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Genes and Genetics of Tuberculosis

Author

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  • Bhaswati Pandit

    (National Institute of Biomedical Genomics, India)

Abstract

Tuberculosis affects human life globally for long time. About one third of the world’s population is infected with the causal pathogen Mycobacterium tuberculosis but without presenting any clinical symptoms. The difference in clinical outcome of infection suggests that host genetic makeup is responsible for such variability. Attempts have been made to identify the underlying genes. In case of Mendelian susceptibility to mycobacterial disease (MSMD) a rare disease with immune-deficiency, mutations were identified in genes that impair IFN γ signaling pathway. Linkage studies have identified several loci but exact gene was never pinpointed.

Suggested Citation

  • Bhaswati Pandit, 2017. "Genes and Genetics of Tuberculosis," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 1(4), pages 99-104, May.
    • Handle: RePEc:adp:ijoprs:v:1:y:2017:i:4:p:99-104
    DOI: 10.19080/IJOPRS.2017.01.555567
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    References listed on IDEAS

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    1. Haiko Schurz & Michelle Daya & Marlo Möller & Eileen G Hoal & Muneeb Salie, 2015. "TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-24, October.
    2. Matthew P. R. Berry & Christine M. Graham & Finlay W. McNab & Zhaohui Xu & Susannah A. A. Bloch & Tolu Oni & Katalin A. Wilkinson & Romain Banchereau & Jason Skinner & Robert J. Wilkinson & Charles Qu, 2010. "An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis," Nature, Nature, vol. 466(7309), pages 973-977, August.
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