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Economies of Scale in Experimentation: Knowledge and Technology in Pharmaceutical R&D

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  • Nightingale, Paul

Abstract

This paper explores how changes in genetics, database, high-throughput screening and bioinformatics technologies have allowed pharmaceutical firms to exploit economies of scale in experimentation. Traditional craft-based, sequential experimentation in chemistry and biology has been complemented by firstly, the automated, mass-production analysis of populations and secondly, by "in silico" experimentation using simulations and databases. The changes are analysed within a Chandlerian framework that highlights how increases in the "throughput" of R&D are dependent on organizational and managerial responses to systemic uncertainty. Copyright 2000 by Oxford University Press.

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Bibliographic Info

Article provided by Oxford University Press in its journal Industrial & Corporate Change.

Volume (Year): 9 (2000)
Issue (Month): 2 (June)
Pages: 315-59

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Handle: RePEc:oup:indcch:v:9:y:2000:i:2:p:315-59

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Cited by:
  1. Jacqueline Senker, 2006. "Biotechnology Alliances in the European Pharmaceutical Industry: Past, Present and Future," SPRU Working Paper Series, SPRU - Science and Technology Policy Research, University of Sussex 137, SPRU - Science and Technology Policy Research, University of Sussex.
  2. Loasby, Brian J., 2002. "The evolution of knowledge: beyond the biological model," Research Policy, Elsevier, Elsevier, vol. 31(8-9), pages 1227-1239, December.
  3. Mahlich ,Jörg C. & Roediger-Schluga,Thomas, 2001. "The Changing Nature of Pharmaceutical R&D - Opportunities for Asia?," Research Memorandum, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT) 001, Maastricht University, Maastricht Economic Research Institute on Innovation and Technology (MERIT).
  4. Yao-Sheng Liao, 2011. "The effect of human resource management control systems on the relationship between knowledge management strategy and firm performance," International Journal of Manpower, Emerald Group Publishing, Emerald Group Publishing, vol. 32(5/6), pages 494-511, September.
  5. Jörg Mahlich, 2010. "Patents and performance in the Japanese pharmaceutical industry: An institution-based view," Asia Pacific Journal of Management, Springer, Springer, vol. 27(1), pages 99-113, March.
  6. Emmanuel Duguet & Stéphanie Monjon, 2004. "Is innovation persistent at the firm Level . An econometric examination comparing the propensity score and regression methods," Cahiers de la Maison des Sciences Economiques, Université Panthéon-Sorbonne (Paris 1) v04075, Université Panthéon-Sorbonne (Paris 1).
  7. Finn Valentin & Henrich Dahlgren & Rasmus Lund Jensen, 2006. "Research Strategies in Science-based Start-ups - Effects on performance in Danish and Swedish biotechnology," DRUID Working Papers, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies 06-11, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies.
  8. Stefano Brusoni & Paola Criscuolo & Aldo Geuna, 2003. "The Knowledge Bases of the World's Largest Pharmaceuticals Groups: what do Patent Citations to Non-Patent Literature Reveal?," SPRU Working Paper Series, SPRU - Science and Technology Policy Research, University of Sussex 90, SPRU - Science and Technology Policy Research, University of Sussex.
  9. Engwall, Mats & Freilich, Jonatan, 2014. "Architectural Lock-in of the Drug Development Process," INDEK Working Paper Series, Department of Industrial Economics and Management, Royal Institute of Technology 2014/4, Department of Industrial Economics and Management, Royal Institute of Technology.
  10. Paola Criscuolo & Rajneesh Narula, 2005. "Using Multi-hub Structures for international R&D Organizational Inertia and the Challenges of Implementation," DRUID Working Papers, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies 05-13, DRUID, Copenhagen Business School, Department of Industrial Economics and Strategy/Aalborg University, Department of Business Studies.
  11. Sandro Mendonça, 2005. "The Revolution Within: ICT and the Shifting Knowledge Base of the World’s Largest Companies," LEM Papers Series, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy 2005/19, Laboratory of Economics and Management (LEM), Sant'Anna School of Advanced Studies, Pisa, Italy.
  12. Guerzoni, Marco & Aldridge, Taylor & Audretsch, David B & Sameeksha, Desai, 2012. "University Knowledge, Originality of Patents and the Creation of New Industries," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 201219, University of Turin.
  13. Christian Zeller, 2002. "Project Teams as Means of Restructuring Research and Development in the Pharmaceutical Industry," Regional Studies, Taylor & Francis Journals, Taylor & Francis Journals, vol. 36(3), pages 275-289.
  14. Nicola Lacetera, 2003. "Incentives and spillovers in R&D activities: an agency-theoretic analysis of industry-university relations," Microeconomics, EconWPA 0312004, EconWPA.
  15. Keith Pavitt, 2003. "The Process of Innovation," SPRU Working Paper Series, SPRU - Science and Technology Policy Research, University of Sussex 89, SPRU - Science and Technology Policy Research, University of Sussex.

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