pressure (CoP) velocity, peak-to-peak distance, and standard deviation were collected in both anteroposterior (AP) and mediolateral (ML) directions. Multiple linear regression analyses were performed for each balance outcome, testing the statin use status as a predictor and controlling for appropriate factors including participants characteristics, lipid profile, and cardiovascular disease. Results: After controlling for confounding factors, statin use significantly predicted both CoP ML-Amplitude (β = 0.638, p = 0.004) and ML-Velocity (β = 0.653, p = 0.002) in the eyes-opened condition. Conclusions: The present study detected a negative association between statin use and balance control in the ML direction, suggesting that caution should be taken when prescribing statins in older adults, as this could decrease ML stability and ultimately increase fall and fracture risks.

Suggested Citation

  • Antoine Langeard & Kathia Saillant & Elisabeth Charlebois Cloutier & Mathieu Gayda & Frédéric Lesage & Anil Nigam & Louis Bherer & Sarah A. Fraser, 2020. "Association between Statin Use and Balance in Older Adults," IJERPH, MDPI, vol. 17(13), pages 1-9, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4662-:d:377583
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    References listed on IDEAS

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    1. Satariano, W.A. & Guralnik, J.M. & Jackson, R.J. & Marottoli, R.A. & Phelan, E.A. & Prohaska, T.R., 2012. "Mobility and aging: New directions for public health action," American Journal of Public Health, American Public Health Association, vol. 102(8), pages 1508-1515.
    2. Atanu Sengupta & Sanjoy De, 2020. "Review of Literature," India Studies in Business and Economics, in: Assessing Performance of Banks in India Fifty Years After Nationalization, chapter 0, pages 15-30, Springer.
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