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An Investigation of the Overlap Between the ICECAP-A and Five Preference-Based Health-Related Quality of Life Instruments


  • Lidia Engel

    (Simon Fraser University
    Vancouver Coastal Health Research Institute)

  • Duncan Mortimer

    (Monash University)

  • Stirling Bryan

    (Vancouver Coastal Health Research Institute
    University of British Columbia)

  • Scott A. Lear

    (Simon Fraser University
    Providence Health Care)

  • David G. T. Whitehurst

    () (Simon Fraser University
    Vancouver Coastal Health Research Institute
    International Collaboration on Repair Discoveries, University of British Columbia)


Abstract Background The ICEpop CAPability measure for Adults (ICECAP-A) is a measure of capability wellbeing developed for use in economic evaluations. It was designed to overcome perceived limitations associated with existing preference-based instruments, where the explicit focus on health-related aspects of quality of life may result in the failure to capture fully the broader benefits of interventions and treatments that go beyond health. The aim of this study was to investigate the extent to which preference-based health-related quality of life (HRQoL) instruments are able to capture aspects of capability wellbeing, as measured by the ICECAP-A. Methods Using data from the Multi Instrument Comparison project, pairwise exploratory factor analyses were conducted to compare the ICECAP-A with five preference-based HRQoL instruments [15D, Assessment of Quality of Life 8-dimension (AQoL-8D), EQ-5D-5L, Health Utilities Index Mark 3 (HUI-3), and SF-6D]. Results Data from 6756 individuals were used in the analyses. The ICECAP-A provides information above that garnered from most commonly used preference-based HRQoL instruments. The exception was the AQoL-8D; more common factors were identified between the ICECAP-A and AQoL-8D compared with the other pairwise analyses. Conclusion Further investigations are needed to explore the extent and potential implications of ‘double counting’ when applying the ICECAP-A alongside health-related preference-based instruments.

Suggested Citation

  • Lidia Engel & Duncan Mortimer & Stirling Bryan & Scott A. Lear & David G. T. Whitehurst, 2017. "An Investigation of the Overlap Between the ICECAP-A and Five Preference-Based Health-Related Quality of Life Instruments," PharmacoEconomics, Springer, vol. 35(7), pages 741-753, July.
  • Handle: RePEc:spr:pharme:v:35:y:2017:i:7:d:10.1007_s40273-017-0491-7
    DOI: 10.1007/s40273-017-0491-7

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    References listed on IDEAS

    1. Richard Cookson, 2005. "QALYs and capabilities: a response to Anand," Health Economics, John Wiley & Sons, Ltd., vol. 14(12), pages 1287-1289.
    2. Terry N. Flynn & Elisabeth Huynh & Tim J. Peters & Hareth Al‐Janabi & Sam Clemens & Alison Moody & Joanna Coast, 2015. "Scoring the Icecap‐a Capability Instrument. Estimation of a UK General Population Tariff," Health Economics, John Wiley & Sons, Ltd., vol. 24(3), pages 258-269, March.
    3. Paul Mark Mitchell & Sridhar Venkatapuram & Jeff Richardson & Angelo Iezzi & Joanna Coast, 2017. "Are Quality-Adjusted Life Years a Good Proxy Measure of Individual Capabilities?," PharmacoEconomics, Springer, vol. 35(6), pages 637-646, June.
    4. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
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    Blog mentions

    As found by, the blog aggregator for Economics research:
    1. Thesis Thursday: Lidia Engel
      by Chris Sampson in The Academic Health Economists' Blog on 2017-09-21 11:00:49


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    Cited by:

    1. Engel, Lidia & Bryan, Stirling & Noonan, Vanessa K. & Whitehurst, David G.T., 2018. "Using path analysis to investigate the relationships between standardized instruments that measure health-related quality of life, capability wellbeing and subjective wellbeing: An application in the ," Social Science & Medicine, Elsevier, vol. 213(C), pages 154-164.


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