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Bayesian Assessment of Sample Size for Clinical Trials of Cost-Effectiveness

Author

Listed:
  • Anthony O’Hagan

    (University of Sheffield, United Kingdom)

  • John W. Stevens

    (AstraZeneca R&!D Charnwood, United Kingdom)

Abstract

The authors present an analysis of the choice of sample sizes for demonstrating cost-effectiveness of a new treatment or procedure, when data on both cost and efficacy will be collected in a clinical trial. The Bayesian approach to statistics is employed, as well as a novel Bayesian criterion that provides insight into the sample size problem and offers a very flexible formulation.

Suggested Citation

  • Anthony O’Hagan & John W. Stevens, 2001. "Bayesian Assessment of Sample Size for Clinical Trials of Cost-Effectiveness," Medical Decision Making, , vol. 21(3), pages 219-230, May.
    • Handle: RePEc:sae:medema:v:21:y:2001:i:3:p:219-230
    DOI: 10.1177/0272989X0102100307
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    References listed on IDEAS

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    1. Briggs, Andrew & Tambour, Magnus, 1998. "The design and analysis of stochastic cost-effectiveness studies for the evaluation of health care interventions," SSE/EFI Working Paper Series in Economics and Finance 234, Stockholm School of Economics.
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    Citations

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    Cited by:

    1. Alan Brennan & Samer A. Kharroubi, 2007. "Expected value of sample information for Weibull survival data," Health Economics, John Wiley & Sons, Ltd., vol. 16(11), pages 1205-1225, November.
    2. Andrew R. Willan & Matthew E. Kowgier, 2008. "Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate," Health Economics, John Wiley & Sons, Ltd., vol. 17(7), pages 777-791, July.
    3. C. Armero & G. García‐Donato & A. López‐Quílez, 2010. "Bayesian methods in cost–effectiveness studies: objectivity, computation and other relevant aspects," Health Economics, John Wiley & Sons, Ltd., vol. 19(6), pages 629-643, June.
    4. Miguel A. Negrín & Francisco J. Vázquez‐Polo, 2006. "Bayesian cost‐effectiveness analysis with two measures of effectiveness: the cost‐effectiveness acceptability plane," Health Economics, John Wiley & Sons, Ltd., vol. 15(4), pages 363-372, April.
    5. Simon Eckermann & Andrew R. Willan, 2009. "Globally optimal trial design for local decision making," Health Economics, John Wiley & Sons, Ltd., vol. 18(2), pages 203-216, February.
    6. Pierpaolo Brutti & Fulvio Santis & Stefania Gubbiotti, 2014. "Bayesian-frequentist sample size determination: a game of two priors," METRON, Springer;Sapienza Università di Roma, vol. 72(2), pages 133-151, August.
    7. Theodoros Mantopoulos & Paul M. Mitchell & Nicky J. Welton & Richard McManus & Lazaros Andronis, 2016. "Choice of statistical model for cost-effectiveness analysis and covariate adjustment: empirical application of prominent models and assessment of their results," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(8), pages 927-938, November.
    8. F. J. Vázquez‐Polo & M. A. Negrín Hernández & B. González López‐Valcárcel, 2005. "Using covariates to reduce uncertainty in the economic evaluation of clinical trial data," Health Economics, John Wiley & Sons, Ltd., vol. 14(6), pages 545-557, June.
    9. A. Gafni & S. D. Walter & S. Birch & P. Sendi, 2008. "An opportunity cost approach to sample size calculation in cost‐effectiveness analysis," Health Economics, John Wiley & Sons, Ltd., vol. 17(1), pages 99-107, January.
    10. Daniel P Beavers & James D Stamey, 2018. "Bayesian sample size determination for cost-effectiveness studies with censored data," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-16, January.
    11. Fulvio De Santis & Stefania Gubbiotti, 2021. "On the predictive performance of a non-optimal action in hypothesis testing," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 30(2), pages 689-709, June.
    12. Alan Brennan & Samer A. Kharroubi, 2007. "Expected value of sample information for Weibull survival data," Health Economics, John Wiley & Sons, Ltd., vol. 16(11), pages 1205-1225.
    13. Henry Glick, 2011. "Sample Size and Power for Cost-Effectiveness Analysis (Part 1)," PharmacoEconomics, Springer, vol. 29(3), pages 189-198, March.
    14. Andrew Willan, 2011. "Sample Size Determination for Cost-Effectiveness Trials," PharmacoEconomics, Springer, vol. 29(11), pages 933-949, November.
    15. Thompson, Nathanael M. & Brorsen, B. Wade & DeVuyst, Eric A. & Lusk, Jayson L., 2016. "Random Sampling of Beef Cattle for Genetic Testing: Optimal Sample Size Determination," 2016 Annual Meeting, February 6-9, 2016, San Antonio, Texas 229195, Southern Agricultural Economics Association.
    16. P. Brutti & F. Santis & S. Gubbiotti, 2013. "Robust Bayesian monitoring of sequential trials," METRON, Springer;Sapienza Università di Roma, vol. 71(1), pages 81-95, June.

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