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Content
January 2026, Volume 649, Issue 8095
- 194-204 Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells
by Jyh Liang Hor & Edward C. Schrom & Abigail Wong-Rolle & Luke Vistain & Wanjing Shang & Qiang Dong & Chen Zhao & Chengcheng Jin & Ronald N. Germain - 205-215 NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
by Jinho Jeong & Simone Hausmann & Hanyang Dong & Kacper Szczepski & Natasha M. Flores & Andy Garcia Gonzalez & Liyang Shi & Xiaoyin Lu & Joanna Lempiäinen & Moritz Jakab & Liyong Zeng & Tourkian Chasan & Eric Bareke & Rui Dong & Emma Carlson & Reinnier Padilla & Dylan Husmann & Julia Thompson & Gerry A. Shipman & Emily Zahn & Courtney A. Barnes & Laiba F. Khan & Liz Marie Albertorio-Sáez & Eva Brill & Vishnu Udayakumar Sunita Kumary & Matthew R. Marunde & Danielle N. Maryanski & Cheryl C. Szany & Bryan J. Venters & Carolina Lin Windham & Michal Eligiusz Nowakowski & Iwona Czaban & Mariusz Jaremko & Michael-Christopher Keogh & Kang Le & Michael J. Soth & Benjamin A. Garcia & Łukasz Jaremko & Jacek Majewski & Pawel K. Mazur & Or Gozani - 216-226 NSD2 targeting reverses plasticity and drug resistance in prostate cancer
by Jia J. Li & Alessandro Vasciaveo & Dimitris Karagiannis & Zhen Sun & Kristjan H. Gretarsson & Xiao Chen & Ouathek Ouerfelli & Fabio Socciarelli & Ziv Frankenstein & Hanyang Dong & Min Zou & Wei Yuan & Guangli Yang & Gabriel M. Aizenman & Tania Pannellini & Xinjing Xu & Himisha Beltran & Yu Chen & Kevin Gardner & Brian D. Robinson & Johann de Bono & Or Gozani & Cory Abate-Shen & Mark A. Rubin & Massimo Loda & Charles L. Sawyers & Andrea Califano & Chao Lu & Michael M. Shen - 227-236 Secretome translation shaped by lysosomes and lunapark-marked ER junctions
by Heejun Choi & Ya-Cheng Liao & Young J. Yoon & Jonathan Grimm & Nan Wang & Luke D. Lavis & Robert H. Singer & Jennifer Lippincott-Schwartz - 237-245 Computational enzyme design by catalytic motif scaffolding
by Markus Braun & Adrian Tripp & Morakot Chakatok & Sigrid Kaltenbrunner & Celina Fischer & David Stoll & Aleksandar Bijelic & Wael Elaily & Massimo G. Totaro & Melanie Moser & Shlomo Y. Hoch & Horst Lechner & Federico Rossi & Matteo Aleotti & Mélanie Hall & Gustav Oberdorfer - 246-253 Computational design of metallohydrolases
by Donghyo Kim & Seth M. Woodbury & Woody Ahern & Doug Tischer & Alex Kang & Emily Joyce & Asim K. Bera & Nikita Hanikel & Saman Salike & Rohith Krishna & Jason Yim & Samuel J. Pellock & Anna Lauko & Indrek Kalvet & Donald Hilvert & David Baker - 255-257 Nine books to help shape your science career in 2026
by Anne Gulland - 260-260 Probing pollutants: how I use penguin faeces to measure contaminants in Antarctica
by Rachael Pells
December 2025, Volume 648, Issue 8094
- 12-13 Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
by Nobutaka Kato & Eamon Comer & Tomoyo Sakata-Kato & Arvind Sharma & Manmohan Sharma & Micah Maetani & Jessica Bastien & Nicolas M. Brancucci & Joshua A. Bittker & Victoria Corey & David Clarke & Emily R. Derbyshire & Gillian L. Dornan & Sandra Duffy & Sean Eckley & Maurice A. Itoe & Karin M. J. Koolen & Timothy A. Lewis & Ping S. Lui & Amanda K. Lukens & Emily Lund & Sandra March & Elamaran Meibalan & Bennett C. Meier & Jacob A. McPhail & Branko Mitasev & Eli L. Moss & Morgane Sayes & Yvonne Van Gessel & Mathias J. Wawer & Takashi Yoshinaga & Anne-Marie Zeeman & Vicky M. Avery & Sangeeta N. Bhatia & John E. Burke & Flaminia Catteruccia & Jon C. Clardy & Paul A. Clemons & Koen J. Dechering & Jeremy R. Duvall & Michael A. Foley & Fabian Gusovsky & Clemens H. M. Kocken & Matthias Marti & Marshall L. Morningstar & Benito Munoz & Daniel E. Neafsey & Amit Sharma & Elizabeth A. Winzeler & Dyann F. Wirth & Christina A. Scherer & Stuart L. Schreiber - 14-14 Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale
by Denis Firsanov & Max Zacher & Xiao Tian & Todd L. Sformo & Yang Zhao & Gregory Tombline & J. Yuyang Lu & Zhizhong Zheng & Luigi Perelli & Enrico Gurreri & Li Zhang & Jing Guo & Anatoly Korotkov & Valentin Volobaev & Seyed Ali Biashad & Zhihui Zhang & Johanna Heid & Alexander Y. Maslov & Shixiang Sun & Zhuoer Wu & Jonathan Gigas & Eric C. Hillpot & John C. Martinez & Minseon Lee & Alyssa Williams & Abbey Gilman & Nicholas Hamilton & Ekaterina Strelkova & Ena Haseljic & Avnee Patel & Maggie E. Straight & Nalani Miller & Julia Ablaeva & Lok Ming Tam & Chloé Couderc & Michael R. Hoopmann & Robert L. Moritz & Shingo Fujii & Amandine Pelletier & Dan J. Hayman & Hongrui Liu & Yuxuan Cai & Anthony K. L. Leung & Zhengdong Zhang & C. Bradley Nelson & Lisa M. Abegglen & Joshua D. Schiffman & Vadim N. Gladyshev & Carlo C. Maley & Mauro Modesti & Giannicola Genovese & Mirre J. P. Simons & Jan Vijg & Andrei Seluanov & Vera Gorbunova - 15-15 Author Correction: The first-principles phase diagram of monolayer nanoconfined water
by Venkat Kapil & Christoph Schran & Andrea Zen & Ji Chen & Chris J. Pickard & Angelos Michaelides - 16-16 Author Correction: Video‐rate tunable colour electronic paper with human resolution
by Ade Satria Saloka Santosa & Yu-Wei Chang & Andreas B. Dahlin & Lars Österlund & Giovanni Volpe & Kunli Xiong - 17-17 Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
by Kim Newton & Katherine E. Wickliffe & Debra L. Dugger & Allie Maltzman & Merone Roose-Girma & Monika Dohse & László Kőműves & Joshua D. Webster & Vishva M. Dixit - 18-18 Author Correction: Seismic detection of a 600-km solid inner core in Mars
by Huixing Bi & Daoyuan Sun & Ningyu Sun & Zhu Mao & Mingwei Dai & Douglas Hemingway - 19-19 Editorial Expression of Concern: Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
by Takeshi Fujiwara & Madhavi Bandi & Masayuki Nitta & Elena V. Ivanova & Roderick T. Bronson & David Pellman - 500-500 How my institution strengthened research despite chronic underfunding
by Anil Shanker - 508-513 The best science images of 2025 — Nature’s picks
by Emma Stoye & Fred Schwaller - 516-517 The top US health director who stood up for science — and was fired
by Max Kozlov - 518-518 This science sleuth revealed a retraction crisis at Indian universities
by Miryam Naddaf - 519-519 The visionary physicist who gave us a new way to view the cosmos
by Davide Castelvecchi - 520-521 The first global pandemic treaty — and the woman who made it happen
by Celeste Biever - 522-522 ‘Giant step forward’ for Huntington’s — the scientist behind the first gene therapy
by Elie Dolgin - 523-523 9,000 metres under the sea: this researcher found the deepest animal ecosystems on Earth
by Rachel Fieldhouse - 524-525 This scientist is breeding billions of mosquitoes to fight disease in Brazil
