Content
December 2025, Volume 16, Issue 1
- 1-25 Defective Olfactomedin-2 connects adipocyte dysfunction to obesity
by Aina Lluch & Jèssica Latorre & Isabel Espadas & Núria Oliveras-Cañellas & José M. Moreno-Navarrete & Estefanía Caballano-Infantes & Gitalee Sarker & Nicolás F. Malvido & Pablo Garrido-Gil & José L. Labandeira-García & Naoki Nakaya & Silvia Mora & Eduardo Chicano & Jaime López-Alcalá & María M. Malagón & Alejandro Martín-Montalvo & Birong Zhang & You Zhou & Ana I. Domingos & Miguel López & Johanna Pörschke & María Gómez-Serrano & Witold Szymanski & Johannes Graumann & Stanislav I. Tomarev & Ismael González-García & José M. Fernández-Real & Francisco J. Ortega - 1-25 Genkwanin glycosides are major active compounds in Phaleria nisidai extract mediating improved glucose homeostasis by stimulating glucose uptake into adipose tissues
by Carla Horvath & Joëlle Houriet & Alexandra Kellenberger & Caroline Moser & Lucia Balazova & Miroslav Balaz & Hua Dong & Aron Horvath & Isabel Reinisch & Vissarion Efthymiou & Adriano Rutz & Laurence Marcourt & Christopher Kitalong & Bertrand Graz & Victor Yano & Emerson Ferreira Queiroz & Jean-Luc Wolfender & Christian Wolfrum - 1-25 Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites
by Yun Teng & Chao Luo & Xiaolan Qiu & Jingyao Mu & Mukesh K. Sriwastva & Qingbo Xu & Minmin Liu & Xin Hu & Fangyi Xu & Lifeng Zhang & Juw Won Park & Jae Yeon Hwang & Maiying Kong & Zhanxu Liu & Xiang Zhang & Raobo Xu & Jun Yan & Michael L. Merchant & Craig J. McClain & Huang-Ge Zhang - 1-25 IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells
by Jan-Inge Bjune & Samantha Laber & Laurence Lawrence-Archer & Patrizia M. C. Nothnagel & Shuntaro Yamada & Xu Zhao & Pouda Panahandeh Strømland & Niyaz Al-Sharabi & Kamal Mustafa & Pål R. Njølstad & Melina Claussnitzer & Roger D. Cox & Pierre Chymkowitch & Gunnar Mellgren & Simon N. Dankel - 1-25 Molecular logic for cellular specializations that initiate the auditory parallel processing pathways
by Junzhan Jing & Ming Hu & Tenzin Ngodup & Qianqian Ma & Shu-Ning Natalie Lau & M. Cecilia Ljungberg & Matthew J. McGinley & Laurence O. Trussell & Xiaolong Jiang - 1-25 Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug
by Naohiko Okabe & Xiaofei Wei & Farah Abumeri & Jonathan Batac & Mary Hovanesyan & Weiye Dai & Srbui Azarapetian & Jesus Campagna & Nadia Pilati & Agostino Marasco & Giuseppe Alvaro & Martin J. Gunthorpe & John Varghese & Steven C. Cramer & Istvan Mody & S. Thomas Carmichael - 1-25 Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
by Virginia Gao & Julita Chlebowicz & Karlton Gaskin & Juan A. Briano & Lauren E. Komer & André Pineda & Shrey Jhalani & Saad Ahmad & Eseosa Uwaifo & Luca S. Black & Jillian E. Haller & Serge Przedborski & Diane A. Lane & Sheng Zhang & Manu Sharma & Jacqueline Burré - 1-25 Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes
by Kai He & Xue Dong & Tianjing Yang & Ziqi Li & Yuming Liu & Jing He & Meng Wu & Selena Wei-Zhang & Parhat Kaysar & Bohao Cui & Xueming Yao & Li Zhang & Wei Zhou & Heping Xu & Jun Wei & Qiang Liu & Junhao Hu & Xiaohong Wang & Hua Yan - 1-25 Building lactams by highly selective hydrodeoxygenation of cyclic imides using an alumina-supported AgRe bimetallic nanocatalyst
