IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0276261.html
   My bibliography  Save this article

The PROVENT-C19 registry: A study protocol for international multicenter SIAARTI registry on the use of prone positioning in mechanically ventilated patients with COVID-19 ARDS

Author

Listed:
  • Silvia De Rosa
  • Nicolò Sella
  • Emanuele Rezoagli
  • Giulia Lorenzoni
  • Dario Gregori
  • Giacomo Bellani
  • Giuseppe Foti
  • Tommaso Pettenuzzo
  • Fabio Baratto
  • Giorgio Fullin
  • Francesco Papaccio
  • Mario Peta
  • Daniele Poole
  • Fabio Toffoletto
  • Salvatore Maurizio Maggiore
  • Paolo Navalesi
  • The SIAARTI Study Group

Abstract

Background: The worldwide use of prone position (PP) for invasively ventilated patients with COVID-19 is progressively increasing from the first pandemic wave in everyday clinical practice. Among the suggested treatments for the management of ARDS patients, PP was recommended in the Surviving Sepsis Campaign COVID-19 guidelines as an adjuvant therapy for improving ventilation. In patients with severe classical ARDS, some authors reported that early application of prolonged PP sessions significantly decreases 28-day and 90-day mortality. Methods and analysis: Since January 2021, the COVID19 Veneto ICU Network research group has developed and implemented nationally and internationally the “PROVENT-C19 Registry”, endorsed by the Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care…’(SIAARTI). The PROVENT-C19 Registry wishes to describe 1. The real clinical practice on the use of PP in COVID-19 patients during the pandemic at a National and International level; and 2. Potential baseline and clinical characteristics that identify subpopulations of invasively ventilated patients with COVID-19 that may improve daily from PP therapy. This web-based registry will provide relevant information on how the database research tools may improve our daily clinical practice. Conclusions: This multicenter, prospective registry is the first to identify and characterize the role of PP on clinical outcome in COVID-19 patients. In recent years, data emerging from large registries have been increasingly used to provide real-world evidence on the effectiveness, quality, and safety of a clinical intervention. Indeed observation-based registries could be effective tools aimed at identifying specific clusters of patients within a large study population with widely heterogeneous clinical characteristics. Trial registration: The registry was registered (ClinicalTrial.Gov Trials Register NCT04905875) on May 28,2021.

Suggested Citation

  • Silvia De Rosa & Nicolò Sella & Emanuele Rezoagli & Giulia Lorenzoni & Dario Gregori & Giacomo Bellani & Giuseppe Foti & Tommaso Pettenuzzo & Fabio Baratto & Giorgio Fullin & Francesco Papaccio & Mari, 2022. "The PROVENT-C19 registry: A study protocol for international multicenter SIAARTI registry on the use of prone positioning in mechanically ventilated patients with COVID-19 ARDS," PLOS ONE, Public Library of Science, vol. 17(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0276261
    DOI: 10.1371/journal.pone.0276261
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276261
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0276261&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0276261?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Chen, Ming-Hui & Ibrahim, Joseph G. & Sinha, Debajyoti, 2004. "A new joint model for longitudinal and survival data with a cure fraction," Journal of Multivariate Analysis, Elsevier, vol. 91(1), pages 18-34, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Song Zhang & Peter Müller & Kim-Anh Do, 2010. "A Bayesian Semiparametric Survival Model with Longitudinal Markers," Biometrics, The International Biometric Society, vol. 66(2), pages 435-443, June.
    2. Hongtu Zhu & Joseph G. Ibrahim & Yueh-Yun Chi & Niansheng Tang, 2012. "Bayesian Influence Measures for Joint Models for Longitudinal and Survival Data," Biometrics, The International Biometric Society, vol. 68(3), pages 954-964, September.
    3. Sik-Yum Lee & Ye-Mao Xia, 2008. "A Robust Bayesian Approach for Structural Equation Models with Missing Data," Psychometrika, Springer;The Psychometric Society, vol. 73(3), pages 343-364, September.
    4. Taban Baghfalaki & Mojtaba Ganjali & Geert Verbeke, 2017. "A shared parameter model of longitudinal measurements and survival time with heterogeneous random-effects distribution," Journal of Applied Statistics, Taylor & Francis Journals, vol. 44(15), pages 2813-2836, November.
    5. Shuangge Ma, 2011. "Additive risk model for current status data with a cured subgroup," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 63(1), pages 117-134, February.
    6. Philippe Lambert & Vincent Bremhorst, 2020. "Inclusion of time‐varying covariates in cure survival models with an application in fertility studies," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 183(1), pages 333-354, January.
    7. Jiawei Xu & Matthew A. Psioda & Joseph G. Ibrahim, 2023. "Bayesian Design of Clinical Trials Using Joint Cure Rate Models for Longitudinal and Time-to-Event Data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(1), pages 213-233, January.
    8. Shahedul A. Khan & Nyla Basharat, 2022. "Accelerated failure time models for recurrent event data analysis and joint modeling," Computational Statistics, Springer, vol. 37(4), pages 1569-1597, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0276261. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.