IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v189y2024ip1s0960077924011871.html
   My bibliography  Save this article

Modulating propagation of Parkinsonian beta oscillations with transcranial direct current stimulation: A computational study

Author

Listed:
  • Wang, Xiaomin
  • Yu, Ying
  • Wang, Qingyun

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive technique that primarily modulates cortical excitatory (E) neurons. Anodal tDCS targeting the motor cortex alleviates symptoms in Parkinson's disease patients, but the regulatory mechanisms remain obscure, especially for parkinsonian β band (13–30 Hz) oscillations. To explore these regulatory mechanisms, we propose a more refined model of the cortex-thalamic-basal ganglia (CTBG) neuronal network, with the primary issue of elucidating the impact of cortical neurons, as targets of tDCS, on parkinsonian β oscillations. Through blocking pathways, β oscillations in basal ganglia propagate to cortex mainly through thalamocortical connections, supplemented by direct connections from Lim homeobox 6 globus pallidus externa to cortical neurons. Simulations of two scenarios that lead to abnormal intracortical β band firing suggest that intracortical β band firing in healthy state is insufficient to drive β oscillations in CTBG circuit. This emphasizes the cortex as a critical node for the propagation and enhancement of β oscillations in CTBG circuit. To reveal the intrinsic regulatory mechanism of tDCS, different tDCS strategies targeting cortical E neurons are further compared. Anodal tDCS disrupts the abnormal oscillatory activity in CTBG circuits by promoting the activity of cortical neurons and interrupting oscillation propagation. In addition, anodic tDCS can amplify rhythmic activity within the afferent cortex, thereby concealing pathological oscillations. These findings provide a theoretical basis for understanding the role of cortex in parkinsonian oscillations and provide a conceptual platform for theoretical testing of tDCS for clinical applications.

