Minkowski--Weyl Priors for Models With Parameter Constraints: An Analysis of the BioCycle Study
We propose a general framework for performing full Bayesian analysis under linear inequality parameter constraints. The proposal is motivated by the BioCycle Study, a large cohort study of hormone levels of healthy women where certain well-established linear inequality constraints on the log-hormone levels should be accounted for in the statistical inferential procedure. Based on the Minkowski--Weyl decomposition of polyhedral regions, we propose a class of priors that are fully supported on the parameter space with linear inequality constraints, and we fit a Bayesian linear mixed model to the BioCycle data using such a prior. We observe positive associations between estrogen and progesterone levels and F 2 -isoprostanes, a marker for oxidative stress. These findings are of particular interest to reproductive epidemiologists.
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Volume (Year): 107 (2012)
Issue (Month): 500 (December)
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