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An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

Author

Listed:
  • Matthew P. R. Berry

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Christine M. Graham

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Finlay W. McNab

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Zhaohui Xu

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Susannah A. A. Bloch

    (St. Mary’s Hospital, Imperial College Healthcare NHS Trust)

  • Tolu Oni

    (Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
    Wright Fleming Institute, Imperial College)

  • Katalin A. Wilkinson

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town)

  • Romain Banchereau

    (UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA)

  • Jason Skinner

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Robert J. Wilkinson

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
    Wright Fleming Institute, Imperial College)

  • Charles Quinn

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Derek Blankenship

    (Institute for Health Care Research and Improvement, Baylor Health Care System)

  • Ranju Dhawan

    (St Mary’s Hospital, Imperial College Healthcare NHS Trust)

  • John J. Cush

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Asuncion Mejias

    (Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, Ohio 43205, USA)

  • Octavio Ramilo

    (Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, Ohio 43205, USA)

  • Onn M. Kon

    (St. Mary’s Hospital, Imperial College Healthcare NHS Trust)

  • Virginia Pascual

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Jacques Banchereau

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Damien Chaussabel

    (Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA)

  • Anne O’Garra

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

Abstract

A tuberculosis biomarker The immune response to Mycobacterium tuberculosis is complex and incompletely characterized, hindering the development of new diagnostics, treatments and vaccines. A systems-biology approach has now been used to compare the transcriptional profiles of expressed genes in patients with active and latent tuberculosis and in healthy controls. Active pulmonary disease is shown to correlate with a neutrophil-driven interferon-inducible gene profile. About 10% of people with latent tuberculosis go on to develop the active disease. In this study, 10% of latent patients displayed a transcriptional signature similar to that in the active disease, suggesting that the biomarker may be useful in both prognosis and diagnosis.

Suggested Citation

  • Matthew P. R. Berry & Christine M. Graham & Finlay W. McNab & Zhaohui Xu & Susannah A. A. Bloch & Tolu Oni & Katalin A. Wilkinson & Romain Banchereau & Jason Skinner & Robert J. Wilkinson & Charles Qu, 2010. "An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis," Nature, Nature, vol. 466(7309), pages 973-977, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7309:d:10.1038_nature09247
    DOI: 10.1038/nature09247
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    Citations

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    Cited by:

    1. Bhaswati Pandit, 2017. "Genes and Genetics of Tuberculosis," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 1(4), pages 99-104, May.
    2. Humphrey Mulenga & Chambrez-Zita Zauchenberger & Erick W Bunyasi & Stanley Kimbung Mbandi & Simon C Mendelsohn & Benjamin Kagina & Adam Penn-Nicholson & Thomas J Scriba & Mark Hatherill, 2020. "Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-17, August.
    3. Nuno H Franco & Margarida Correia-Neves & I Anna S Olsson, 2012. "How “Humane” Is Your Endpoint?—Refining the Science-Driven Approach for Termination of Animal Studies of Chronic Infection," PLOS Pathogens, Public Library of Science, vol. 8(1), pages 1-4, January.
    4. Romain Banchereau & Alejandro Jordan-Villegas & Monica Ardura & Asuncion Mejias & Nicole Baldwin & Hui Xu & Elizabeth Saye & Jose Rossello-Urgell & Phuong Nguyen & Derek Blankenship & Clarence B Creec, 2012. "Host Immune Transcriptional Profiles Reflect the Variability in Clinical Disease Manifestations in Patients with Staphylococcus aureus Infections," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-11, April.
    5. Chuan Wang & Shunyao Yang & Gang Sun & Xuying Tang & Shuihua Lu & Olivier Neyrolles & Qian Gao, 2011. "Comparative miRNA Expression Profiles in Individuals with Latent and Active Tuberculosis," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-11, October.
    6. Bhaswati Pandit, 2017. "Genes and Genetics of Tuberculosis," International Journal of Pulmonary & Respiratory Sciences, Juniper Publishers Inc., vol. 1(4), pages 1-7, May.
    7. Wondwossen A Gebreyes & Jean Dupouy-Camet & Melanie J Newport & Celso J B Oliveira & Larry S Schlesinger & Yehia M Saif & Samuel Kariuki & Linda J Saif & William Saville & Thomas Wittum & Armando Hoet, 2014. "The Global One Health Paradigm: Challenges and Opportunities for Tackling Infectious Diseases at the Human, Animal, and Environment Interface in Low-Resource Settings," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 8(11), pages 1-6, November.

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