Vaccine innovation, translational research and the management of knowledge accumulation
AbstractWhat does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving processes that generate knowledge which is often fragmented and only locally valid. This paper details some of the conditions that allow fragmented, local knowledge to accumulate through a series of structured steps from the artificial simplicity of the laboratory to the complexity of real world application. Poliomyelitis is used as an illustrative case to highlight the importance of experimental animal models and the extent of co-ordination that can be required if they are missing. Implications for the governance and management of current attempts to produce vaccines for HIV, TB and Malaria are discussed.
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Bibliographic InfoArticle provided by Elsevier in its journal Social Science & Medicine.
Volume (Year): 75 (2012)
Issue (Month): 12 ()
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- Blume, Stuart, 2006. "Anti-vaccination movements and their interpretations," Social Science & Medicine, Elsevier, vol. 62(3), pages 628-642, February.
- Blume, Stuart & Tump, Janneke, 2010. "Evidence and policymaking: The introduction of MMR vaccine in the Netherlands," Social Science & Medicine, Elsevier, vol. 71(6), pages 1049-1055, September.
- Archibugi, Daniele & .Kim Bizzarri, 2004.
"Committing to Vaccine R&D: A Global Science Policy Priority/Comprometerse en la investigación y desarrollo de vacunas: una prioridad de la política científica global,"
Estudios de Economía Aplicada,
Estudios de Economía Aplicada, vol. 22, pages 251-271, Agosto.
- Archibugi, Daniele & Bizzarri, Kim, 2004. "Committing to vaccine R&D: a global science policy priority," Research Policy, Elsevier, vol. 33(10), pages 1657-1671, December.
- Bryder, Linda, 1999. "'We shall not find salvation in inoculation': BCG vaccination in Scandinavia, Britain and the USA, 1921-1960," Social Science & Medicine, Elsevier, vol. 49(9), pages 1157-1167, November.
- Nightingale, Paul, 2004. "Technological capabilities, invisible infrastructure and the un-social construction of predictability: the overlooked fixed costs of useful research," Research Policy, Elsevier, vol. 33(9), pages 1259-1284, November.
- Jean O. Lanjouw, 2003. "Intellectual Property and the Availability of Pharmaceuticals in Poor Countries," NBER Chapters, in: Innovation Policy and the Economy, Volume 3, pages 91-130 National Bureau of Economic Research, Inc.
- Poltorak, Mike & Leach, Melissa & Fairhead, James & Cassell, Jackie, 2005. "'MMR talk' and vaccination choices: An ethnographic study in Brighton," Social Science & Medicine, Elsevier, vol. 61(3), pages 709-719, August.
- Bastien, Joseph W., 1995. "Cross cultural communication of tetanus vaccinations in Bolivia," Social Science & Medicine, Elsevier, vol. 41(1), pages 77-86, July.
- Richard R. Nelson, 2008. "Factors affecting the power of technological paradigms," Industrial and Corporate Change, Oxford University Press, vol. 17(3), pages 485-497, June.
- Nelson, Richard R. & Buterbaugh, Kristin & Perl, Marcel & Gelijns, Annetine, 2011. "How medical know-how progresses," Research Policy, Elsevier, vol. 40(10), pages 1339-1344.
- Blume, Stuart & Zanders, Mariska, 2006. "Vaccine independence, local competences and globalisation: Lessons from the history of pertussis vaccines," Social Science & Medicine, Elsevier, vol. 63(7), pages 1825-1835, October.
- Mays, Rose M. & Sturm, Lynne A. & Zimet, Gregory D., 2004. "Parental perspectives on vaccinating children against sexually transmitted infections," Social Science & Medicine, Elsevier, vol. 58(7), pages 1405-1413, April.
- Dosi, Giovanni, 1982.
"Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change,"
Elsevier, vol. 11(3), pages 147-162, June.
- Dosi, Giovanni, 1993. "Technological paradigms and technological trajectories : A suggested interpretation of the determinants and directions of technical change," Research Policy, Elsevier, vol. 22(2), pages 102-103, April.
- Nichter, Mark, 1995. "Vaccinations in the third world: A consideration of community demand," Social Science & Medicine, Elsevier, vol. 41(5), pages 617-632, September.
- Blume, Stuart S., 2005. "Lock in, the state and vaccine development: Lessons from the history of the polio vaccines," Research Policy, Elsevier, vol. 34(2), pages 159-173, March.
- Bonu, Sekhar & Rani, Manju & Baker, Timothy D., 2003. "The impact of the national polio immunization campaign on levels and equity in immunization coverage: evidence from rural North India," Social Science & Medicine, Elsevier, vol. 57(10), pages 1807-1819, November.
- Yaqub, Ohid & Castle-Clarke, Sophie & Sevdalis, Nick & Chataway, Joanna, 2014. "Attitudes to vaccination: A critical review," Social Science & Medicine, Elsevier, vol. 112(C), pages 1-11.
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