by Mariana Lenharo - 526-526 The Chinese finance whizz whose DeepSeek AI model stunned the world
by Elizabeth Gibney - 527-527 This scientist found a new trick of the immune system by digging through cellular rubbish
by Cassandra Willyard - 528-529 The baby whose life was saved by the first personalized CRISPR therapy
by Heidi Ledford - 530-531 Grant cuts, arrests, lay-offs: Trump made 2025 a tumultuous year for science
by Jeff Tollefson - 532-534 In praise of inefficiency, failure and friendship: ten galvanizing reads for this festive season
by Kelly-Ann Allen & Tara McAllister & Yamini Aiyar & Sirry Alang & Misa Shimuta & Elma Kay & Mohamed Ibrahim & Mariana Viglino & Séverine Toussaert & Nick Lane - 535-537 AI is transforming the economy — understanding its impact requires both data and imagination
by Daniel Björkegren - 543-544 Weighing up the wild-meat harvest in Amazonia
by Carla Morsello & Patricia Carignano Torres - 544-546 Solar cells that combine multiple perovskite layers surpass 30% efficiency
by Shuaifeng Hu & Henry J. Snaith - 546-548 Mystery owner of African hominin foot identified
by Fred Spoor - 548-549 Ancient DNA offers clues about mysterious prehistoric settlement in China
by Yu Dong & Ripan S. Malhi - 551-555 Experiments reveal extreme water generation during planet formation
by F. Miozzi & A. Shahar & E. D. Young & J. Wang & A. Steele & S. Borensztajn & S. M. Vitale & E. S. Bullock & N. Wehr & J. Badro - 556-561 Titan’s strong tidal dissipation precludes a subsurface ocean
by Flavio Petricca & Steven D. Vance & Marzia Parisi & Dustin Buccino & Gael Cascioli & Julie Castillo-Rogez & Brynna G. Downey & Francis Nimmo & Gabriel Tobie & Baptiste Journaux & Andrea Magnanini & Ula Jones & Mark Panning & Amirhossein Bagheri & Antonio Genova & Jonathan I. Lunine - 562-568 Laser spectroscopy and CP-violation sensitivity of actinium monofluoride
by M. Athanasakis-Kaklamanakis & M. Au & A. Kyuberis & C. Zülch & K. Gaul & H. Wibowo & L. Skripnikov & L. Lalanne & J. R. Reilly & Á. Koszorús & S. Bara & J. Ballof & R. Berger & C. Bernerd & A. Borschevsky & A. A. Breier & K. Chrysalidis & T. E. Cocolios & R. P. de Groote & A. Dorne & J. Dobaczewski & C. M. Fajardo Zambrano & K. T. Flanagan & S. Franchoo & J. D. Johnson & R. F. Garcia Ruiz & D. Hanstorp & S. Kujanpää & Y. C. Liu & K. M. Lynch & A. McGlone & N. S. Mosyagin & G. Neyens & M. Nichols & L. Nies & F. Pastrana & S. Rothe & W. Ryssens & B. van den Borne & J. Wessolek & S. G. Wilkins & X. F. Yang - 569-575 An 11-qubit atom processor in silicon
by Hermann Edlbauer & Junliang Wang & A. M. Saffat-Ee Huq & Ian Thorvaldson & Michael T. Jones & Saiful Haque Misha & William J. Pappas & Christian M. Moehle & Yu-Ling Hsueh & Henric Bornemann & Samuel K. Gorman & Yousun Chung & Joris G. Keizer & Ludwik Kranz & Michelle Y. Simmons - 576-584 Programmable 200 GOPS Hopfield-inspired photonic Ising machine
by Nayem Al-Kayed & Charles St-Arnault & Hugh Morison & A. Aadhi & Chaoran Huang & Alexander N. Tait & David V. Plant & Bhavin J. Shastri - 585-590 Visualizing interaction-driven restructuring of quantum Hall edge states
by Jiachen Yu & Haotan Han & Kristina G. Wolinski & Ruihua Fan & Amir S. Mohammadi & Tianle Wang & Taige Wang & Liam Cohen & Kenji Watanabe & Takashi Taniguchi & Andrea F. Young & Michael P. Zaletel & Ali Yazdani - 591-599 3D nanolithography with metalens arrays and spatially adaptive illumination
by Songyun Gu & Chenkai Mao & Anna Guell Izard & Sarvesh Sadana & Dongping Terrel-Perez & Magi Mettry-Yassa & Wonjin Choi & Wenjie Zhou & Hujie Yan & Ziran Zhou & Travis Massey & Alex Abelson & You Zhou & Sijia Huang & Chiara Daraio & Thejaswi Umanath Tumkur & Jonathan A. Fan & Xiaoxing Xia - 600-606 All-perovskite tandem solar cells with dipolar passivation
by Renxing Lin & Han Gao & Jing Lou & Jian Xu & Mengran Yin & Pu Wu & Chenshuaiyu Liu & Yijia Guo & Enzuo Wang & Shuncheng Yang & Runnan Liu & Dong Zhou & Changzeng Ding & Anh Dinh Bui & Ni Yin & Daniel H. Macdonald & Chang-Qi Ma & Qi Chen & Ke Xiao & Xin Luo & Ye Liu & Ludong Li & Yongxi Li & Chao Chang & Hairen Tan - 607-615 Selective methylene oxidation in α,β-unsaturated carbonyl natural products
by Chiyoung Ahn & Alexander Gomez & Marc A. Hartmann & M. Christina White - 616-624 The global hydrogen budget
by Zutao Ouyang & Robert B. Jackson & Marielle Saunois & Josep G. Canadell & Yuanhong Zhao & Catherine Morfopoulos & Paul B. Krummel & Prabir K. Patra & Glen P. Peters & Fraser Dennison & Thomas Gasser & Alexander T. Archibald & Vivek Arora & Gabriel Baudoin & Naveen Chandra & Philippe Ciais & Steven J. Davis & Sarah Feron & Fangzhou Guo & Didier Hauglustaine & Christopher D. Jones & Matthew W. Jones & Etsushi Kato & Daniel Kennedy & Jürgen Knauer & Sebastian Lienert & Danica Lombardozzi & Joe R. Melton & Julia E.M.S. Nabel & Michael O’Sullivan & Gabrielle Pétron & Benjamin Poulter & Joeri Rogelj & David Sandoval Calle & Pete Smith & Parvadha Suntharalingam & Hanqin Tian & Chenghao Wang & Andy Wiltshire - 625-633 Healthy forests safeguard traditional wild meat food systems in Amazonia
by André Pinassi Antunes & Pedro de Araujo Lima Constantino & Julia E. Fa & Daniel P. Munari & Thais Q. Morcatty & Michelle C. M. Jacob & Bruce W. Nelson & Mariana Franco Cassino & Elildo A. R. Carvalho & Amy Ickowitz & Lauren Coad & Richard E. Bodmer & Pedro Mayor & Cecile Richard-Hansen & João Valsecchi & João V. Campos-Silva & Juarez C. B. Pezzuti & Miguel Aparício & Eduardo M. von Muhlen & Marcela Alvares Oliveira & Milton J. de Paula & Natalia C. Pimenta & Marina A. R. de Mattos Vieira & Marcelo A. Santos Junior & André V. Nunes & Jean P. Boubli & Luan M. G. Suruí & Eneias C. S. Paumari & Abimael V. C. Paumari & José Lino V. S. Paumari & Germano C. Paumari & Ana Paula L. R. Katukina & Dzoodzo Baniwa & Valencio S. M. Baniwa & Walter S. L. Baniwa & Abel O. F. Baniwa & Armindo B. Baniwa & Isaías J. S. Baniwa & Yaukuma Waura & Jairo Silvestre Apurinã & Valdir S. S. Apurinã & Josiane O. G. Tikuna & Elias P. A. L. Tikuna & José L. Kaxinauá & Kussugi B. Kuikuro & Jorge T. Penaforth Kaixana & George H. Rebelo & Dione Torquato & Vanessa S. F. Apurinã & Miguel Antúnez & Pedro E. Perez-Peña & Tula G. Fang & Pablo E. Puertas & Rolando M. Aquino & Louise Maranhão & Guillaume Longin & Cíntia K. M. Lopes & Hani R. El Bizri - 634-639 A long-necked early dinosaur from a newly discovered Upper Triassic basin in the Andes
by E. Martín Hechenleitner & Agustín G. Martinelli & Sebastián Rocher & Lucas E. Fiorelli & Malena Juarez & Jeremías R. A. Taborda & Julia B. Desojo - 640-648 New finds shed light on diet and locomotion in Australopithecus deyiremeda