by Carles Lluna-Galán & Juan Camilo Arango-Daza & Daviel Gómez & Patricia Concepción & Rong Sun & Jose J. Calvino & Laura Simonelli & Rosa Adam & Jose R. Cabrero-Antonino - 1-25 Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission
by Joshua G. Pemberton & Krishnendu Roy & Yeun Ju Kim & Tara D. Fischer & Vijay Joshi & Elizabeth Ferrer & Richard J. Youle & Thomas J. Pucadyil & Tamas Balla - 1-25 MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer
by Junlong Jack Chi & Ping Xie & Mary Hongying Cheng & Yueming Zhu & Xin Cui & Joshua Watson & Lidan Zeng & Amad Uddin & Hoang Nguyen & Lei Li & Kelley Moremen & April Reedy & Megan Wyatt & Adam Marcus & Mingji Dai & Chrystal M. Paulos & Massimo Cristofanilli & William J. Gradishar & Shaying Zhao & Kevin Kalinsky & Mine-Chie Hung & Ivet Bahar & Bin Zhang & Yong Wan - 1-25 Human endothelial cells promote a human neural stem cell type B phenotype via Notch signaling
by Brenda Gutierrez & Tzu Chia Liu & Carly Rodriguez & Oier Pastor-Alonso & Hannah Lambing & Mercedes F. Paredes & Lisa A. Flanagan - 1-25 Metabolism archetype cancer cells induce protumor TREM2+ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma
by Tianhao Chu & Guiqi Zhu & Zheng Tang & Weifeng Qu & Rui Yang & Haiting Pan & Yi Wang & Ruilin Tian & Leilei Chen & Zhiqi Guan & Yichao Bu & Qianfu Zhao & Jiafeng Chen & Shengwei Mao & Yuan Fang & Jun Gao & Xiaoling Wu & Jian Zhou & Weiren Liu & Dan Ye & Jia Fan & Yinghong Shi - 1-25 Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility
by Xiaohan Zhang & Arghya Mukherjee & Michael M. Halassa & Zhe Sage Chen - 1-25 Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke
by Xiao He & Jiadong Chen & Yan Zhong & Peili Cen & Li Shen & Fei Huang & Jing Wang & Chentao Jin & Rui Zhou & Xiaohui Zhang & Anxin Wang & Jing Fan & Shuang Wu & Mengjiao Tu & Xiyi Qin & Xiaoyun Luo & Yu Zhou & Jieqiao Peng & Youyou Zhou & A. Cahid Civelek & Mei Tian & Hong Zhang - 1-25 Border-zone cardiomyocytes and macrophages regulate extracellular matrix remodeling to promote cardiomyocyte protrusion during cardiac regeneration
by Florian Constanty & Bailin Wu & Ke-Hsuan Wei & I-Ting Lin & Julia Dallmann & Stefan Guenther & Till Lautenschlaeger & Rashmi Priya & Shih-Lei Lai & Didier Y. R. Stainier & Arica Beisaw - 1-25 Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs
by Yangkang Zheng & Lin Cong & Li Zhao & Pengyu Wang & Lianping Xing & Junling Liu & Hao Xu & Ning Li & Yongjian Zhao & Luying Yuan & Qi Shi & Xueqing Sun & Qianqian Liang & YongJun Wang - 1-25 Heterogeneity-preserving discriminative feature selection for disease-specific subtype discovery
by Abdur Rahman M. A. Basher & Caleb Hallinan & Kwonmoo Lee - 1-26 Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers
by Kai Li & Xuan Yu & Yanteng Xu & Haixia Wang & Zheng Liu & Chong Wu & Xing Luo & Jiancheng Xu & Youqiang Fang & Enguo Ju & Shixian Lv & Hon Fai Chan & Yeh-Hsing Lao & Weiling He & Yu Tao & Mingqiang Li - 1-26 DOLPHIN advances single-cell transcriptomics beyond gene level by leveraging exon and junction reads
by Kailu Song & Yumin Zheng & Bowen Zhao & David H. Eidelman & Jian Tang & Jun Ding - 1-26 Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies
by Robert D. Meade & Ashley P. Akerman & Sean R. Notley & Gregory W. McGarr & Emma R. McCourt & Nathalie V. Kirby & Joseph T. Costello & James D. Cotter & Craig G. Crandall & Antonella Zanobetti & Glen P. Kenny - 1-26 ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche
by Hua Jiang & Denggang Fu & Santhosh Kumar Pasupuleti & Baskar Ramdas & Alan Long & Abdulraouf M. Ramadan & Jinfeng Yang & Ramesh Kumar & Jessica H. Hartman & B. Jacob Kendrick & Ed Simpson & Hongyu Gao & Yunlong Liu & Drew Moore & Suganya Subramanian & Stefano Berto & Anilkumar Gopalakrishnapillai & Sonali P. Barwe & Hongfen Guo & Nai-Kong V. Cheung & Reuben Kapur & Sophie Paczesny - 1-26 Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers
by Brandon M. Lehrich & Evan R. Delgado & Tyler M. Yasaka & Silvia Liu & Catherine Cao & Yuqing Liu & Mohammad N. Taheri & Xiangnan Guan & Hartmut Koeppen & Sucha Singh & Vik Meadows & Jia-Jun Liu & Anya Singh-Varma & Yekaterina Krutsenko & Minakshi Poddar & T. Kevin Hitchens & Lesley M. Foley & Binyong Liang & Alex Rialdi & Ravi P. Rai & Panari Patel & Madeline Riley & Aaron Bell & Reben Raeman & Tulin Dadali & Jason J. Luke & Ernesto Guccione & Mo R. Ebrahimkhani & Amaia Lujambio & Xin Chen & Martin Maier & Yulei Wang & Wendy Broom & Junyan Tao & Satdarshan P. Monga - 1-26 Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking
by Esther González-Almela & Alvaro Castells-Garcia & François Dily & Manuel Fernández Merino & Davide Carnevali & Pol Cusco & Luciano Croce & Maria Pia Cosma - 1-26 A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma
by Yingying Zhao & Hongmei Yu & Jiajun Li & Jiali Qian & Miao Li & Xi Zhang & Mimi Wang & Yaohui Wang & Yinying Dong & Yang You & Qiwen Zhou & Dongmei Gao & Yan Zhao & Binbin Liu & Rongxin Chen & Zhenggang Ren & Zhiming Wang & Kezhi Zhang & Jiefeng Cui - 1-26 Striatal arbitration between choice strategies guides few-shot adaptation
by Minsu Abel Yang & Min Whan Jung & Sang Wan Lee - 1-26 Topological identification and interpretation for single-cell epigenetic regulation elucidation in multi-tasks using scAGDE
by Gaoyang Hao & Yi Fan & Zhuohan Yu & Yanchi Su & Haoran Zhu & Fuzhou Wang & Xingjian Chen & Yuning Yang & Guohua Wang & Ka-chun Wong & Xiangtao Li - 1-26 Distinct subnetworks of the mouse anterior thalamic nuclei
by Houri Hintiryan & Mitchell Rudd & Sumit Nanda & Adriana E. Gutierrez & Darrick Lo & Tyler Boesen & Luis Garcia & Jiandong Sun & Christian Estrada & Hyun-Seung Mun & Seita Yamashita & Yeji E. Han & Ian Bowman & Lin Gou & Chunru Cao & Jennifer Gonzalez & Keivan Moradi & Qiuying Zhao & Inga Yenokian & Aishwarya Dev & Brian Zingg & Hanpeng Xu & Qing Xue & Muye Zhu & Lijuan Liu & Xin Chen & Zhixi Yun & Hanchuan Peng & Nicholas N. Foster & Hong-Wei Dong - 1-26 Advancing spatio-temporal processing through adaptation in spiking neural networks
by Maximilian Baronig & Romain Ferrand & Silvester Sabathiel & Robert Legenstein - 1-26 Genetic coupling of enhancer activity and connectivity in gene expression control
by Helen Ray-Jones & Chak Kei Sung & Lai Ting Chan & Alexander Haglund & Pavel Artemov & Monica Della Rosa & Luminita Ruje & Frances Burden & Roman Kreuzhuber & Anna Litovskikh & Eline Weyenbergh & Zoï Brusselaers & Vanessa Xue Hui Tan & Mattia Frontini & Chris Wallace & Valeriya Malysheva & Leonardo Bottolo & Elena Vigorito & Mikhail Spivakov - 1-26 Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking
