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Patient Preferences in the Management of Hidradenitis Suppurativa: Results of a Multinational Discrete Choice Experiment in Europe

Author

Listed:
  • Damon Willems

    (Maastricht University)

  • Eva-Lotta Hinzpeter

    (Maastricht University)

  • Hessel H. Zee

    (Erasmus University Medical Center)

  • Christopher J. Sayed

    (University of North Carolina at Chapel Hill)

  • John R. Ingram

    (Cardiff University, University Hospital of Wales)

  • Charlotte Beaudart

    (Maastricht University
    University of Liege)

  • Silvia M. A. A. Evers

    (Maastricht University
    Netherlands Institute of Mental Health and Addiction)

  • Mickael Hiligsmann

    (Maastricht University)

Abstract

Background and Objective Hidradenitis suppurativa is a chronic inflammatory skin disease that can lead to a substantial reduction in quality of life. Recent studies revealed high levels of unmet care needs of patients with hidradenitis suppurativa, but their preferences in treatment decision making have scarcely been investigated. This study aimed to reveal which treatment attributes adult patients with HS in Europe consider most important in treatment decision-making. Methods A discrete choice experiment was conducted with adult patients with hidradenitis suppurativa in Europe to reveal which treatment attributes are most important when making treatment decisions. Participants were presented with 15 sets of two treatment options and asked for each to choose the treatment they preferred. The treatments were characterized by six attributes informed by a prior literature review and qualitative research: effectiveness, pain reduction, duration of treatment benefit, risk of mild adverse event, risk of serious infection, and mode of administration. A random parameter logit model was used to estimate patients’ preferences with additional subgroup and latent class models used to explore any differences in preferences across patient groups. Results Two hundred and nineteen adult patients with hidradenitis suppurativa were included in the analysis (90% women, mean age 38 years). For all six treatment attributes, significant differences were observed between levels. Given the range of levels of each attribute, the most important treatment attributes were effectiveness (47.9%), followed by pain reduction (17.3%), annual risk of a mild adverse event (14.4%), annual risk of a serious infection (10.3%), mode of administration (5.3%), and duration of treatment benefit (4.8%). Higher levels of effectiveness, namely a 75% or 100% reduction in the abscess and inflammatory nodule count, were preferred over levels of effectiveness primarily investigated in randomized clinical trials of hidradenitis suppurativa (a 50% reduction). Results were largely consistent across subgroups and three latent class groups were identified. Conclusions This study revealed the most important treatment characteristics for patients with hidradenitis suppurativa that can help inform joint patient-physician decision making in the management of hidradenitis suppurativa. Designing future hidradenitis suppurativa treatments according to stated preferences, namely, to offer higher levels of effectiveness and pain improvement without higher risks of adverse events, may increase patients’ treatment concordance and lead to improved disease management outcomes.

Suggested Citation

  • Damon Willems & Eva-Lotta Hinzpeter & Hessel H. Zee & Christopher J. Sayed & John R. Ingram & Charlotte Beaudart & Silvia M. A. A. Evers & Mickael Hiligsmann, 2023. "Patient Preferences in the Management of Hidradenitis Suppurativa: Results of a Multinational Discrete Choice Experiment in Europe," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 16(2), pages 153-164, March.
    • Handle: RePEc:spr:patien:v:16:y:2023:i:2:d:10.1007_s40271-022-00614-7
    DOI: 10.1007/s40271-022-00614-7
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    References listed on IDEAS

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    1. Bethan Copsey & James Buchanan & Raymond Fitzpatrick & Sarah E. Lamb & Susan J. Dutton & Jonathan A. Cook, 2019. "Duration of Treatment Effect Should Be Considered in the Design and Interpretation of Clinical Trials: Results of a Discrete Choice Experiment," Medical Decision Making, , vol. 39(4), pages 461-473, May.
    2. Caroline Vass & Dan Rigby & Katherine Payne, 2017. "The Role of Qualitative Research Methods in Discrete Choice Experiments," Medical Decision Making, , vol. 37(3), pages 298-313, April.
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