by Yohannes Haile-Selassie & Gary T. Schwartz & Thomas C. Prang & Beverly Z. Saylor & Alan Deino & Luis Gibert & Anna Ragni & Naomi E. Levin - 649-658 From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes
by Victor Loegler & Pia Thiele & Elie Teyssonnière & Andreas Tsouris & Gauthier Brach & Corinne Cruaud & Emilie Payen & Stefan Engelen & Maitreya J. Dunham & Jing Hou & Anne Friedrich & Joseph Schacherer - 659-667 Ancient DNA from Shimao city records kinship practices in Neolithic China
by Zehui Chen & Jacob D. Gardner & Zhouyong Sun & E. Andrew Bennett & Qian Han & Xuesong Pei & Jing Shao & Han Shi & Wenjun Wang & Jiayang Xue & Fan Bai & Xiangming Dai & Nu He & Xiaoning Guo & Nan Di & Xiaowei Mao & Tianxiang Liu & Peng Cao & Feng Liu & Qingyan Dai & Xiaotian Feng & Wanjing Ping & Xiaohong Wu & Lizhao Zhang & Liang Chen & Qiaomei Fu - 668-677 Sensory expectations shape neural population dynamics in motor circuits
by Jonathan A. Michaels & Mehrdad Kashefi & Jack Zheng & Olivier Codol & Jeffrey Weiler & Rhonda Kersten & Jonathan C. Lau & Paul L. Gribble & Jörn Diedrichsen & J. Andrew Pruszynski - 678-685 A probabilistic histological atlas of the human brain for MRI segmentation
by Adrià Casamitjana & Matteo Mancini & Eleanor Robinson & Loïc Peter & Roberto Annunziata & Juri Althonayan & Shauna Crampsie & Emily Blackburn & Benjamin Billot & Alessia Atzeni & Oula Puonti & Yaël Balbastre & Peter Schmidt & James Hughes & Jean C. Augustinack & Brian L. Edlow & Lilla Zöllei & David L. Thomas & Dorit Kliemann & Martina Bocchetta & Catherine Strand & Janice L. Holton & Zane Jaunmuktane & Juan Eugenio Iglesias - 686-695 Florigen activation complex forms via multifaceted assembly in Arabidopsis
by He Gao & Na Ding & Yuang Wu & Dongli Yu & Shi-Zhao Zhou & Sara Christina Stolze & Coral Vincent & Gabriel Rodríguez Maroto & Pedro de los Reyes & Anne Harzen & Martina Cerise & Vítor da Silveira Falavigna & Ertong Li & Ton Timmers & Ulla Neumann & Hirofumi Nakagami & Jin-Yong Hu & Jijie Chai & George Coupland - 696-706 Multi-omic profiling reveals age-related immune dynamics in healthy adults
by Qiuyu Gong & Mehul Sharma & Marla C. Glass & Emma L. Kuan & Aishwarya Chander & Mansi Singh & Lucas T. Graybuck & Zachary J. Thomson & Christian M. LaFrance & Samir Rachid Zaim & Tao Peng & Lauren Y. Okada & Palak C. Genge & Katherine E. Henderson & Elisabeth M. Dornisch & Erik D. Layton & Peter J. Wittig & Alexander T. Heubeck & Nelson M. Mukuka & Julian Reading & Garrett Strawn & Teminijesu Titus-Adewunmi & Kathleen Abadie & Charles R. Roll & Veronica Hernandez & Vaishnavi Parthasarathy & Tyanna J. Stuckey & Blessing Musgrove & Elliott Swanson & Cara Lord & Morgan D. A. Weiss & Cole G. Phalen & Regina R. Mettey & Kevin J. Lee & John B. Johanneson & Erin K. Kawelo & Jessica Garber & Upaasana Krishnan & Megan Smithmyer & E. John Wherry & Laura A. Vella & Sarah E. Henrickson & Mackenzie S. Kopp & Adam K. Savage & Lynne A. Becker & Paul Meijer & Ernest M. Coffey & Jorg J. Goronzy & Mikael Sigvardsson & Cate Speake & Thomas F. Bumol & Ananda W. Goldrath & Troy R. Torgerson & Xiao-jun Li & Peter J. Skene & Jane H. Buckner & Claire E. Gustafson - 707-716 Host cell Z-RNAs activate ZBP1 during virus infections
by Chaoran Yin & Aleksandr Fedorov & Hongyan Guo & Jeremy Chase Crawford & Claire Rousseau & Xiao Zhong & Riley M. Williams & Avishekh Gautam & Heather S. Koehler & Adam W. Whisnant & Thomas Hennig & Anna Rozina & Yuhan Zhong & Shuangjuan Lv & Valter Bergant & Shuqi Wang & Peter Dröge & Sven Miller & Maria Poptsova & Jan Rehwinkel & Andreas Pichlmair & Edward S. Mocarski & Paul G. Thomas & Lars Dölken & Ting Zhang & Alan Herbert & Siddharth Balachandran - 717-725 Evidence for improved DNA repair in the long-lived bowhead whale
by Denis Firsanov & Max Zacher & Xiao Tian & Todd L. Sformo & Yang Zhao & Gregory Tombline & J. Yuyang Lu & Zhizhong Zheng & Luigi Perelli & Enrico Gurreri & Li Zhang & Jing Guo & Anatoly Korotkov & Valentin Volobaev & Seyed Ali Biashad & Zhihui Zhang & Johanna Heid & Alexander Y. Maslov & Shixiang Sun & Zhuoer Wu & Jonathan Gigas & Eric C. Hillpot & John C. Martinez & Minseon Lee & Alyssa Williams & Abbey Gilman & Nicholas Hamilton & Ekaterina Strelkova & Ena Haseljic & Avnee Patel & Maggie E. Straight & Nalani Miller & Julia Ablaeva & Lok Ming Tam & Chloé Couderc & Michael R. Hoopmann & Robert L. Moritz & Shingo Fujii & Amandine Pelletier & Dan J. Hayman & Hongrui Liu & Yuxuan Cai & Anthony K. L. Leung & Zhengdong Zhang & C. Bradley Nelson & Lisa M. Abegglen & Joshua D. Schiffman & Vadim N. Gladyshev & Carlo C. Maley & Mauro Modesti & Giannicola Genovese & Mirre J. P. Simons & Jan Vijg & Andrei Seluanov & Vera Gorbunova - 726-735 Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers
by Pedro B. Tan & Yara L. Verschoor & José G. van den Berg & Sara Balduzzi & Niels F. M. Kok & Marieke E. Ijsselsteijn & Kat Moore & Adham Jurdi & Antony Tin & Paulien Kaptein & Monique E. van Leerdam & John B. A. G. Haanen & Emile E. Voest & Noel F. C. C. de Miranda & Ton N. Schumacher & Lodewyk F. A. Wessels & Myriam Chalabi - 736-745 Anti-progestin therapy targets hallmarks of breast cancer risk
by Bruno M. Simões & Robert Pedley & Curtis W. McCloskey & Matthew Roberts & Austin D. Reed & Alecia-Jane Twigger & Pirashaanthy Tharmapalan & Amanda Caruso & Sara Cabral & Anthony J. Wilby & Hannah Harrison & Yuxi Zhou & Alice Greenhalgh & Suad A. Alghamdi & Martina Forestiero & Jesica Lopez-Muñoz & Jasmin Roche & Ren Jie Tuieng & Muhammad A. Khan & Steven Squires & Susan M. Astley & Elaine F. Harkness & Angélica Santiago-Gómez & Katherine Spence & Jessica Ritchie & Susan Pritchard & Yit Lim & Michael J. Sherratt & Sebastiano Andò & Anthony Howell & D. Gareth Evans & Andrew P. Gilmore & Walid T. Khaled & Rama Khokha & Robert B. Clarke & Sacha J. Howell - 746-754 Helicase-mediated mechanism of SSU processome maturation and disassembly
by Olga Buzovetsky & Sebastian Klinge - 755-763 Structural snapshots capture nucleotide release at the μ-opioid receptor
by Saif Khan & Aaliyah S. Tyson & Mohsen Ranjbar & Zixin Zhang & Jaskaran Singh & Gye Won Han & Cornelius Gati - 764-764 Retraction Note: The economic commitment of climate change
by Maximilian Kotz & Anders Levermann & Leonie Wenz - 765-767 Waste not: how researchers harness pee and poo for science
by Hannah Docter-Loeb - 770-770 Giving a voice to animals: Laos’s national herpetologist on her day-to-day
by Dave Tacon
December 2025, Volume 648, Issue 8093
- 5-5 Author Correction: A pangenome and pantranscriptome of hexaploid oat
