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Non-Price-Related Determinants of Value and Access for Novel Non-small Cell Lung Cancer Treatments: A Cross-Country Review of HTA Decision Making

Author

Listed:
  • Jason Gordon

    (Health Economics and Outcomes Research Ltd)

  • Angela Stainthorpe

    (Health Economics and Outcomes Research Ltd)

  • Beverley Jones

    (Health Economics and Outcomes Research Ltd)

  • Ian Jacob

    (Health Economics and Outcomes Research Ltd)

  • Nadine Hertel

    (Bristol Myers Squibb, WW HEOR)

  • Jose Diaz

    (Bristol Myers Squibb, WW HEOR)

  • Yong Yuan

    (Bristol Myers Squibb, WW HEOR)

  • John Borrill

    (Bristol Myers Squibb, WW HEOR)

Abstract

Introduction Access and funding for newly approved treatments for non-small cell lung cancer (NSCLC) are often dependent on Health Technology Assessment (HTA) involving cost-effectiveness analysis. Whilst methods used by HTA agencies share many similarities, final decisions may differ. This may be the result, not just of price considerations, but also of variation in value judgements by different agencies. The aim of this study was to review international HTA evaluations to identify determinants of value and access for NSCLC treatments. Methods A targeted review and analysis was undertaken of published HTAs for NSCLC across HTA agencies in six countries (Australia, Canada, England, France, Ireland and Scotland). Analysis of extracted data consisted of three stages: descriptive analysis, bivariate analysis and multivariable analysis. Results The analysis included 163 HTAs that assessed oncological treatments for NSCLC from 2003 to 2019. The majority of HTA decisions (67.5%) were positive. However, some evidence of heterogeneity in HTA decisions and the factors informing them were identified. The most influential factors included in the multivariate model related to the HTA agency conducting the appraisal, the year of market authorisation, treatment type and the line of treatment. Conclusion Heterogenous decision-making frameworks can present a challenge to developing HTA submissions. This research contributes to understanding decision-making factors and why countries make different decisions.

Suggested Citation

  • Jason Gordon & Angela Stainthorpe & Beverley Jones & Ian Jacob & Nadine Hertel & Jose Diaz & Yong Yuan & John Borrill, 2021. "Non-Price-Related Determinants of Value and Access for Novel Non-small Cell Lung Cancer Treatments: A Cross-Country Review of HTA Decision Making," PharmacoEconomics - Open, Springer, vol. 5(4), pages 701-713, December.
    • Handle: RePEc:spr:pharmo:v:5:y:2021:i:4:d:10.1007_s41669-021-00279-2
    DOI: 10.1007/s41669-021-00279-2
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    References listed on IDEAS

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    1. Cerri, Karin H & Knapp, Martin & Fernandez, Jose-Luis, 2014. "Decision making by NICE: examining the influences of evidence, process and context – CORRIGENDUM," Health Economics, Policy and Law, Cambridge University Press, vol. 9(4), pages 435-435, October.
    2. Cerri, Karin H. & Knapp, Martin & Fernandez, Jose-Luis, 2014. "Decision making by NICE: examining the influences of evidence, process and context," Health Economics, Policy and Law, Cambridge University Press, vol. 9(2), pages 119-141, April.
    3. Maynou, Laia & Cairns, John, 2019. "What is driving HTA decision-making? Evidence from cancer drug reimbursement decisions from 6 European countries," Health Policy, Elsevier, vol. 123(2), pages 130-139.
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    1. Fontrier, Anna-Maria & Kamphuis, Bregtje W. & Kanavos, Panos, 2023. "How can health technology assessment be improved to optimise access to medicines? Results from a Delphi study in Europe," LSE Research Online Documents on Economics 120537, London School of Economics and Political Science, LSE Library.

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