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Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis

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  • Shuai Zhao
  • Dang Wu
  • Pin Wu
  • Zhen Wang
  • Jian Huang

Abstract

Background: IL–10 is an important immunosuppressive cytokine which is frequently elevated in tumor microenvironment. Some studies have reported that overexpression of serous IL–10 is correlated with worse outcome in patients with malignant tumor. Here, we conducted a meta-analysis to assess the prognostic impact of serous IL–10 expression in cancer patients. Methods: We searched PubMed and EBSCO for studies in evaluating the association of IL–10 expression—in serum and clinical outcome in cancer patients. Overall survival (OS) was the primary prognostic indicator and disease-free survival (DFS) was the secondary indicator. Extracted data were computed into odds ratios (ORs) and 95% confidence interval (CI) or a P value for survival at 1, 3 and 5 years. Pooled data were weighted using the Mantel–Haenszel Fixed-effect model. All statistical tests were two-sided. Results: A total of 1788 patients with cancer from 21 published studies were incorporated into this meta-analysis. High level of serum IL–10 was significantly associated with worse OS at 1-year (OR = 3.70, 95% CI = 2.81 to 4.87, P

Suggested Citation

  • Shuai Zhao & Dang Wu & Pin Wu & Zhen Wang & Jian Huang, 2015. "Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0139598
    DOI: 10.1371/journal.pone.0139598
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    References listed on IDEAS

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    1. Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
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