by Raz Avni & Nadia Kamal & Lidija Bitz & Eric N. Jellen & Wubishet A. Bekele & Tefera T. Angessa & Petri Auvinen & Oliver Bitz & Brian Boyle & Francisco J. Canales & Craig H. Carlson & Brett Chapman & Harmeet Singh Chawla & Yutang Chen & Dario Copetti & Samara Correia de Lemos & Viet Dang & Steven R. Eichten & Kathy Esvelt Klos & Amit M. Fenn & Anne Fiebig & Yong-Bi Fu & Heidrun Gundlach & Rajeev Gupta & Georg Haberer & Tianhua He & Matthias H. Herrmann & Axel Himmelbach & Catherine J. Howarth & Haifei Hu & Julio Isidro y Sánchez & Asuka Itaya & Jean-Luc Jannink & Yong Jia & Rajvinder Kaur & Manuela Knauft & Tim Langdon & Thomas Lux & Sofia Marmon & Vanda Marosi & Klaus F. X. Mayer & Steve Michel & Raja Sekhar Nandety & Kirby T. Nilsen & Edyta Paczos-Grzęda & Asher Pasha & Elena Prats & Nicholas J. Provart & Adriana Ravagnani & Robert W. Reid & Jessica A. Schlueter & Alan H. Schulman & Taner Z. Sen & Jaswinder Singh & Mehtab Singh & Nick Sirijovski & Nils Stein & Bruno Studer & Sirja Viitala & Shauna Vronces & Sean Walkowiak & Penghao Wang & Amanda J. Waters & Charlene P. Wight & Weikai Yan & Eric Yao & Xiao-Qi Zhang & Gaofeng Zhou & Zhou Zhou & Nicholas A. Tinker & Jason D. Fiedler & Chengdao Li & Peter J. Maughan & Manuel Spannagl & Martin Mascher - 6-6 Author Correction: An asymmetric fission island driven by shell effects in light fragments
by P. Morfouace & J. Taieb & A. Chatillon & L. Audouin & G. Blanchon & R. N. Bernard & N. Dubray & N. Pillet & D. Regnier & H. Alvarez-Pol & F. Amjad & P. André & G. Authelet & L. Atar & T. Aumann & J. Benlliure & K. Boretzky & L. Bott & T. Brecelj & C. Caesar & P. Carpentier & E. Casarejos & J. Cederkäll & A. Corsi & D. Cortina-Gil & A. Cvetinović & E. De Filippo & T. Dickel & M. Feijoo & L. M. Fonseca & D. Galaviz & G. García-Jiménez & I. Gasparic & E. I. Geraci & R. Gernhäuser & B. Gnoffo & K. Göbel & A. Graña-González & E. Haettner & A.-L. Hartig & M. Heil & A. Heinz & T. Hensel & M. Holl & C. Hornung & A. Horvat & A. Jedele & D. Jelavic Malenica & T. Jenegger & L. Ji & H. T. Johansson & B. Jonson & B. Jurado & N. Kalantar-Nayestanaki & E. Kazantseva & A. Kelic-Heil & O. A. Kiselev & P. Klenze & R. Knöbel & D. Körper & D. Kostyleva & T. Kröll & N. Kuzminchuk & B. Laurent & I. Lihtar & Yu. A. Litvinov & B. Löher & N. S. Martorana & B. Mauss & S. Murillo Morales & D. Mücher & I. Mukha & E. Nacher & A. Obertelli & E. V. Pagano & V. Panin & J. Park & S. Paschalis & M. Petri & S. Pietri & S. Pirrone & G. Politi & L. Ponnath & A. Revel & H.-B. Rhee & J. L. Rodríguez-Sánchez & L. Rose & D. Rossi & P. Roy & P. Russotto & C. Scheidenberger & H. Scheit & H. Simon & S. Storck-Dutine & A. Stott & Y. L. Sun & C. Sürder & Y. K. Tanaka & R. Taniuchi & O. Tengblad & I. Tisma & H. T. Törnqvist & M. Trimarchi & S. Velardita & J. Vesic & B. Voss & F. Wamers & H. Weick & F. Wienholtz & J. Zhao & M. Zhukov - 7-7 Author Correction: Spatial fibroblast niches define Crohn’s fistulae
by Colleen McGregor & Xiao Qin & Marta Jagielowicz & Tarun Gupta & Zinan Yin & Verena Lentsch & David Fawkner-Corbett & Vy Wien Lai & Paula Gomez Castro & Esther Bridges & Chloe Hyun-Jung Lee & Huei-Wen Chuang & Lei Deng & Anna Aulicino & Renuka Teague & Sorayya Moradi & Jun Sung Park & Jeongmin Woo & Kexin Xu & Ruchi Tandon & Nicole Cianci & Jan Bornschein & Ling-Pei Ho & Paulina Siejka-Zielinska & Zoe Christoforidou & Sarah Hill & Johannes Lehmann & Rhea Kujawa & Paola Vargas Gutierrez & Carol Cheng & Maria Greco & Katherine Baker & Mark Bignell & Bruce George & Eve Fryer & Michael Vieth & Agne Antanaviciute & Alison Simmons - 8-8 Author Correction: Photocatalytic low-temperature defluorination of PFASs
by Hao Zhang & Jin-Xiang Chen & Jian-Ping Qu & Yan-Biao Kang - 9-9 Author Correction: Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
by Weiguo Fan & Kolade Adebowale & Lóránd Váncza & Yuan Li & Md Foysal Rabbi & Koshi Kunimoto & Dongning Chen & Gergely Mozes & David Kung-Chun Chiu & Yisi Li & Junyan Tao & Yi Wei & Nia Adeniji & Ryan L. Brunsing & Renumathy Dhanasekaran & Aatur Singhi & David Geller & Su Hao Lo & Louis Hodgson & Edgar G. Engleman & Gregory W. Charville & Vivek Charu & Satdarshan P. Monga & Taeyoon Kim & Rebecca G. Wells & Ovijit Chaudhuri & Natalie J. Török - 10-10 Author Correction: Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants
by Zhiqiang Ku & Xuping Xie & Paul R. Hinton & Xinli Liu & Xiaohua Ye & Antonio E. Muruato & Dean C. Ng & Sujit Biswas & Jing Zou & Yang Liu & Deepal Pandya & Vineet D. Menachery & Sachi Rahman & Yu-An Cao & Hui Deng & Wei Xiong & Kevin B. Carlin & Junquan Liu & Hang Su & Elizabeth J. Haanes & Bruce A. Keyt & Ningyan Zhang & Stephen F. Carroll & Pei-Yong Shi & Zhiqiang An - 11-11 Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
by Nobuhiko Kayagaki & Irma B. Stowe & Kamela Alegre & Ishan Deshpande & Shuang Wu & Zhonghua Lin & Opher S. Kornfeld & Bettina L. Lee & Juan Zhang & John Liu & Eric Suto & Wyne P. Lee & Kellen Schneider & WeiYu Lin & Dhaya Seshasayee & Tushar Bhangale & Cecile Chalouni & Matthew C. Johnson & Prajakta Joshi & Jan Mossemann & Sarah Zhao & Danish Ali & Neil M. Goldenberg & Blayne A. Sayed & Benjamin E. Steinberg & Kim Newton & Joshua D. Webster & Ryan L. Kelly & Vishva M. Dixit - 47-47 Glimmers of hope for a deadly disease
by Shraddha Chakradhar - 48-48 Exposing a silent cancer
by Rachel Nuwer - 49-50 Pancreatic cancer is evasive. Is the nervous system the reason why?
by Laura Dattaro - 51-53 The pancreatic cancer models helping to drive innovation in the field
by Rachel Nuwer - 54-56 Early detection could improve pancreatic cancer’s poor survival rates
by Cassandra Willyard - 57-57 A breathalyser-style test for detecting pancreatic cancer
by Esme Hedley - 58-60 Therapeutic vaccines can challenge pancreatic cancer before it takes hold
by Anthony King - 61-62 Six highlights from pancreatic cancer research
by Laura Vargas-Parada - 91-91 Will young universities set the pace in the age of AI?
by Bec Crew - 92-95 What would an AI university look like and how might it change education?
by Jackson Ryan - 96-99 Four young universities share their strategies for success
by Xiaoying You & Benjamin Plackett - 252-252 The Indian Ocean disaster is a climate tragedy — and needs more attention
by Dyna Rochmyaningsih - 253-255 Trump’s AI ‘Genesis Mission’: what are the risks and opportunities?
by Elizabeth Gibney & Alexandra Witze & Jenna Ahart - 255-256 ‘Fire amoeba’ survives in hotter conditions than any other complex cell
by Ewen Callaway - 256-257 Major AI conference flooded with peer reviews written fully by AI
by Miryam Naddaf - 257-258 Has the mysterious ‘compass’ organ of birds been found at last?
