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Conditional Transformation Models for Survivor Function Estimation

Author

Listed:
  • Möst Lisa

    (LMU München, Institut für Statistik, München, Germany)

  • Hothorn Torsten

    (Institut für Sozial- und Präventivmedizin, Universität Zürich, Abteilung Biostatistik Hirschengraben 84, Zürich CH-8001, Switzerland)

Abstract

In survival analysis, the estimation of patient-specific survivor functions that are conditional on a set of patient characteristics is of special interest. In general, knowledge of the conditional survival probabilities of a patient at all relevant time points allows better assessment of the patient’s risk than summary statistics, such as median survival time. Nevertheless, standard methods for analysing survival data seldom estimate the survivor function directly. Therefore, we propose the application of conditional transformation models (CTMs) for the estimation of the conditional distribution function of survival times given a set of patient characteristics. We used the inverse probability of censoring weighting approach to account for right-censored observations. Our proposed modelling approach allows the prediction of patient-specific survivor functions. In addition, CTMs constitute a flexible model class that is able to deal with proportional as well as non-proportional hazards. The well-known Cox model is included in the class of CTMs as a special case. We investigated the performance of CTMs in survival data analysis in a simulation that included proportional and non-proportional hazard settings and different scenarios of explanatory variables. Furthermore, we re-analysed the survival times of patients suffering from chronic myelogenous leukaemia and studied the impact of the proportional hazards assumption on previously published results.

Suggested Citation

  • Möst Lisa & Hothorn Torsten, 2015. "Conditional Transformation Models for Survivor Function Estimation," The International Journal of Biostatistics, De Gruyter, vol. 11(1), pages 23-50, May.
  • Handle: RePEc:bpj:ijbist:v:11:y:2015:i:1:p:23-50:n:3
    DOI: 10.1515/ijb-2014-0006
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    References listed on IDEAS

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    1. Wang, Huixia Judy & Wang, Lan, 2009. "Locally Weighted Censored Quantile Regression," Journal of the American Statistical Association, American Statistical Association, vol. 104(487), pages 1117-1128.
    2. Lu Tian & David Zucker & L.J. Wei, 2005. "On the Cox Model With Time-Varying Regression Coefficients," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 172-183, March.
    3. James M. Robins & Dianne M. Finkelstein, 2000. "Correcting for Noncompliance and Dependent Censoring in an AIDS Clinical Trial with Inverse Probability of Censoring Weighted (IPCW) Log-Rank Tests," Biometrics, The International Biometric Society, vol. 56(3), pages 779-788, September.
    4. Thomas H. Scheike & Torben Martinussen, 2004. "On Estimation and Tests of Time‐Varying Effects in the Proportional Hazards Model," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 31(1), pages 51-62, March.
    5. Powell, James L., 1986. "Censored regression quantiles," Journal of Econometrics, Elsevier, vol. 32(1), pages 143-155, June.
    6. Donglin Zeng & D. Y. Lin, 2006. "Efficient estimation of semiparametric transformation models for counting processes," Biometrika, Biometrika Trust, vol. 93(3), pages 627-640, September.
    7. Torsten Hothorn & Thomas Kneib & Peter Bühlmann, 2014. "Conditional transformation models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 76(1), pages 3-27, January.
    8. Gneiting, Tilmann & Raftery, Adrian E., 2007. "Strictly Proper Scoring Rules, Prediction, and Estimation," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 359-378, March.
    9. Schmid, Matthias & Hothorn, Torsten, 2008. "Boosting additive models using component-wise P-Splines," Computational Statistics & Data Analysis, Elsevier, vol. 53(2), pages 298-311, December.
    10. Michael Schemper & Robin Henderson, 2000. "Predictive Accuracy and Explained Variation in Cox Regression," Biometrics, The International Biometric Society, vol. 56(1), pages 249-255, March.
    11. Honore, Bo & Khan, Shakeeb & Powell, James L., 2002. "Quantile regression under random censoring," Journal of Econometrics, Elsevier, vol. 109(1), pages 67-105, July.
    12. Spierdijk, Laura, 2008. "Nonparametric conditional hazard rate estimation: A local linear approach," Computational Statistics & Data Analysis, Elsevier, vol. 52(5), pages 2419-2434, January.
    13. Peng, Limin & Huang, Yijian, 2008. "Survival Analysis With Quantile Regression Models," Journal of the American Statistical Association, American Statistical Association, vol. 103, pages 637-649, June.
    14. Holger Dette & Stanislav Volgushev, 2008. "Non‐crossing non‐parametric estimates of quantile curves," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(3), pages 609-627, July.
    15. Kani Chen, 2002. "Semiparametric analysis of transformation models with censored data," Biometrika, Biometrika Trust, vol. 89(3), pages 659-668, August.
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