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Estimating Regression Parameters in an Extended Proportional Odds Model


  • Ying Qing Chen
  • Nan Hu
  • Su-Chun Cheng
  • Philippa Musoke
  • Lue Ping Zhao


The proportional odds model may serve as a useful alternative to the Cox proportional hazards model to study association between covariates and their survival functions in medical studies. In this article, we study an extended proportional odds model that incorporates the so-called “external” time-varying covariates. In the extended model, regression parameters have a direct interpretation of comparing survival functions, without specifying the baseline survival odds function. Semiparametric and maximum likelihood estimation procedures are proposed to estimate the extended model. Our methods are demonstrated by Monte Carlo simulations, and applied to a landmark randomized clinical trial of a short-course nevirapine (NVP) for mother-to-child transmission (MTCT) of human immunodeficiency virus type-1 (HIV-1). Additional application includes an analysis of the well-known Veterans Administration (VA) lung cancer trial.

Suggested Citation

  • Ying Qing Chen & Nan Hu & Su-Chun Cheng & Philippa Musoke & Lue Ping Zhao, 2012. "Estimating Regression Parameters in an Extended Proportional Odds Model," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(497), pages 318-330, March.
  • Handle: RePEc:taf:jnlasa:v:107:y:2012:i:497:p:318-330
    DOI: 10.1080/01621459.2012.656021

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    Cited by:

    1. Yuan Mengdie & Diao Guoqing, 2014. "Semiparametric Odds Rate Model for Modeling Short-Term and Long-Term Effects with Application to a Breast Cancer Genetic Study," The International Journal of Biostatistics, De Gruyter, vol. 10(2), pages 1-19, November.

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