by Davide Castelvecchi - 258-259 AlphaFold is five years old — these charts show how it revolutionized science
by Ewen Callaway - 260-260 This is the world’s largest spider web — November’s best science images
by Fred Schwaller & Katie Kavanagh - 262-264 Is your brain tired? Researchers are discovering the roots of mental fatigue
by Lynne Peeples - 265-266 What we eat is making us obese and sick — but science shows solutions are within reach
by Tim Spector - 267-269 How the Royal Institution made science a seasonal spectacle
by Philip Ball - 269-269 Of masks and Mayans: Books in brief
by Andrew Robinson - 270-270 Darleane C. Hoffman obituary: chemist who expanded the periodic table
by Dawn Shaughnessy - 271-274 Food will be more affordable — if we double funds for agriculture research now
by Philip G. Pardey & Connie Chan-Kang & Gert-Jan Stads & Yuan Chai & Julian M. Alston & Jan Greyling & Hernán Muñoz - 275-277 How to get science back into policymaking
by Diane Coyle & Michael Kenny - 278-278 Argentina must finish building the CART radio telescope
by Mariana Orellana - 278-278 Better models are needed to gauge the ecological impacts of reservoirs
by Xingcheng Yan & Sijiu Zhang & Qiuwen Chen & Jianyun Zhang - 278-278 Drug woes won’t be tamed by US price regulations
by Richard Xie - 278-278 Don’t overlook the value of co-supervision in PhD training
by Kok-Siong Poon & Evelyn Siew-Chuan Koay - 279-280 Extreme rainfall poses the biggest risk to Mumbai’s most vulnerable people
by Subimal Ghosh - 280-281 Practical alternative to explosive reaction will improve lab safety
by Tim Schulte & Tobias Ritter - 282-283 T. rex debate settled: contested fossils are smaller rival species, not juveniles
by Lawrence M. Witmer - 283-285 AI discovers learning algorithm that outperforms those designed by humans
by Joel Lehman - 285-286 Nuclear clocks could use electrical signals to keep time
by Xiwen Zhang & Olga Kocharovskaya - 287-288 AI chatbots can persuade voters to change their minds
by Chiara Vargiu & Alessandro Nai - 289-299 The influence of short-lived halogens on atmospheric chemistry and climate
by Alfonso Saiz-Lopez & Anoop S. Mahajan & Jonathan Abbatt & Nicole Bobrowski & Steven S. Brown & John P. Burrows & Lucy J. Carpenter & Martyn P. Chipperfield & Carlos A. Cuevas & Rafael P. Fernandez & Ryan Hossaini & Douglas E. Kinnison & Jean-Francois Lamarque & Barbara J. Finlayson-Pitts & John M. C. Plane & Ulrich Platt & Kerri A. Pratt & A. R. Ravishankara & Ross J. Salawitch & Eric S. Saltzman & William R. Simpson & Susan Solomon & Joel A. Thornton & Tao Wang - 300-305 Laser-based conversion electron Mössbauer spectroscopy of 229ThO2
by Ricky Elwell & James E. S. Terhune & Christian Schneider & Harry W. T. Morgan & Hoang Bao Tran Tan & Udeshika C. Perera & Daniel A. Rehn & Marisa C. Alfonso & Lars von der Wense & Benedict Seiferle & Kevin Scharl & Peter G. Thirolf & Andrei Derevianko & Eric R. Hudson - 312-319 Discovering state-of-the-art reinforcement learning algorithms
by Junhyuk Oh & Gregory Farquhar & Iurii Kemaev & Dan A. Calian & Matteo Hessel & Luisa Zintgraf & Satinder Singh & Hado van Hasselt & David Silver - 320-326 Ferroelectric transistors for low-power NAND flash memory
by Sijung Yoo & Taek Jung Kim & Seung-Geol Nam & Donghoon Kim & Kihong Kim & Yunseong Lee & Moonil Jung & Kwang-Hee Lee & Seokhoon Choi & Seung Dam Hyun & Min-Hyun Lee & Seogwoo Hong & Haesung Kim & Ki Deok Bae & Hyangsook Lee & Jung Yeon Won & Dong-Jin Yun & Byeong Gyu Chae & Wook Ghee Hahn & Chang Hyun Joo & Sanghyun Jo & Yoonsang Park & Kyung Mee Song & Kyooho Jung & Suhwan Lim & Kwangyou Seo & Kwangsoo Kim & Wanki Kim & Daewon Ha & Jee-Eun Yang & Seung-Yeul Yang & Sangwook Kim & Jinseong Heo & Duk-Hyun Choe - 327-332 Quantifying grain boundary deformation mechanisms in small-grained metals
by Romain Gautier & Frédéric Mompiou & Oliver Renk & Christophe Coupeau & Nicolas Combe & Gregory Seine & Marc Legros - 333-340 Accelerating the discovery of multicatalytic cooperativity
by Marcus H. Sak & Richard Y. Liu & Eugene E. Kwan & Eric N. Jacobsen - 341-348 Direct deaminative functionalization with N-nitroamines
by Guangliang Tu & Ke Xiao & Xiaoping Chen & Haoran Xu & Haifeng Zeng & Fangjiang Zhang & Xiao-Song Xue & Xiaheng Zhang - 349-356 Built environment disparities are amplified during extreme weather recovery
by Tianyuan Huang & Chad Zanocco & Zhecheng Wang & Jackelyn Hwang & Ram Rajagopal - 357-367 Nanotyrannus and Tyrannosaurus coexisted at the close of the Cretaceous
by Lindsay E. Zanno & James G. Napoli - 368-376 The evolution of facultative symbiosis in stony corals
by Shani Levy & Xavier Grau-Bové & Iana V. Kim & Sebastian R. Najle & Ewa Księżopolska & Anamaria Elek & Laia Montes-Espuña & Sean A. Montgomery & Tali Mass & Arnau Sebé-Pedrós - 377-382 A global coral phylogeny reveals resilience and vulnerability through deep time
by Claudia Francesca Vaga & Andrea M. Quattrini & Isabela Galvão de Lossio e Seiblitz & Danwei Huang & Zheng Bin Randolph Quek & Jarosław Stolarski & Stephen Douglas Cairns & Marcelo Visentini Kitahara - 383-393 Origins of chromosome instability unveiled by coupled imaging and genomics
by Marco Raffaele Cosenza & Alice Gaiatto & Büşra Erarslan Uysal & Álvaro Andrades & Nina Luisa Sautter & Marina Simunovic & Michael Adrian Jendrusch & Sonia Zumalave & Tobias Rausch & Aliaksandr Halavatyi & Eva-Maria Geissen & Joshua Lucas Eigenmann & Thomas Weber & Patrick Hasenfeld & Eva Benito & Catherine Stober & Isidro Cortes-Ciriano & Andreas E. Kulozik & Rainer Pepperkok & Jan O. Korbel - 394-401 Persuading voters using human–artificial intelligence dialogues
by Hause Lin & Gabriela Czarnek & Benjamin Lewis & Joshua P. White & Adam J. Berinsky & Thomas Costello & Gordon Pennycook & David G. Rand - 402-408 Thiorphan reprograms neurons to promote functional recovery after spinal cord injury
by E. A. van Niekerk & C. Marques de Freria & B. O. Mancarci & K. Groeniger & D. Kulinich & T. Riley & R. Kawaguchi & S. Okawa & T. Vokes & E. S. Rosenzweig & E. Sinopoulou & M. J. Castle & R. Huie & A. R. Ferguson & N. Kfoury-Beaumont & A. Khalessi & P. Pavlidis & M. H. Tuszynski - 409-417 Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
