Economies of Scale in Experimentation: Knowledge and Technology in Pharmaceutical R&D
AbstractThis paper explores how changes in genetics, database, high-throughput screening and bioinformatics technologies have allowed pharmaceutical firms to exploit economies of scale in experimentation. Traditional craft-based, sequential experimentation in chemistry and biology has been complemented by firstly, the automated, mass-production analysis of populations and secondly, by "in silico" experimentation using simulations and databases. The changes are analysed within a Chandlerian framework that highlights how increases in the "throughput" of R&D are dependent on organizational and managerial responses to systemic uncertainty. Copyright 2000 by Oxford University Press.
Download InfoTo our knowledge, this item is not available for download. To find whether it is available, there are three options:
1. Check below under "Related research" whether another version of this item is available online.
2. Check on the provider's web page whether it is in fact available.
3. Perform a search for a similarly titled item that would be available.
Bibliographic InfoArticle provided by Oxford University Press in its journal Industrial & Corporate Change.
Volume (Year): 9 (2000)
Issue (Month): 2 (June)
Contact details of provider:
Postal: Oxford University Press, Great Clarendon Street, Oxford OX2 6DP, UK
Fax: 01865 267 985
Web page: http://icc.oupjournals.org/
You can help add them by filling out this form.
CitEc Project, subscribe to its RSS feed for this item.
- Criscuolo,Paola & Narula,Rajneesh, 2005.
"Using multi-hub structures for international R&D: Organizational inertia and the challenges of implementation,"
025, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT).
- Paola Criscuolo & Rajneesh Narula, 2005. "Using Multi-hub Structures for international R&D Organizational Inertia and the Challenges of Implementation," DRUID Working Papers 05-13, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies.
- Sandro Mendonça, 2005.
"The Revolution Within: ICT and the Shifting Knowledge Base of the World’s Largest Companies,"
LEM Papers Series
2005/19, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
- Sandro Mendonca, 2006. "The Revolution Within: Ict And The Shifting Knowledge Base Of The World'S Largest Companies," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 15(8), pages 777-799.
- Emmanuel Duguet & Stéphanie Monjon, 2004. "Is innovation persistent at the firm Level . An econometric examination comparing the propensity score and regression methods," Cahiers de la Maison des Sciences Economiques v04075, Université Panthéon-Sorbonne (Paris 1).
- Engwall, Mats & Freilich, Jonatan, 2014. "Architectural Lock-in of the Drug Development Process," INDEK Working Paper Series 2014/4, Department of Industrial Economics and Management, Royal Institute of Technology.
- Finn Valentin & Henrich Dahlgren & Rasmus Lund Jensen, 2006. "Research Strategies in Science-based Start-ups - Effects on performance in Danish and Swedish biotechnology," DRUID Working Papers 06-11, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies.
- Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2003.
"The Knowledge Bases of the World's Largest Pharmaceuticals Groups: what do Patent Citations to Non-Patent Literature Reveal?,"
SPRU Working Paper Series
90, SPRU - Science and Technology Policy Research, University of Sussex.
- Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2005. "The knowledge bases of the world's largest pharmaceutical groups: what do patent citations to non-patent literature reveal?," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 14(5), pages 395-415.
- Loasby, Brian J., 2002. "The evolution of knowledge: beyond the biological model," Research Policy, Elsevier, vol. 31(8-9), pages 1227-1239, December.
- Jörg Mahlich, 2010. "Patents and performance in the Japanese pharmaceutical industry: An institution-based view," Asia Pacific Journal of Management, Springer, vol. 27(1), pages 99-113, March.
- Jacqueline Senker, 2006. "Biotechnology Alliances in the European Pharmaceutical Industry: Past, Present and Future," SPRU Working Paper Series 137, SPRU - Science and Technology Policy Research, University of Sussex.
- Guerzoni, Marco & Aldridge, Taylor & Audretsch, David B & Sameeksha, Desai, 2012. "University Knowledge, Originality of Patents and the Creation of New Industries," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201219, University of Turin.
- Mahlich ,Jörg C. & Roediger-Schluga,Thomas, 2001. "The Changing Nature of Pharmaceutical R&D - Opportunities for Asia?," Research Memorandum 001, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT).
- Christian Zeller, 2002. "Project Teams as Means of Restructuring Research and Development in the Pharmaceutical Industry," Regional Studies, Taylor & Francis Journals, vol. 36(3), pages 275-289.
- Nicola Lacetera, 2003. "Incentives and spillovers in R&D activities: an agency-theoretic analysis of industry-university relations," Microeconomics 0312004, EconWPA.
- Yao-Sheng Liao, 2011. "The effect of human resource management control systems on the relationship between knowledge management strategy and firm performance," International Journal of Manpower, Emerald Group Publishing, vol. 32(5/6), pages 494-511, September.
- Keith Pavitt, 2003. "The Process of Innovation," SPRU Working Paper Series 89, SPRU - Science and Technology Policy Research, University of Sussex.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Oxford University Press) or (Christopher F. Baum).
If references are entirely missing, you can add them using this form.