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The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults

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Listed:
  • Harrington, Karra D.
  • Dang, Christa
  • Lim, Yen Ying
  • Ames, David
  • Laws, Simon M.
  • Pietrzak, Robert H.
  • Rainey-Smith, Stephanie
  • Robertson, Joanne
  • Rowe, Christopher C.
  • Salvado, Olivier
  • Villemagne, Victor L.
  • Masters, Colin L.
  • Maruff, Paul

Abstract

It is possible that estimates of normal age-related decline in intellectual function have been biased negatively by undetected preclinical Alzheimer's disease (AD). This prospective study aimed to determine the nature and magnitude of changes in crystallized and fluid intelligence, as well as their relationship to one another, in normal aging, taking into account the effects of preclinical AD.

Suggested Citation

  • Harrington, Karra D. & Dang, Christa & Lim, Yen Ying & Ames, David & Laws, Simon M. & Pietrzak, Robert H. & Rainey-Smith, Stephanie & Robertson, Joanne & Rowe, Christopher C. & Salvado, Olivier & Vill, 2018. "The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults," Intelligence, Elsevier, vol. 70(C), pages 22-29.
  • Handle: RePEc:eee:intell:v:70:y:2018:i:c:p:22-29
    DOI: 10.1016/j.intell.2018.07.004
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    References listed on IDEAS

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    1. Bates, Douglas & Mächler, Martin & Bolker, Ben & Walker, Steve, 2015. "Fitting Linear Mixed-Effects Models Using lme4," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 67(i01).
    2. Patrick Rabbitt & Peter Diggle & Fiona Holland & Lynn McInnes, 2004. "Practice and Drop-Out Effects During a 17-Year Longitudinal Study of Cognitive Aging," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 59(2), pages 84-97.
    3. Scharfen, Jana & Peters, Judith Marie & Holling, Heinz, 2018. "Retest effects in cognitive ability tests: A meta-analysis," Intelligence, Elsevier, vol. 67(C), pages 44-66.
    4. Nicole D. Anderson & Fergus I. M. Craik, 2017. "50 Years of Cognitive Aging Theory," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 72(1), pages 1-6.
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    Cited by:

    1. Bruton, Oliver J., 2021. "Is there a “g-neuron”? Establishing a systematic link between general intelligence (g) and the von Economo neuron," Intelligence, Elsevier, vol. 86(C).

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