by Domenic Burger & Marianna Kashyrina & Lukas van den Heuvel & Hortense de La Seiglière & Amanda J. Lewis & Francesco De Nuccio & Inayathulla Mohammed & Jérémy Verchère & Cécile Feuillie & Mélanie Berbon & Marie-Laure Arotcarena & Aude Retailleau & Erwan Bezard & Marie-Hélène Canron & Wassilios G. Meissner & Antoine Loquet & Luc Bousset & Christel Poujol & K. Peter R. Nilsson & Florent Laferrière & Thierry Baron & Dario Domenico Lofrumento & Francesca De Giorgi & Henning Stahlberg & François Ichas - 418-426 Transcriptional interferences ensure one olfactory receptor per ant neuron
by Bogdan Sieriebriennikov & Olena Kolumba & Aurore de Beaurepaire & Jennifer Wu & Valentina Fambri & Eva Bardol & Yuwei Zhong & Ildar Gainetdinov & Danny Reinberg & Hua Yan & Claude Desplan - 427-433 Mortality impacts of rainfall and sea-level rise in a developing megacity
by Tom Bearpark & Ashwin Rode & Archana Patankar - 434-442 Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis
by Omer Nadel & Rawad Hanna & Andrey Rozenberg & Dror Shitrit & Ran Tahan & Irena Pekarsky & Oded Béjà & Oded Kleifeld & Debbie Lindell - 443-450 Two residues reprogram immunity receptors for nitrogen-fixing symbiosis
by Magdalini Tsitsikli & Bine Simonsen & Thi-Bich Luu & Maria M. Larsen & Camilla G. Andersen & Kira Gysel & Damiano Lironi & Christina Krönauer & Henriette Rübsam & Simon B. Hansen & René Bærentsen & Jesper Lundsgaard Wulff & Sarah Holt Johansen & Gülendam Sezer & Jens Stougaard & Kasper Røjkjær Andersen & Simona Radutoiu - 451-458 Mapping Plasmodium transitions and interactions in the Anopheles female
by Yan Yan & Lisa H. Verzier & Elaine Cheung & Federico Appetecchia & Sandra March & Ailsa R. Craven & Esrah Du & Alexandra S. Probst & Tasneem A. Rinvee & Laura E. de Vries & Jamie Kauffman & Sangeeta N. Bhatia & Elisabeth Nelson & Naresh Singh & Duo Peng & W. Robert Shaw & Flaminia Catteruccia - 459-467 A skin-permeable polymer for non-invasive transdermal insulin delivery
by Qiuyu Wei & Zhi He & Zifan Li & Zhuxian Zhou & Ying Piao & Jianxiang Huang & Yu Geng & Runnan Zhang & Yaqi Fu & Jiayi Ye & Yue Yuan & Haoru Zhu & Jiaheng Zeng & Yan Zhang & Quan Zhou & Mingyu Xu & Shiqun Shao & Jianbin Tang & Jiajia Xiang & Rongjun Chen & Ruhong Zhou & Youqing Shen - 468-476 Bottom-up design of Ca2+ channels from defined selectivity filter geometry
by Yulai Liu & Connor Weidle & Ljubica Mihaljević & Joseph L. Watson & Zhe Li & Le Tracy Yu & Sagardip Majumder & Andrew J. Borst & Kenneth D. Carr & Ryan D. Kibler & Tamer M. Gamal El-Din & William A. Catterall & David Baker - 477-487 In situ structural mechanism of epothilone-B-induced CNS axon regeneration
by Satish Bodakuntla & Kenichiro Taira & Yurika Yamada & Pelayo Alvarez-Brecht & A. King Cada & Nirakar Basnet & Rui Zhang & Antonio Martinez-Sanchez & Christian Biertümpfel & Naoko Mizuno - 489-490 Five important financial moves for PhD students
by Maddi Langweil - 492-492 Home-field advantage: how local research leads to new discoveries
by Nikki Forrester
December 2025, Volume 648, Issue 8092
- 1-1 Growing cities face mounting challenges
by Richard Hodson - 1-1 Author Correction: Mechanisms of stretch-mediated skin expansion at single-cell resolution
by Mariaceleste Aragona & Alejandro Sifrim & Milan Malfait & Yura Song & Jens Van Herck & Sophie Dekoninck & Souhir Gargouri & Gaëlle Lapouge & Benjamin Swedlund & Christine Dubois & Pieter Baatsen & Katlijn Vints & Seungmin Han & Fadel Tissir & Thierry Voet & Benjamin D. Simons & Cédric Blanpain - 2-2 Author Correction: Brahma safeguards canalization of cardiac mesoderm differentiation
by Swetansu K. Hota & Kavitha S. Rao & Andrew P. Blair & Ali Khalilimeybodi & Kevin M. Hu & Reuben Thomas & Kevin So & Vasumathi Kameswaran & Jiewei Xu & Benjamin J. Polacco & Ravi V. Desai & Nilanjana Chatterjee & Austin Hsu & Jonathon M. Muncie & Aaron M. Blotnick & Sarah A. B. Winchester & Leor S. Weinberger & Ruth Hüttenhain & Irfan S. Kathiriya & Nevan J. Krogan & Jeffrey J. Saucerman & Benoit G. Bruneau - 2-4 How cities can keep their cool
by Michael Eisenstein - 3-3 Author Correction: A metallic p-wave magnet with commensurate spin helix
by Rinsuke Yamada & Max T. Birch & Priya R. Baral & Shun Okumura & Ryota Nakano & Shang Gao & Motohiko Ezawa & Takuya Nomoto & Jan Masell & Yuki Ishihara & Kamil K. Kolincio & Ilya Belopolski & Hajime Sagayama & Hironori Nakao & Kazuki Ohishi & Takashi Ohhara & Ryoji Kiyanagi & Taro Nakajima & Yoshinori Tokura & Taka-hisa Arima & Yukitoshi Motome & Moritz M. Hirschmann & Max Hirschberger - 4-4 Author Correction: AIM2 in regulatory T cells restrains autoimmune diseases
by Wei-Chun Chou & Zengli Guo & Hao Guo & Liang Chen & Ge Zhang & Kaixin Liang & Ling Xie & Xianming Tan & Sara A. Gibson & Elena Rampanelli & Yan Wang & Stephanie A. Montgomery & W. June Brickey & Meng Deng & Leslie Freeman & Song Zhang & Maureen A. Su & Xian Chen & Yisong Y. Wan & Jenny P.-Y. Ting - 5-7 Cities are embracing nature for flood defence
by Erica Gies - 8-8 Great science happens in great teams — research assessments must try to capture that
by David Budtz Pedersen - 8-10 Wooden skyscrapers point the way to more sustainable cities
by Sedeer el-Showk - 9-9 AI reviewers are here — we are not ready
by Giorgio F. Gilestro - 11-11 Building mentally healthy cities with neuroscience
by Simon Makin - 11-13 What happened at COP30? 4 science take-homes from the climate summit
by Meghie Rodrigues & Jeff Tollefson - 12-12 Cities aren’t built for women — it’s time to change that
by Leslie Kern - 13-13 Cyberattacks’ harm to universities is growing — and so are their effects on research
by Diana Kwon - 13-15 Data drive city transportation forwards
by Neil Savage - 14-15 A brain implant that could rival Neuralink’s enters clinical trials
by Liam Drew - 15-16 ‘Anti-woke’ policies blamed for falling attendance at some US conferences
by Alexandra Witze - 16-17 ‘They don’t have symptoms’: CAR-T therapies send autoimmune diseases into remission
by Rachel Fieldhouse - 16-18 Geothermal networks let cities warm and cool as one
by Peter Fairley - 17-17 Synthetic tongue rates chillies’ heat — and spares human tasters
by Jenna Ahart - 18-18 We are all mosaics: vast genetic diversity found between cells in a single person
by Heidi Ledford - 20-22 Will blockbuster obesity drugs revolutionize addiction treatment?
