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Comparative miRNA Expression Profiles in Individuals with Latent and Active Tuberculosis

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  • Chuan Wang
  • Shunyao Yang
  • Gang Sun
  • Xuying Tang
  • Shuihua Lu
  • Olivier Neyrolles
  • Qian Gao

Abstract

The mechanism of latent tuberculosis (TB) infection remains elusive. Several host factors that are involved in this complex process were previously identified. Micro RNAs (miRNAs) are endogenous ∼22 nt RNAs that play important regulatory roles in a wide range of biological processes. Several studies demonstrated the clinical usefulness of miRNAs as diagnostic or prognostic biomarkers in various malignancies and in a few nonmalignant diseases. To study the role of miRNAs in the transition from latent to active TB and to discover candidate biomarkers of this transition, we used human miRNA microarrays to probe the transcriptome of peripheral blood mononuclear cells (PBMCs) in patients with active TB, latent TB infection (LTBI), and healthy controls. Using the software package BRB Array Tools for data analyses, 17 miRNAs were differentially expressed between the three groups (P

Suggested Citation

  • Chuan Wang & Shunyao Yang & Gang Sun & Xuying Tang & Shuihua Lu & Olivier Neyrolles & Qian Gao, 2011. "Comparative miRNA Expression Profiles in Individuals with Latent and Active Tuberculosis," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0025832
    DOI: 10.1371/journal.pone.0025832
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    2. Jonathan B. Johnnidis & Marian H. Harris & Robert T. Wheeler & Sandra Stehling-Sun & Michael H. Lam & Oktay Kirak & Thijn R. Brummelkamp & Mark D. Fleming & Fernando D. Camargo, 2008. "Regulation of progenitor cell proliferation and granulocyte function by microRNA-223," Nature, Nature, vol. 451(7182), pages 1125-1129, February.
    3. Matthew P. R. Berry & Christine M. Graham & Finlay W. McNab & Zhaohui Xu & Susannah A. A. Bloch & Tolu Oni & Katalin A. Wilkinson & Romain Banchereau & Jason Skinner & Robert J. Wilkinson & Charles Qu, 2010. "An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis," Nature, Nature, vol. 466(7309), pages 973-977, August.
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