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Economies of Scale in Experimentation: Knowledge and Technology in Pharmaceutical R&D

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Author Info
Nightingale, Paul

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Abstract

This paper explores how changes in genetics, database, high-throughput screening and bioinformatics technologies have allowed pharmaceutical firms to exploit economies of scale in experimentation. Traditional craft-based, sequential experimentation in chemistry and biology has been complemented by firstly, the automated, mass-production analysis of populations and secondly, by "in silico" experimentation using simulations and databases. The changes are analysed within a Chandlerian framework that highlights how increases in the "throughput" of R&D are dependent on organizational and managerial responses to systemic uncertainty. Copyright 2000 by Oxford University Press.

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Publisher Info
Article provided by Oxford University Press in its journal Industrial & Corporate Change.

Volume (Year): 9 (2000)
Issue (Month): 2 (June)
Pages: 315-59
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Handle: RePEc:oup:indcch:v:9:y:2000:i:2:p:315-59

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  1. Nicola Lacetera, 2003. "Incentives and spillovers in R&D activities: an agency-theoretic analysis of industry-university relations," Microeconomics 0312004, EconWPA. [Downloadable!]
  2. Criscuolo,Paola & Narula,Rajneesh, 2005. "Using multi-hub structures for international R&D: Organizational inertia and the challenges of implementation," Research Memoranda 025, Maastricht : MERIT, Maastricht Economic Research Institute on Innovation and Technology. [Downloadable!]
    Other versions:
  3. Sandro Mendonça, 2005. "The Revolution Within: ICT and the Shifting Knowledge Base of the World’s Largest Companies," LEM Papers Series 2005/19, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy. [Downloadable!]
    Other versions:
  4. Keith Pavitt, 2003. "The Process of Innovation," SPRU Electronic Working Paper Series 89, University of Sussex, SPRU - Science and Technology Policy Research. [Downloadable!]
  5. Christian Zeller, 2002. "Project Teams as Means of Restructuring Research and Development in the Pharmaceutical Industry," Regional Studies, Taylor and Francis Journals, vol. 36(3), pages 275-289, May. [Downloadable!] (restricted)
  6. Jacqueline Senker, 2006. "Biotechnology Alliances in the European Pharmaceutical Industry: Past, Present and Future," SPRU Electronic Working Paper Series 137, University of Sussex, SPRU - Science and Technology Policy Research. [Downloadable!]
  7. Finn Valentin & Henrich Dahlgren & Rasmus Lund Jensen, 2006. "Research Strategies in Science-based Start-ups - Effects on performance in Danish and Swedish biotechnology," DRUID Working Papers 06-11, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies. [Downloadable!]
  8. Emmanuel Duguet & Stéphanie Monjon, 2004. "Is innovation persistent at the firm Level . An econometric examination comparing the propensity score and regression methods," Cahiers de la Maison des Sciences Economiques v04075, Université Panthéon-Sorbonne (Paris 1). [Downloadable!]
  9. Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2003. "The Knowledge Bases of the World's Largest Pharmaceuticals Groups: what do Patent Citations to Non-Patent Literature Reveal?," SPRU Electronic Working Paper Series 90, University of Sussex, SPRU - Science and Technology Policy Research. [Downloadable!]
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