Suggested Citation

  • Wang, Xiaomin & Yu, Ying & Wang, Qingyun, 2024. "Modulating propagation of Parkinsonian beta oscillations with transcranial direct current stimulation: A computational study," Chaos, Solitons & Fractals, Elsevier, vol. 189(P1).
  • Handle: RePEc:eee:chsofr:v:189:y:2024:i:p1:s0960077924011871
    DOI: 10.1016/j.chaos.2024.115635
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077924011871
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.chaos.2024.115635?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Anli Liu & Mihály Vöröslakos & Greg Kronberg & Simon Henin & Matthew R. Krause & Yu Huang & Alexander Opitz & Ashesh Mehta & Christopher C. Pack & Bart Krekelberg & Antal Berényi & Lucas C. Parra & Lu, 2018. "Immediate neurophysiological effects of transcranial electrical stimulation," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Mihály Vöröslakos & Yuichi Takeuchi & Kitti Brinyiczki & Tamás Zombori & Azahara Oliva & Antonio Fernández-Ruiz & Gábor Kozák & Zsigmond Tamás Kincses & Béla Iványi & György Buzsáki & Antal Berényi, 2018. "Direct effects of transcranial electric stimulation on brain circuits in rats and humans," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    3. Arpiar Saunders & Ian A. Oldenburg & Vladimir K. Berezovskii & Caroline A. Johnson & Nathan D. Kingery & Hunter L. Elliott & Tiao Xie & Charles R. Gerfen & Bernardo L. Sabatini, 2015. "A direct GABAergic output from the basal ganglia to frontal cortex," Nature, Nature, vol. 521(7550), pages 85-89, May.
    4. Zhao, Jinyi & Yu, Ying & Wang, Qingyun, 2022. "Dynamical regulation of epileptiform discharges caused by abnormal astrocyte function with optogenetic stimulation," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    5. Leon A. Steiner & David Crompton & Srdjan Sumarac & Artur Vetkas & Jürgen Germann & Maximilian Scherer & Maria Justich & Alexandre Boutet & Milos R. Popovic & Mojgan Hodaie & Suneil K. Kalia & Alfonso, 2024. "Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Marie A. Labouesse & Arturo Torres-Herraez & Muhammad O. Chohan & Joseph M. Villarin & Julia Greenwald & Xiaoxiao Sun & Mysarah Zahran & Alice Tang & Sherry Lam & Jeremy Veenstra-VanderWeele & Clay O., 2023. "A non-canonical striatopallidal Go pathway that supports motor control," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Sean C. Piantadosi & Elizabeth E. Manning & Brittany L. Chamberlain & James Hyde & Zoe LaPalombara & Nicholas M. Bannon & Jamie L. Pierson & Vijay M. K Namboodiri & Susanne E. Ahmari, 2024. "Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Chen, Yixuan & Guo, Qun & Zhang, Xiaofeng & Wang, Chunni, 2024. "Numerical approach and physical description for a two-capacitive neuron and its adaptive network dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 189(P2).
    4. Wang, Zhizhi & Hu, Bing & Zhou, Weiting & Xu, Minbo & Wang, Dingjiang, 2023. "Hopf bifurcation mechanism analysis in an improved cortex-basal ganglia network with distributed delays: An application to Parkinson’s disease," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).
    5. Hu, Bing & Wang, Xingmei & Lu, Sixia & Ying, Xijian, 2025. "A study of bidirectional control of Parkinson’s beta oscillations by basal ganglia," Chaos, Solitons & Fractals, Elsevier, vol. 195(C).
    6. Qiaoqin Xiao & Zhenyu Zhong & Xiaozheng Lai & Huabiao Qin, 2019. "A multiple modulation synthesis method with high spatial resolution for noninvasive neurostimulation," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-15, June.
    7. Leon C Reteig & Lionel A Newman & K Richard Ridderinkhof & Heleen A Slagter, 2022. "Effects of tDCS on the attentional blink revisited: A statistical evaluation of a replication attempt," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-23, January.
    8. Mengyue Zhu & Jieqiao Peng & Mi Wang & Shan Lin & Huiying Zhang & Yu Zhou & Xinyue Dai & Huiying Zhao & Yan-qin Yu & Li Shen & Xiao-Ming Li & Jiadong Chen, 2025. "Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    9. Daria Antonenko & Anna Elisabeth Fromm & Friederike Thams & Ulrike Grittner & Marcus Meinzer & Agnes Flöel, 2023. "Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    10. Nicola Ria & Ahmed Eladly & Eduard Masvidal-Codina & Xavi Illa & Anton Guimerà & Kate Hills & Ramon Garcia-Cortadella & Fikret Taygun Duvan & Samuel M. Flaherty & Michal Prokop & Rob. C. Wykes & Kosta, 2025. "Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    11. Nicola Montemurro & Nelida Aliaga & Pablo Graff & Amanda Escribano & Jafeth Lizana, 2022. "New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review," IJERPH, MDPI, vol. 19(14), pages 1-18, July.
    12. Djeundam, S.R. Dtchetgnia & Filatrella, G. & Yamapi, R., 2018. "Desynchronization effects of a current-driven noisy Hindmarsh–Rose neural network," Chaos, Solitons & Fractals, Elsevier, vol. 115(C), pages 204-211.
    13. Giulio Ruffini & Ricardo Salvador & Ehsan Tadayon & Roser Sanchez-Todo & Alvaro Pascual-Leone & Emiliano Santarnecchi, 2020. "Realistic modeling of mesoscopic ephaptic coupling in the human brain," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-25, June.
    14. Varvara Mathiopoulou & Jeroen Habets & Lucia K. Feldmann & Johannes L. Busch & Jan Roediger & Jennifer K. Behnke & Gerd-Helge Schneider & Katharina Faust & Andrea A. Kühn, 2025. "Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    15. Harman Ghuman & Kyungsoo Kim & Sapeeda Barati & Karunesh Ganguly, 2023. "Emergence of task-related spatiotemporal population dynamics in transplanted neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    16. Miles Wischnewski & Harry Tran & Zhihe Zhao & Sina Shirinpour & Zachary J. Haigh & Jonna Rotteveel & Nipun D. Perera & Ivan Alekseichuk & Jan Zimmermann & Alexander Opitz, 2024. "Induced neural phase precession through exogenous electric fields," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    17. Lu, Qingchang & Farooq, Muhammad Umar & Ma, Xiaoyu & Iram, Robina, 2022. "Assessing the combining role of public-private investment as a green finance and renewable energy in carbon neutrality target," Renewable Energy, Elsevier, vol. 196(C), pages 1357-1365.
    18. Pedro G. Vieira & Matthew R. Krause & Christopher C. Pack, 2024. "Temporal interference stimulation disrupts spike timing in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:189:y:2024:i:p1:s0960077924011871. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.