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Response of a ZrO2(Y)-memristive device to in vivo neuronal activity with abnormal oscillations

Author

Listed:
  • Koryazhkina, Maria N.
  • Lebedeva, Albina V.
  • Malkov, Anton E.
  • Guselnikova, Polina A.
  • Khabibulova, Vera A.
  • Pakhomova, Darina D.
  • Antonov, Ivan N.
  • Belov, Alexey I.
  • Agarkov, Yury Yu.
  • Mikhaylov, Alexey N.
  • Valenti, Davide

Abstract

The paper describes the results of a study of the effect of neuronal activity with abnormal oscillations, obtained in vivo from epileptic animals, at different parameters (amplitude and constant offset) on the resistive state and response of a ZrO2(Y)-based memristive device. Epilepsy was modeled using the lithium-pilocarpine model – an approach that is believed to induce the emergence of chronic epilepsy and imitates with good accuracy the peculiarities in neuronal activity from humans with temporal lobe epilepsy. The study of the influence of these particular features – abnormal oscillations, in the form of waveform of the voltage applied to the memristive device – is carried out in this paper. Neuronal activity has been shown to change the resistive state of a memristive device. The memristive device, in turn, will almost not distort the frequency characteristics of the neuronal activity transmitted through it, which is crucial because brain activities are believed to manifest as rhythms across various frequencies. The mentioned above parameters play a key role in this change and are essential for tuning wearable devices – neuroprosthetic, designed to detect and suppress abnormal oscillations in neuronal activity in real time. Moreover, the paper demonstrates that the memristive device can be used to analyze large volumes of electrophysiological data with increased accuracy and processing speed, due to a well-known effect called the «voltage-time dilemma».

Suggested Citation

  • Koryazhkina, Maria N. & Lebedeva, Albina V. & Malkov, Anton E. & Guselnikova, Polina A. & Khabibulova, Vera A. & Pakhomova, Darina D. & Antonov, Ivan N. & Belov, Alexey I. & Agarkov, Yury Yu. & Mikhay, 2026. "Response of a ZrO2(Y)-memristive device to in vivo neuronal activity with abnormal oscillations," Chaos, Solitons & Fractals, Elsevier, vol. 205(C).
    • Handle: RePEc:eee:chsofr:v:205:y:2026:i:c:s096007792501803x
    DOI: 10.1016/j.chaos.2025.117789
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