by Elie Dolgin - 23-25 The ‘silent’ brain cells that shape our behaviour, memory and health
by Alison Abbott - 26-27 Nature at its weirdest: what metamorphosis reveals about science and ourselves
by Itai Yanai - 28-30 Spineless creatures, possibly the world’s oldest beer receipt and more: 2025’s best Books in brief
by Andrew Robinson - 31-31 David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
by Stephen Goff - 33-34 A ten-year drive to credit authors for their work — and why there’s still more to do
by Liz Allen & Veronique Kiermer & Simon Porter & Ruth Whittam - 35-37 Why universities need to radically rethink exams in the age of AI
by Vitomir Kovanović & Abhinava Barthakur & Srećko Joksimović & George Siemens - 38-38 Alternatives to animal research are not inherently more ethical
by Michele A. Basso - 38-38 Drinking water is at risk during warfare — better protections are needed
by Rongsheng Ning & Yingying Xiang & Mauricius Marques dos Santos & Shane A. Snyder - 38-38 Memes reveal threats to graduate-student mental health
by Samuel Paulo Cibulski - 38-38 Ease the EU postdoc job market with better routes to innovation
by Bram Servais - 39-40 Fall-prevention clinical trial in rural China shows promising results
by Cynthia Swarnalatha & Sallie E. Lamb - 40-42 Still no sign of hypothetical sterile-neutrino particle
by Patrick Huber - 42-43 Even in space, telescopes can’t escape photobombers
by Meredith Rawls - 43-45 Stop the nonsense: genome editing creates potentially therapeutic transfer RNAs
by Kim M. Keeling - 45-46 Ethically sourced image data set encourages fairness in AI research
by Walter J. Scheirer - 46-48 Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity
by Marc P. Stemmler - 48-49 Quarks in ‘exotic’ quartets prefer to stick together
by Elena Santopinto - 49-50 Taiwan invests in genetic resource for health
by Genevieve L. Wojcik - 51-57 Satellite megaconstellations will threaten space-based astronomy
by Alejandro S. Borlaff & Pamela M. Marcum & Steve B. Howell - 76-83 Glasses-free 3D display with ultrawide viewing range using deep learning
by Weijie Ma & Zhangrui Zhao & Canyu Zhao & Wanli Ouyang & Han-Sen Zhong - 84-90 Tin-based perovskite solar cells with a homogeneous buried interface
by Tianpeng Li & Xin Luo & Peilin Wang & Zhi Li & Yimeng Li & Jinhai Huang & Zuoming Jin & Yingguo Yang & Bin Li & Wenqi Zhang & Siyuan Lin & Yichuan Rui & Hua Wang & Qinghong Zhang & Yiqiang Zhan & Bo Xu & Jia Liang & Yabing Qi - 91-96 A matrix-confined molecular layer for perovskite photovoltaic modules
by Yugang Liang & Guodong Chen & Yao Wang & Yu Zou & Menglei Feng & Yanming Wang & Bowei Li & Yuljae Cho & Yide Chang & Tianle Liu & Taiyang Zhang & Yongbing Lou & Ranran Xu & Lei Lu & Ni Zhang & Ke Meng & Chen Zhu & Chuying Ouyang & Yanfeng Miao & Yongsheng Guo & Yuetian Chen & Yixin Zhao - 97-108 Fair human-centric image dataset for ethical AI benchmarking
by Alice Xiang & Jerone T. A. Andrews & Rebecca L. Bourke & William Thong & Julienne M. LaChance & Tiffany Georgievski & Apostolos Modas & Aida Rahmattalabbi & Yunhao Ba & Shruti Nagpal & Orestis Papakyriakopoulos & Dora Zhao & Jinru Xue & Victoria Matthews & Linxia Gong & Austin T. Hoag & Mircea Cimpoi & Swami Sankaranarayanan & Wiebke Hutiri & Morgan K. Scheuerman & Albert S. Abedi & Peter Stone & Peter R. Wurman & Hiroaki Kitano & Michael Spranger - 109-116 Co-option of an ancestral cloacal regulatory landscape during digit evolution
by Aurélie Hintermann & Christopher C. Bolt & M. Brent Hawkins & Guillaume Valentin & Lucille Lopez-Delisle & Madeline M. Ryan & Sandra Gitto & Paula Barrera Gómez & Bénédicte Mascrez & Thomas A. Mansour & Tetsuya Nakamura & Matthew P. Harris & Neil H. Shubin & Denis Duboule - 117-127 The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies
by Hsin-Chou Yang & Pui-Yan Kwok & Ling-Hui Li & Yi-Min Liu & Yuh-Jyh Jong & Kang-Yun Lee & Da-Wei Wang & Ming-Fang Tsai & Jenn-Hwai Yang & Chien-Hsiun Chen & Erh-Chan Yeh & Chun-yu Wei & Cathy S.-J. Fann & Yen-Tsung Huang & Chia-Wei Chen & Yi-Ju Lee & Shih-Kai Chu & Chih-hsing Ho & Cheng-Shin Yang & Yungling Leo Lee & Hung-Hsin Chen & Ming-Chih Hou & Jeng-Fong Chiou & Shun-Fa Yang & Chih-Hung Wang & Chih-Yang Huang & Kuan-Ming Chiu & Ming Chen & Fu-Tien Chiang & Sing-Lian Lee & Shiou-Sheng Chen & Wei-Jen Yao & Chih-Cheng Chien & Shih-Yao Lin & Fu-Pang Chang & Hsiang-Ling Ho & Yi-Chen Yeh & Wei-Cheng Tseng & Ming-Hwai Lin & Hsiao-Ting Chang & Ling-Ming Tseng & Wen-Yih Liang & Paul Chih-Hsueh Chen & Jen-Fan Hang & Shih-Chieh Lin & Yu-Jiun Chan & Ying-Ju Kuo & Lei-Chi Wang & Chin-Chen Pan & Yu-Cheng Hsieh & Yi-Ming Chen & Tzu-Hung Hsiao & Ching-Heng Lin & Yen-Ju Chen & I-Chieh Chen & Chien-Lin Mao & Shu-Jung Chang & Yen-Lin Chang & Yi-Ju Liao & Chih-Hung Lai & Wei-Ju Lee & Hsin Tung & Ting-Ting Yen & Hsin-Chien Yen & Chun-Ming Shih & Teh-Ying Chou & Tsan-Hon Liou & Chen-Yuan Chiang & Yih-Giun Cherng & Chih-Hwa Chen & Chao-Hua Chiu & Sung-Hui Tseng & Emily Pei-Ying Lin & Ying-Ju Chen & Hui-Ping Chuang & Tsai-Chuan Chen & Wei-Ting Huang & Joey Sin & I-Ling Liu & Yi-Chen Chen & Kuo-Kuang Chao & Yu-Min Wu & Pin-Pin Yu & Lung-Pao Chang & Kuei-Yao Yen & Li-Ching Chang & Yi-Jing Sheen & Yuan-Tsong Chen & Kamhon Kan & Hsiang-Lin Tsai & Yao-Kuang Wang & Ming-Feng Hou & Yuan-Han Yang & Chao-Hung Kuo & Wen-Jeng Wu & Jee-Fu Huang & Inn-Wen Chong & Jong-Rung Tsai & Cheng-Yu Lin & Ming-Chin Yu & Tsong-Hai Lee & Meng-Han Tsai & Yu-Che Ou & Pin-Yuan Chen & Tsung-Hui Hu & Yu-Chiau Shyu & Chih-Kuang Cheng & Yu-Jen Fang & Song-Chou Hsieh & Chien-Hung Chen & Chieh-Chang Chen & Ko-Jen Li & Chin-Hsien Lin & Hsien-Yi Chiu & Chen-Chi Wu & Chun-Yen Chen & Shi-Jye Chu & Feng-Cheng Liu & Fu-Chi Yang & Hsin-An Chang & Wei-liang Chen & Sung-Sen Yang & Yueh-feng Sung & Tso-Fu Wang & Shinn-Zong Lin & Yen-Wen Wu & Chien-Sheng Wu & Ju-Ying Jiang & Gwo-Chin Ma & Ting-Yu Chang & Juey-Jen Hwang & Kuo-Jang Kao & Chen-Fang Hung & Ting-Fang Chiu & Po-Yueh Chen & Kochung Tsui & Ming-Shiang Wu & See-Tong Pang & Shih-Ann Chen & Wei-Ming Chen & Chun-houh Chen & Wayne Huey-Herng Sheu & Jer-Yuarn Wu - 128-137 Population-specific polygenic risk scores for people of Han Chinese ancestry
