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On least-squares regression with censored data


  • Zhezhen Jin
  • D. Y. Lin
  • Zhiliang Ying


The semiparametric accelerated failure time model relates the logarithm of the failure time linearly to the covariates while leaving the error distribution unspecified. The present paper describes simple and reliable inference procedures based on the least-squares principle for this model with right-censored data. The proposed estimator of the vector-valued regression parameter is an iterative solution to the Buckley--James estimating equation with a preliminary consistent estimator as the starting value. The estimator is shown to be consistent and asymptotically normal. A novel resampling procedure is developed for the estimation of the limiting covariance matrix. Extensions to marginal models for multivariate failure time data are considered. The performance of the new inference procedures is assessed through simulation studies. Illustrations with medical studies are provided. Copyright 2006, Oxford University Press.

Suggested Citation

  • Zhezhen Jin & D. Y. Lin & Zhiliang Ying, 2006. "On least-squares regression with censored data," Biometrika, Biometrika Trust, vol. 93(1), pages 147-161, March.
  • Handle: RePEc:oup:biomet:v:93:y:2006:i:1:p:147-161

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    References listed on IDEAS

    1. Eric Schoen, 1999. "Designing fractional two-level experiments with nested error structures," Journal of Applied Statistics, Taylor & Francis Journals, vol. 26(4), pages 495-508.
    2. C. J. Brien & R. A. Bailey, 2006. "Multiple randomizations," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(4), pages 571-609.
    3. GOOS, Peter, "undated". "The usefulness of optimal design for generating blocked and split-plot response surface experiments," Working Papers 2005033, University of Antwerp, Faculty of Applied Economics.
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    Cited by:

    1. Yu, Lili & Peace, Karl E., 2012. "Spline nonparametric quasi-likelihood regression within the frame of the accelerated failure time model," Computational Statistics & Data Analysis, Elsevier, vol. 56(9), pages 2675-2687.
    2. Chen, Pengcheng & Zhang, Jiajia & Zhang, Riquan, 2013. "Estimation of the accelerated failure time frailty model under generalized gamma frailty," Computational Statistics & Data Analysis, Elsevier, vol. 62(C), pages 171-180.
    3. Changrong Yan & Dixin Zhang, 2013. "Sparse dimension reduction for survival data," Computational Statistics, Springer, vol. 28(4), pages 1835-1852, August.
    4. Wang, Xiaoguang & Shi, Xinyong, 2014. "Robust estimation for survival partially linear single-index models," Computational Statistics & Data Analysis, Elsevier, vol. 80(C), pages 140-152.
    5. Xie, Shangyu & Wan, Alan T.K. & Zhou, Yong, 2015. "Quantile regression methods with varying-coefficient models for censored data," Computational Statistics & Data Analysis, Elsevier, vol. 88(C), pages 154-172.
    6. Xu, Linzhi & Zhang, Jiajia, 2010. "An EM-like algorithm for the semiparametric accelerated failure time gamma frailty model," Computational Statistics & Data Analysis, Elsevier, vol. 54(6), pages 1467-1474, June.
    7. Jin, Zhezhen & He, Wenqing, 2016. "Local linear regression on correlated survival data," Journal of Multivariate Analysis, Elsevier, vol. 147(C), pages 285-294.
    8. Emily A. Scherer & Lin Huang & Lydia A. Shrier, 2017. "Application of Correlated Time-to-Event Models to Ecological Momentary Assessment Data," Psychometrika, Springer;The Psychometric Society, vol. 82(1), pages 233-244, March.
    9. Zou, Yubo & Zhang, Jiajia & Qin, Guoyou, 2011. "A semiparametric accelerated failure time partial linear model and its application to breast cancer," Computational Statistics & Data Analysis, Elsevier, vol. 55(3), pages 1479-1487, March.
    10. Lu, Xuewen, 2010. "Asymptotic distributions of two "synthetic data" estimators for censored single-index models," Journal of Multivariate Analysis, Elsevier, vol. 101(4), pages 999-1015, April.
    11. Bao, Yanchun & He, Shuyuan & Mei, Changlin, 2007. "The Koul-Susarla-Van Ryzin and weighted least squares estimates for censored linear regression model: A comparative study," Computational Statistics & Data Analysis, Elsevier, vol. 51(12), pages 6488-6497, August.
    12. repec:eee:stapro:v:131:y:2017:i:c:p:51-55 is not listed on IDEAS
    13. Zhang, Jiajia & Peng, Yingwei, 2009. "Crossing hazard functions in common survival models," Statistics & Probability Letters, Elsevier, vol. 79(20), pages 2124-2130, October.
    14. Wang, You-Gan & Fu, Liya, 2011. "Rank regression for accelerated failure time model with clustered and censored data," Computational Statistics & Data Analysis, Elsevier, vol. 55(7), pages 2334-2343, July.
    15. Jung-Yu Cheng & Shinn-Jia Tzeng, 2014. "Quantile regression of right-censored length-biased data using the Buckley–James-type method," Computational Statistics, Springer, vol. 29(6), pages 1571-1592, December.
    16. Zhou, Mai & Li, Gang, 2008. "Empirical likelihood analysis of the Buckley-James estimator," Journal of Multivariate Analysis, Elsevier, vol. 99(4), pages 649-664, April.

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