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Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis

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  • Adolfo Maria Tambella
  • Anna Rita Attili
  • Gilles Dupré
  • Andrea Cantalamessa
  • Stefano Martin
  • Vincenzo Cuteri
  • Sabrina Marcazzan
  • Massimo Del Fabbro

Abstract

The objective of the study was to review current literature to determine whether the topical application of platelet-rich plasma (PRP) promotes healing in experimentally-induced full-thickness skin wounds in animals. The hypothesis was that the adjunct of PRP has a positive effect on wound healing. An electronic search was carried out on the following databases: Web of Science, Cochrane Library, PubMed, Research Gate, Cochrane Wounds Group, Veterinary Information Network. No publication date nor language restrictions were applied. Randomised and not randomised controlled clinical trials comparing PRP with placebo or with other treatments were included. The reduction of open wound area in PRP-treated (test) wounds compared to control wounds was the primary outcome. Secondary outcomes were healing time and number of healed cases in test group compared to control. The following effect sizes were calculated: the Hedges’ g for continuous variables; the odds ratio for binary data. Eighteen controlled clinical trials were included in the qualitative and quantitative synthesis, with a total of 661 wounds. All studies were published in the period 2007–2016. Eight studies were carried out on rodent/lagomorph mammals and 10 on non-rodent/lagomorph mammals. In all included studies, control wounds underwent placebo or were left untreated. The PRP group showed a better healing performance than the control group in each outcome. The effect size was statistically significant considering the primary outcome and the overall aggregation of the three outcomes. The effect size, although in favour of the treatment with PRP, was not significant considering the healing time and the number of healings. The overall heterogeneity was mild or moderate. Five studies reported a high risk of selection bias. The publication bias was always mild or absent. The results support the hypothesis of the positive effects of the PRP when compared to control groups in the treatment of experimentally-induced full-thickness skin wounds in animals. PRP can therefore be considered an effective adjunctive therapy in stimulating second intention healing of acute wounds in healthy animals.

Suggested Citation

  • Adolfo Maria Tambella & Anna Rita Attili & Gilles Dupré & Andrea Cantalamessa & Stefano Martin & Vincenzo Cuteri & Sabrina Marcazzan & Massimo Del Fabbro, 2018. "Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-26, January.
    • Handle: RePEc:plo:pone00:0191093
    DOI: 10.1371/journal.pone.0191093
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    References listed on IDEAS

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    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    3. Lenard I Lesser & Cara B Ebbeling & Merrill Goozner & David Wypij & David S Ludwig, 2007. "Relationship between Funding Source and Conclusion among Nutrition-Related Scientific Articles," PLOS Medicine, Public Library of Science, vol. 4(1), pages 1-6, January.
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    1. A Marchegiani & A Spaterna & A Palumbo Piccionello & M Meligrana & A Fruganti & AM Tambella, 2020. "Fluorescence biomodulation in the management of acute traumatic wounds in two aged dogs," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 65(5), pages 215-220.

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