A semiparametric accelerated failure time partial linear model and its application to breast cancer
Breast cancer is the most common non-skin cancer in women and the second most common cause of cancer-related death in US women. It is well known that the breast cancer survival rate varies with age at diagnosis. For most cancers, the relative survival rate decreases with age, but breast cancer may show an unusual age pattern. In order to reveal the stage risk and age effects pattern, we propose a semiparametric accelerated failure time partial linear model and develop its estimation method based on the penalized spline (P-spline) and the rank estimation approach. The simulation studies demonstrate that the proposed method is comparable to the parametric approach when data is not contaminated, and more stable than parametric methods when data is contaminated. By applying the proposed model and method to the breast cancer data set of Atlantic County, New Jersey, from the SEER program, we successfully reveal the significant effects of stage, and show that women diagnosed at age around 38 years have consistently higher survival rates than either younger or older women.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Brent A. Johnson, 2008. "Variable selection in semiparametric linear regression with censored data," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(2), pages 351-370.
- Cai, Jianwen & Fan, Jianqing & Jiang, Jiancheng & Zhou, Haibo, 2007. "Partially Linear Hazard Regression for Multivariate Survival Data," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 538-551, June.
- Jianhua Z. Huang & Liangyue Zhang & Lan Zhou, 2007. "Efficient Estimation in Marginal Partially Linear Models for Longitudinal/Clustered Data Using Splines," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 34(3), pages 451-477.
- Xuming He, 2002. "Estimation in a semiparametric model for longitudinal data with unspecified dependence structure," Biometrika, Biometrika Trust, vol. 89(3), pages 579-590, August.
- Zhezhen Jin, 2003. "Rank-based inference for the accelerated failure time model," Biometrika, Biometrika Trust, vol. 90(2), pages 341-353, June.
- Lin X. & Carroll R. J., 2001. "Semiparametric Regression for Clustered Data Using Generalized Estimating Equations," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1045-1056, September.
- T. Cai & J. Huang & L. Tian, 2009. "Regularized Estimation for the Accelerated Failure Time Model," Biometrics, The International Biometric Society, vol. 65(2), pages 394-404, 06.
- Yu Y. & Ruppert D., 2002. "Penalized Spline Estimation for Partially Linear Single-Index Models," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 1042-1054, December.
- Zhezhen Jin & D. Y. Lin & Zhiliang Ying, 2006. "On least-squares regression with censored data," Biometrika, Biometrika Trust, vol. 93(1), pages 147-161, March.
- Zeng, Donglin & Lin, D.Y., 2007. "Efficient Estimation for the Accelerated Failure Time Model," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 1387-1396, December.
When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:55:y:2011:i:3:p:1479-1487. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei)
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If references are entirely missing, you can add them using this form.
If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.
Please note that corrections may take a couple of weeks to filter through the various RePEc services.