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Inflammation and cancer

Author

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  • Lisa M. Coussens

    (Cancer Research Institute, University of California
    University of California
    UCSF Comprehensive Cancer Center, University of California)

  • Zena Werb

    (University of California
    UCSF Comprehensive Cancer Center, University of California)

Abstract

Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.

Suggested Citation

  • Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
    • Handle: RePEc:nat:nature:v:420:y:2002:i:6917:d:10.1038_nature01322
    DOI: 10.1038/nature01322
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