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Clinical epidemiology and outcomes of community acquired infection and sepsis among hospitalized patients in a resource limited setting in Northeast Thailand: A prospective observational study (Ubon-sepsis)

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  • Viriya Hantrakun
  • Ranjani Somayaji
  • Prapit Teparrukkul
  • Chaiyaporn Boonsri
  • Kristina Rudd
  • Nicholas P J Day
  • T Eoin West
  • Direk Limmathurotsakul

Abstract

Infection and sepsis are leading causes of death worldwide but the epidemiology and outcomes are not well understood in resource-limited settings. We conducted a four-year prospective observational study from March 2013 to February 2017 to examine the clinical epidemiology and outcomes of adults admitted with community-acquired infection in a resource-limited tertiary-care hospital in Ubon Ratchathani province, Northeast Thailand. Hospitalized patients with infection and accompanying systemic manifestations of infection within 24 hours of admission were enrolled. Subjects were classified as having sepsis if they had a modified sequential organ failure assessment (SOFA) score ≥2 at enrollment. This study was registered with ClinicalTrials.gov, number NCT02217592. A total of 4,989 patients were analyzed. Of the cohort, 2,659 (53%) were male and the median age was 57 years (range 18–101). Of these, 1,173 (24%) patients presented primarily to the study hospital, 3,524 (71%) were transferred from 25 district hospitals or 8 smaller hospitals in the province, and 292 (6%) were transferred from one of 30 hospitals in other provinces. Three thousand seven hundred and sixteen (74%) patients were classified as having sepsis. Patients with sepsis had an older age distribution and a greater prevalence of comorbidities compared to patients without sepsis. Twenty eight-day mortality was 21% (765/3,716) in sepsis and 4% (54/1,273) in non-sepsis patients (p

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  • Viriya Hantrakun & Ranjani Somayaji & Prapit Teparrukkul & Chaiyaporn Boonsri & Kristina Rudd & Nicholas P J Day & T Eoin West & Direk Limmathurotsakul, 2018. "Clinical epidemiology and outcomes of community acquired infection and sepsis among hospitalized patients in a resource limited setting in Northeast Thailand: A prospective observational study (Ubon-s," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0204509
    DOI: 10.1371/journal.pone.0204509
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    1. World Bank, 2017. "World Development Indicators 2017," World Bank Publications - Books, The World Bank Group, number 26447, August.
    2. World Bank, 2013. "World Development Indicators 2013," World Bank Publications - Books, The World Bank Group, number 13191, August.
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    1. Kasturi Selvam & Thanasree Ganapathy & Mohamad Ahmad Najib & Muhammad Fazli Khalid & Nor Azlina Abdullah & Azian Harun & Wan Mohd Zahiruddin Wan Mohammad & Ismail Aziah, 2022. "Burden and Risk Factors of Melioidosis in Southeast Asia: A Scoping Review," IJERPH, MDPI, vol. 19(23), pages 1-16, November.

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