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On the Inflammation Theory of Cancer

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  • Alain L Fymat

    (International Institute of Medicine and Science, USA)

Abstract

A recent clinical trial on humans (CANTOS) aimed to test inflammation, one of the two major theories for cardiovascular diseases, the other theory being concerned with lipids. However, somewhat surprisingly, the trial provided some support for the inflammation theory of cancer and this result may overshadow the trial’s original aim. However, inflammation has long been linked to cancer. As a preface to the link between inflammation and cancer, I first review the trial and summarize its results within the context of secondary prevention and mechanism pathways. With different doses against placebo, the drug tested in the trial was Canakinumab, a monoclonal antibody that targets Interleukin-1β. From a personalized medicine’s perspective, the trial and its results point to the future of secondary prevention as the identification of which mechanistic pathway would be most beneficial for a given patient. From this viewpoint, inflammation today is very much analogous to the identification of cholesterol 30 years ago. We now need to distinguish those heart disease patients who have “residual cholesterol risk†from those who have “residual inflammatory risk†, or both. These two groups will require different, perhaps also simultaneous, interventions.

Suggested Citation

  • Alain L Fymat, 2017. "On the Inflammation Theory of Cancer," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 8(3), pages 59-65, December.
    • Handle: RePEc:adp:jctoij:v:8:y:2017:i:3:p:59-65
    DOI: 10.19080/CTOIJ.2017.08.555740
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    References listed on IDEAS

    as
    1. Alain L Fymat, 2017. "On Cancer’s Theories, True Nature and Possible Self-Eradication," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 7(2), pages 27-29, September.
    2. Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
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