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Multicomponent Exercise Program Reduces Frailty and Inflammatory Biomarkers and Improves Physical Performance in Community-Dwelling Older Adults: A Randomized Controlled Trial

Author

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  • Uratcha Sadjapong

    (Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Supachai Yodkeeree

    (Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Somporn Sungkarat

    (Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Penprapa Siviroj

    (Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

Abstract

The efficacy of exercise to reverse frailty in the aging population has not been extensively investigated. This study aimed to investigate the effectiveness of a multicomponent exercise program (MCEP) on frailty, physical performance (handgrip strength, Berg Balance Scale (BBS), Timed Up and Go test (TUG), and VO 2 Max), blood biomarkers (Interleukin-6 (IL-6) and C-reactive protein (CRP)) in frail older adults. A randomized controlled trial using an allocation concealment method, included 64 older adults (77.78 ± 7.24 years), were divided into two parallel groups using block randomization: an MCEP group ( n = 32) and a control group ( n = 32). The combined center- and home-based MCEP training consisted of chair aerobic, resistance, and balance, which was carried out 3 days per week for 24 weeks. A mixed model repeated measure ANOVA demonstrated significant interaction effects of group x time for BBS, TUG and frailty scores ( p < 0.001). Additionally, the post-hoc analysis revealed that the MCEP group showed significantly improved BBS, TUG, and frailty scores ( p < 0.01), at both 12- and 24-weeks. When compared with controls at 12-weeks, the MCEP group decreased IL-6 and CRP levels ( p < 0.05). The combined center- and home-based MCEP were effective in reversing frailty to pre-frailty and improving physical performance especially balance in the older population.

Suggested Citation

  • Uratcha Sadjapong & Supachai Yodkeeree & Somporn Sungkarat & Penprapa Siviroj, 2020. "Multicomponent Exercise Program Reduces Frailty and Inflammatory Biomarkers and Improves Physical Performance in Community-Dwelling Older Adults: A Randomized Controlled Trial," IJERPH, MDPI, vol. 17(11), pages 1-15, May.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:3760-:d:363053
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    References listed on IDEAS

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    1. Youn-Jung Son & Kyounghoon Lee & Bo-Hwan Kim, 2019. "Gender Differences in the Association between Frailty, Cognitive Impairment, and Self-Care Behaviors Among Older Adults with Atrial Fibrillation," IJERPH, MDPI, vol. 16(13), pages 1-12, July.
    2. Mathuramat Seesen & Warathit Semmarath & Supachai Yodkeeree & Ratana Sapbamrer & Pisittawoot Ayood & Rungnapa Malasao & Krongporn Ongprasert & Jiraporn Chittrakul & Penprapa Siviroj & Pornngarm Limtra, 2020. "Combined Black Rice Germ, Bran Supplement and Exercise Intervention Modulate Aging Biomarkers and Improve Physical Performance and Lower-Body Muscle Strength Parameters in Aging Population," IJERPH, MDPI, vol. 17(8), pages 1-22, April.
    3. Warathit Semmarath & Mathuramat Seesen & Supachai Yodkeeree & Ratana Sapbamrer & Pisittawoot Ayood & Rungnapa Malasao & Penprapa Siviroj & Pornngarm Limtrakul (Dejkriengkraikul), 2019. "The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand," IJERPH, MDPI, vol. 16(18), pages 1-15, September.
    4. Jiraporn Chittrakul & Penprapa Siviroj & Somporn Sungkarat & Ratana Sapbamrer, 2020. "Multi-System Physical Exercise Intervention for Fall Prevention and Quality of Life in Pre-Frail Older Adults: A Randomized Controlled Trial," IJERPH, MDPI, vol. 17(9), pages 1-13, April.
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    2. Marianna De Maio & Cecilia Bratta & Alice Iannaccone & Loriana Castellani & Carl Foster & Cristina Cortis & Andrea Fusco, 2022. "Home-Based Physical Activity as a Healthy Aging Booster before and during COVID-19 Outbreak," IJERPH, MDPI, vol. 19(7), pages 1-19, April.
    3. Luis Llurda-Almuzara & Jacobo Rodríguez-Sanz & Carlos López-de-Celis & Ramón Aiguadé-Aiguadé & Raúl Arán-Jové & Noé Labata-Lezaun & César Fernández-de-las-Peñas & Joan Bosch & Albert Pérez-Bellmunt, 2022. "Effects of Adding an Online Exercise Program on Physical Function in Individuals Hospitalized by COVID-19: A Randomized Controlled Trial," IJERPH, MDPI, vol. 19(24), pages 1-12, December.
    4. Chen-Yi Song & Pay-Shin Lin & Pei-Lun Hung & ADLers Occupational Therapy Clinic, 2021. "Effects of Community-Based Physical-Cognitive Training, Health Education, and Reablement among Rural Community-Dwelling Older Adults with Mobility Deficits," IJERPH, MDPI, vol. 18(17), pages 1-10, September.
    5. Jason R. Falvey & Joanna Z. Ye & Elizabeth A. Parker & Brock A. Beamer & Odessa Addison, 2022. "Rehabilitation Outcomes among Frail Older Adults in the United States," IJERPH, MDPI, vol. 19(17), pages 1-10, September.
    6. Deyu Meng & Hongzhi Guo & Siyu Liang & Zhibo Tian & Ran Wang & Guang Yang & Ziheng Wang, 2022. "Effectiveness of a Hybrid Exercise Program on the Physical Abilities of Frail Elderly and Explainable Artificial-Intelligence-Based Clinical Assistance," IJERPH, MDPI, vol. 19(12), pages 1-15, June.
    7. Emilio Jofré-Saldía & Álvaro Villalobos-Gorigoitía & Cristián Cofré-Bolados & Gerson Ferrari & Gemma María Gea-García, 2023. "Multicomponent Training in Progressive Phases Improves Functional Capacity, Physical Capacity, Quality of Life, and Exercise Motivation in Community-Dwelling Older Adults: A Randomized Clinical Trial," IJERPH, MDPI, vol. 20(3), pages 1-24, February.
    8. Gloria Cecilia Vega-Ávila & Diego Fernando Afanador-Restrepo & Yulieth Rivas-Campo & Patricia Alexandra García-Garro & Fidel Hita-Contreras & María del Carmen Carcelén-Fraile & Yolanda Castellote-Caba, 2022. "Rhythmic Physical Activity and Global Cognition in Older Adults with and without Mild Cognitive Impairment: A Systematic Review," IJERPH, MDPI, vol. 19(19), pages 1-16, September.

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