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Uncertain pharmacokinetic model based on uncertain differential equation

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  • Liu, Z.
  • Yang, Y.

Abstract

Pharmacokinetics is the study of the time course of drug concentrations in body compartments. The majority of drugs are eliminated at first order kinetics with a nonconstant elimination rate due to spontaneous erratic variations in the metabolic processes and individual difference. Noting the paradox of stochastic pharmacokinetic models, this paper proposes an uncertain pharmacokinetic model for mono-compartmental drugs administered with intravenous administration based on uncertain differential equations. Uncertainty distributions, expected values and confidence intervals of the half-life and the area under the curve are provided. For this method to achieve its full potential, this paper derives moment estimations for unknown parameters in this uncertain pharmacokinetic model. Finally a numerical example and a real data analysis illustrate our methods.

Suggested Citation

  • Liu, Z. & Yang, Y., 2021. "Uncertain pharmacokinetic model based on uncertain differential equation," Applied Mathematics and Computation, Elsevier, vol. 404(C).
    • Handle: RePEc:eee:apmaco:v:404:y:2021:i:c:s0096300321001661
    DOI: 10.1016/j.amc.2021.126118
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    References listed on IDEAS

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    1. Yang, Xiangfeng & Ralescu, Dan A., 2015. "Adams method for solving uncertain differential equations," Applied Mathematics and Computation, Elsevier, vol. 270(C), pages 993-1003.
    2. Zhang, Yi & Gao, Jinwu & Huang, Zhiyong, 2017. "Hamming method for solving uncertain differential equations," Applied Mathematics and Computation, Elsevier, vol. 313(C), pages 331-341.
    3. Kai Yao & Baoding Liu, 2020. "Parameter estimation in uncertain differential equations," Fuzzy Optimization and Decision Making, Springer, vol. 19(1), pages 1-12, March.
    4. Liu, Z., 2021. "Generalized moment estimation for uncertain differential equations," Applied Mathematics and Computation, Elsevier, vol. 392(C).
    5. Yang, Xiangfeng & Liu, Yuhan & Park, Gyei-Kark, 2020. "Parameter estimation of uncertain differential equation with application to financial market," Chaos, Solitons & Fractals, Elsevier, vol. 139(C).
    6. Xiangfeng Yang & Kai Yao, 2017. "Uncertain partial differential equation with application to heat conduction," Fuzzy Optimization and Decision Making, Springer, vol. 16(3), pages 379-403, September.
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    Citations

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    Cited by:

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    2. Liu, Zhe & Li, Xiaoyang & Kang, Rui, 2022. "Uncertain differential equation based accelerated degradation modeling," Reliability Engineering and System Safety, Elsevier, vol. 225(C).
    3. Liu, Z. & Yang, Y., 2021. "Selection of uncertain differential equations using cross validation," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
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    8. Chen, Dan & Liu, Yang, 2023. "Uncertain Gordon-Schaefer model driven by Liu process," Applied Mathematics and Computation, Elsevier, vol. 450(C).

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