by Man-Xiu Xie & Ren-Chun Lai & Yi-Bin Xiao & Shi-Yu Zuo & Hao Tang & Xian-Ying Cao & Jin-Kun Liu & Zi-Su Zhou & Shu-Hang Wang & Xiao-Fan Lu & Ying He & Yan Xie & Xiao-Long Zhang - 1-27 Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
by Hongyu Chen & Ruifeng Xu & Jianhao Wang & Feng Gao & Yida Lv & Xiang Li & Fang Li & Junqin Zhao & Xi Zhang & Jiabei Wang & Ruicheng Du & Yuke Shi & Hang Yu & Shuai Ding & Wenxin Li & Jing Xiong & Jie Zheng & Liang Zhao & Xin-Ya Gao & Zhi-Hao Wang - 1-27 Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolution
by Nathalie Van Acker & François-Xavier Frenois & Pauline Gravelle & Marie Tosolini & Charlotte Syrykh & Camille Laurent & Pierre Brousset - 1-27 Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance
by George F. Hoeferlin & Sarah E. Grabinski & Lindsey N. Druschel & Jonathan L. Duncan & Grace Burkhart & Gwendolyn R. Weagraff & Alice H. Lee & Christopher Hong & Meera Bambroo & Hannah Olivares & Tejas Bajwa & Jennifer Coleman & Longshun Li & William Memberg & Jennifer Sweet & Hoda Amani Hamedani & Abhinav P. Acharya & Ana G. Hernandez-Reynoso & Curtis Donskey & George Jaskiw & E. Ricky Chan & Andrew J. Shoffstall & A. Bolu Ajiboye & Horst A. Recum & Liangliang Zhang & Jeffrey R. Capadona - 1-27 Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons
by Nolan M. Dvorak & Paul A. Wadsworth & Guillermo Aquino-Miranda & Pingyuan Wang & Douglas S. Engelke & Jingheng Zhou & Nghi Nguyen & Aditya K. Singh & Giuseppe Aceto & Zahra Haghighijoo & Isabella I. Smith & Nana Goode & Mingxiang Zhou & Yosef Avchalumov & Evan P. Troendle & Cynthia M. Tapia & Haiying Chen & Reid T. Powell & Timothy J. Baumgartner & Jully Singh & Leandra Koff & Jessica Re & Ann E. Wadsworth & Mate Marosi & Marc R. Azar & Kristina Elias & Paul Lehmann & Yorkiris M. Mármol Contreras & Poonam Shah & Hector Gutierrez & Thomas A. Green & Martin B. Ulmschneider & Marcello D’Ascenzo & Clifford Stephan & Guohong Cui & Fabricio H. Monte & Jia Zhou & Fernanda Laezza - 1-27 Multi-country and intersectoral assessment of cluster congruence between pipelines for genomics surveillance of foodborne pathogens
by Verónica Mixão & Miguel Pinto & Holger Brendebach & Daniel Sobral & João Dourado Santos & Nicolas Radomski & Anne Sophie Majgaard Uldall & Arkadiusz Bomba & Michael Pietsch & Andrea Bucciacchio & Andrea Ruvo & Pierluigi Castelli & Ewelina Iwan & Sandra Simon & Claudia E. Coipan & Jörg Linde & Liljana Petrovska & Rolf Sommer Kaas & Katrine Grimstrup Joensen & Sofie Holtsmark Nielsen & Kristoffer Kiil & Karin Lagesen & Adriano Pasquale & João Paulo Gomes & Carlus Deneke & Simon H. Tausch & Vítor Borges - 1-28 Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies
by Yan-Ruide Li & Ying Fang & Siyue Niu & Yichen Zhu & Yuning Chen & Zibai Lyu & Enbo Zhu & Yanxin Tian & Jie Huang & Valerie Rezek & Scott Kitchen & Tzung Hsiai & Jin J. Zhou & Pin Wang & Wanxing Chai-Ho & Sunmin Park & Christopher S. Seet & Caspian Oliai & Lili Yang - 1-29 METTL9 sustains vertebrate neural development primarily via non-catalytic functions
by Azzurra Codino & Luca Spagnoletti & Claudia Olobardi & Alessandro Cuomo & Helena Santos-Rosa & Martina Palomba & Natasha Margaroli & Stefania Girotto & Rita Scarpelli & Shi-Lu Luan & Eleonora Crocco & Paolo Bianchini & Andrew J. Bannister & Stefano Gustincich & Tony Kouzarides & Riccardo Rizzo & Isaia Barbieri & Federico Cremisi & Robert Vignali & Luca Pandolfini - 1-30 An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis
by Omar El Bounkari & Chunfang Zan & Bishan Yang & Simon Ebert & Jonas Wagner & Elina Bugar & Naomi Kramer & Priscila Bourilhon & Christos Kontos & Marlies Zarwel & Dzmitry Sinitski & Jelena Milic & Yvonne Jansen & Wolfgang E. Kempf & Nadja Sachs & Lars Maegdefessel & Hao Ji & Ozgun Gokce & Fabien Riols & Mark Haid & Simona Gerra & Adrian Hoffmann & Markus Brandhofer & Maida Avdic & Richard Bucala & Remco T. A. Megens & Nienke Willemsen & Denise Messerer & Christian Schulz & Alexander Bartelt & Tobias Harm & Dominik Rath & Yvonne Döring & Meinrad Gawaz & Christian Weber & Aphrodite Kapurniotu & Jürgen Bernhagen - 1-30 A decision-space model explains context-specific decision-making
by Dirk W. Beck & Cory N. Heaton & Luis D. Davila & Lara I. Rakocevic & Sabrina M. Drammis & Danil Tyulmankov & Atanu Giri & Shreeya Umashankar Beck & Qingyang Zhang & Michael Pokojovy & Kenichiro Negishi & Alexis A. Salcido & Neftali F. Reyes & Andrea Y. Macias & Serina A. Batson & Paulina Vara & Raquel J. Ibáñez Alcalá & Safa B. Hossain & Graham L. Waller & Laura E. O’Dell & Travis M. Moschak & Ki A. Goosens & Alexander Friedman - 1-30 Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism
by Bartlomiej Taciak & Maciej Bialasek & Malgorzata Kubiak & Ilona Marszalek & Malgorzata Gorczak & Olha Osadchuk & Daria Kurpiel & Damian Strzemecki & Karolina Barwik & Marcin Skorzynski & Julia Nowakowska & Waldemar Lipiński & Łukasz Kiraga & Jan Brancewicz & Robert Klopfleisch & Łukasz Krzemiński & Emilia Gorka & Anna Smolarska & Irena Padzinska-Pruszynska & Małgorzata Siemińska & Jakub Guzek & Jan Kutner & Marlena Kisiala & Krzysztof Wozniak & Giacomo Parisi & Roberta Piacentini & Luca Cassetta & Lesley M. Forrester & Lubomir Bodnar & Tobias Weiss & Alberto Boffi & Paulina Kucharzewska & Tomasz P. Rygiel & Magdalena Krol - 1-31 Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation
by André Gollowitzer & Helmut Pein & Zhigang Rao & Lorenz Waltl & Leonhard Bereuter & Konstantin Loeser & Tobias Meyer & Vajiheh Jafari & Finja Witt & René Winkler & Fengting Su & Silke Große & Maria Thürmer & Julia Grander & Madlen Hotze & Sönke Harder & Lilia Espada & Alexander Magnutzki & Ronald Gstir & Christina Weinigel & Silke Rummler & Günther Bonn & Johanna Pachmayr & Maria Ermolaeva & Takeshi Harayama & Hartmut Schlüter & Christian Kosan & Regine Heller & Kathrin Thedieck & Michael Schmitt & Takao Shimizu & Jürgen Popp & Hideo Shindou & Marcel Kwiatkowski & Andreas Koeberle - 1-33 Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans
by Xia Wu & Dan Xiong & Rong Liu & Xingqiang Lai & Yuhan Tian & Ziying Xie & Li Chen & Lanqi Hu & Jingjing Duan & Xinyu Gao & Xian Zeng & Wei Dong & Ting Xu & Fang Fu & Xin Yang & Xinlai Cheng & Dariusz Plewczynski & Minji Kim & Wenjun Xin & Tianyun Wang & Andy Peng Xiang & Zhonghui Tang - 1-33 Machine learning in point-of-care testing: innovations, challenges, and opportunities
by Gyeo-Re Han & Artem Goncharov & Merve Eryilmaz & Shun Ye & Barath Palanisamy & Rajesh Ghosh & Fabio Lisi & Elliott Rogers & David Guzman & Defne Yigci & Savas Tasoglu & Dino Di Carlo & Keisuke Goda & Rachel A. McKendry & Aydogan Ozcan