by Hung-Hsin Chen & Chien-Hsiun Chen & Ming-Chih Hou & Yun-Ching Fu & Ling-Hui Li & Che-Yu Chou & Erh-Chan Yeh & Ming-Fang Tsai & Chun-houh Chen & Hsin-Chou Yang & Yen-Tsung Huang & Yi-Min Liu & Chun-yu Wei & Jen-Ping Su & Wan-Jia Lin & Elin H. F. Wang & Chi-Lu Chiang & Jeng-Kai Jiang & I-Hui Lee & Kung-Hao Liang & Wei-Sheng Chen & Hung-Cheng Tsai & Shih-Yao Lin & Fu-Pang Chang & Hsiang-Ling Ho & Yi-Chen Yeh & Wei-Cheng Tseng & Ming-Hwai Lin & Hsiao-Ting Chang & Ling-Ming Tseng & Wen-Yih Liang & Paul Chih-Hsueh Chen & Yu-Cheng Hsieh & Yi-Ming Chen & Tzu-Hung Hsiao & Ching-Heng Lin & Yen-Ju Chen & I-Chieh Chen & Chien-Lin Mao & Shu-Jung Chang & Yen-Lin Chang & Yi-Ju Liao & Chih-Hung Lai & Wei-Ju Lee & Hsin Tung & Ting-Ting Yen & Hsin-Chien Yen & Ming-Yao Chen & Ying-Chin Lin & Yung-Ta Kao & Bi-Zhen Kao & Jing-Er Lee & Chi-Li Chung & Ju-Chi Liu & Paul Chan & Chang-Hsien Lin & Chia-Hsin Chen & I-Chen Wu & Lung-Chang Lin & Jiunn-Wei Wang & Shen-liang Shih & Sun-Wung Hsieh & Chih-Hsing Hung & Wei-Ming Li & Chih-Jen Yang & Cheng-Shin Yang & Ru-Hui Weng & Yu-Chi Chen & Chun-Ping Chang & Tai-Hsun Wu & Yu-Chang Lin & Yi-Jing Sheen & Shi-Heng Wang & Sye-Pu Chen & Timothy Raben & Erik Widen & Stephen Hsu & Feng-Jen Hsieh & Dong-Ru Ho & Yu-Huei Huang & Chung-Han Yang & Yu-Shu Huang & Yen-Fu Chen & Hsien-Ming Wu & Ping-Han Tsai & Kuan-Gen Huang & Chih-Yen Chien & Yi-Lwun Ho & Ming-Shiang Wu & Jia-Horng Kao & Yen-Bin Liu & Jyh-Ming Jimmy Juang & Mao-Hsin Lin & Yen-Hung Lin & Ji-Yuh Lee & Hsueh-Ju Lu & Chieh-Hua Lu & An-Chieh Feng & Jhih-Syuan Liu & Chien-Ping Chiang & Nain-Feng Chu & Jung-Chun Lin & Yi-Wei Yeh & En Meng & Chih-Yang Huang & Chi-Cheng Li & Tso-Fu Wang & Kuei-Ying Su & Jia-Kang Wang & Mei-Hsiu Chen & Hua-Fen Chen & Gwo-Chin Ma & Ting-Yu Chang & Fu-Tien Chiang & Hsing-Jung Chang & Kuo-Jang Kao & Chen-Fang Hung & Ching-Yao Tsai & Po-Yueh Chen & Kochung Tsui & Yuan-Tsong Chen & Pui-Yan Kwok & Wayne Huey-Herng Sheu & Shun-Fa Yang & Jyh-Ming Liou & Jaw-Yuan Wang & Jeng-Fong Chiou & Jer-Yuarn Wu & Cathy S. J. Fann - 138-145 Integration of hunger and hormonal state gates infant-directed aggression
by Mingran Cao & Rachida Ammari & Maxwell X. Chen & Patty Wai & Bradley B. Jamieson & Swang Liang & Basma F. A. Husain & Aashna Sahni & Nathalie Legrave & Irene Salgarella & James MacRae & Molly Strom & Johannes Kohl - 146-156 The astrocytic ensemble acts as a multiday trace to stabilize memory
by Ken-ichi Dewa & Kodai Kaseda & Aoi Kuwahara & Hideaki Kubotera & Ayato Yamasaki & Natsumi Awata & Atsuko Komori & Mika A. Holtz & Atsushi Kasai & Henrik Skibbe & Norio Takata & Tatsushi Yokoyama & Makoto Tsuda & Genri Numata & Shun Nakamura & Eiki Takimoto & Masayuki Sakamoto & Minako Ito & Takahiro Masuda & Jun Nagai - 157-165 Lymphoid gene expression supports neuroprotective microglia function
by Pinar Ayata & Jessica M. Crowley & Matthew F. Challman & Vinaya Sahasrabuddhe & Maud Gratuze & Sebastian Werneburg & Diogo Ribeiro & Emma C. Hays & Violeta Durán-Laforet & Travis E. Faust & Philip Hwang & Francisco Mendes Lopes & Chrysa Nikopoulou & Sarah Buchholz & Robert E. Murphy & Taoyu Mei & Anna A. Pimenova & Carmen Romero-Molina & Francesca Garretti & Tulsi A. Patel & Claudia De Sanctis & Angie V. Ramirez Jimenez & Megan Crow & Felix D. Weiss & Jason D. Ulrich & Edoardo Marcora & John W. Murray & Felix Meissner & Andreas Beyer & Dan Hasson & John F. Crary & Dorothy P. Schafer & David M. Holtzman & Alison M. Goate & Alexander Tarakhovsky & Anne Schaefer - 166-172 Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
by Giovanni Luchetti & Marin V. Miner & Rachael M. Peterson & William P. Scott & Praveen Krishnamoorthy & Eric M. Kofoed & Angel G. Jimenez & Hua Zhang & Man Wah Tan & Rohit Reja & Tommy K. Cheung & Elizabeth Skippington & Yuxin Liang & Christopher M. Rose & Nobuhiko Kayagaki & Kim Newton & Isabella Rauch & Vishva M. Dixit - 173-181 Niche-specific dermal macrophage loss promotes skin capillary ageing
by Kailin R. Mesa & Kevin A. O’Connor & Charles Ng & Steven P. Salvatore & Alexandra Dolynuk & Michelle Rivera Lomeli & Dan R. Littman - 182-190 Spatial metabolic gradients in the liver and small intestine
by Laith Z. Samarah & Clover Zheng & Xi Xing & Won Dong Lee & Amichay Afriat & Uthsav Chitra & Michael R. MacArthur & Wenyun Lu & Connor S. R. Jankowski & Cong Ma & Craig J. Hunter & Michael Neinast & Daniel R. Weilandt & Benjamin J. Raphael & Joshua D. Rabinowitz - 191-202 Prime editing-installed suppressor tRNAs for disease-agnostic genome editing
by Sarah E. Pierce & Steven Erwood & Keyede Oye & Meirui An & Nicholas Krasnow & Emily Zhang & Aditya Raguram & Davis Seelig & Mark J. Osborn & David R. Liu - 203-209 SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
by Huafu Li & Linxiang Lan & Hengxing Chen & May Zaw Thin & Hari Ps & Jessica K. Nelson & Ian M. Evans & E. Josue Ruiz & Rongjie Cheng & Li Tran & Mark Allen & Jian Ma & Tingzhuang Yi & Chunming Wang & Yulong He & Naomi Guppy & Anguraj Sadanandam & Shao-Zhen Lin & Changhua Zhang & Axel Behrens - 210-219 KCTD10 is a sensor for co-directional transcription–replication conflicts
by Jake A. Kloeber & Bin Chen & Guangchao Sun & Charles S. King & Zhiquan Wang & Li Wang & Zheming Wu & Shouhai Zhu & Fei Zhao & Hongran Qin & Yaobin Ouyang & Huaping Xiao & Xinyi Tu & Jing Lu & Yanxia Jiang & Kuntian Luo & Ping Yin & Xinyan Wu & Robert W. Mutter & Jinzhou Huang & Zhenkun Lou - 220-228 Mechanism of conductance control and neurosteroid binding in NMDA receptors
by Hyunook Kang & Ruben Steigerwald & Elijah Z. Ullman & Max Epstein & Srinu Paladugu & Dennis C. Liotta & Stephen F. Traynelis & Hiro Furukawa - 229-238 Designing allosteric modulators to change GPCR G protein subtype selectivity
by Madelyn N. Moore & Kelsey L. Person & Valeria L. Robleto & Abigail R. Alwin & Campbell L. Krusemark & Noah Foster & Caroline Ray & Asuka Inoue & Michael R. Jackson & Michael J. Sheedlo & Lawrence S. Barak & Ezequiel Marron Fernandez de Velasco & Steven H. Olson & Lauren M. Slosky - 239-240 Lessons from a long road to a first-author paper
by Poojashree Chettiar - 240-241 Introducing the j-metric: a true measure of what matters in academia
by Dariusz Jemielniak - 244-244 Climbing through the silver mine: my work as a geologist
by Dave Tacon
November 2025, Volume 647, Issue 8091
- 4-4 Author Correction: Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche
by Meryem B. Baghdadi & David Castel & Léo Machado & So-ichiro Fukada & David E. Birk & Frederic Relaix & Shahragim Tajbakhsh & Philippos Mourikis - 5-5 Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
by Manolis Pasparakis & Gilles Courtois & Martin Hafner & Marc Schmidt-Supprian & Arianna Nenci & Atiye Toksoy & Monika Krampert & Matthias Goebeler & Reinhard Gillitzer & Alain Israel & Thomas Krieg & Klaus Rajewsky & Ingo Haase - 6-6 Author Correction: The emergence of transcriptional identity in somatosensory neurons
by Nikhil Sharma & Kali Flaherty & Karina Lezgiyeva & Daniel E. Wagner & Allon M. Klein & David D. Ginty - 7-7 Author Correction: The oldest known lepidosaur and origins of lepidosaur feeding adaptations
by Daniel Marke & David I. Whiteside & Thitiwoot Sethapanichsakul & Robert A. Coram & Vincent Fernandez & Alexander Liptak & Elis Newham & Michael J. Benton - 8-8 Author Correction: Learning the natural history of human disease with generative transformers
by Artem Shmatko & Alexander Wolfgang Jung & Kumar Gaurav & Søren Brunak & Laust Hvas Mortensen & Ewan Birney & Tom Fitzgerald & Moritz Gerstung - 9-9 Publisher Correction: Radiation-induced amphiregulin drives tumour metastasis
by András Piffkó & Kaiting Yang & Arpit Panda & Janna Heide & Krystyna Tesak & Chuangyu Wen & Katarzyna Zawieracz & Liangliang Wang & Emile Z. Naccasha & Jason Bugno & Yanbin Fu & Dapeng Chen & Leonhard Donle & Ernst Lengyel & Douglas G. Tilley & Matthias Mack & Ronald S. Rock & Steven J. Chmura & Everett E. Vokes & Chuan He & Sean P. Pitroda & Hua Laura Liang & Ralph R. Weichselbaum - 27-29 How to stop the revolving door of German academia
by Diana Kwon