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SF-6D utility values for the better- and worse-seeing eye for health states based on the Snellen equivalent in patients with age-related macular degeneration

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  • Martijn S Visser
  • Sankha Amarakoon
  • Tom Missotten
  • Reinier Timman
  • Jan J Busschbach

Abstract

Objective: Economic evaluations in wet age-related macular degeneration (ARMD) is hampered as often utility values for solely one eye are used, mostly the better-seeing eye (BSE). Moreover, frequently chosen methods rely on patient values and/or disease specific measures, while economic evaluations prefer generic quality of life (QoL) measures based on societal preferences. The generic QoL utility instrument EQ-5D has shown to be insensitive for differences in visual acuity. The aim of this study was therefore to provide societal utility values, using the generic SF-6D, for health states acknowledging both BSE and worse-seeing eye (WSE). Methods: SF-6D utility values of 191 ARMD patients (≥65 years) with 153 follow-up measures at 1 year were used to fill health states defined by the combination of BSE and WSE using Snellen equivalents; no visual loss (≥20/40), mild-moderate ( 20/200) and severe (≤20/200). Results: QoL utilities were estimated for the SF-6D, ranging from 0.740 for ARMD patients without visual loss to 0.684 for patients with a combination of mild-moderate visual loss in their BSE and severe visual loss in their WSE. Conclusion: Societal utility values are provided for ARMD patients using the generic QoL instrument SF-6D for visual acuity health states based on both BSE and WSE. The range of the values is smaller than previous elicited utilities with the disease-specific VisQoL. Besides, the utility values are placed on a more realistic position on the utility scale, and SF-6D utility values avoid the problem associated with the interpretation of disease-specific utility values.

Suggested Citation

  • Martijn S Visser & Sankha Amarakoon & Tom Missotten & Reinier Timman & Jan J Busschbach, 2017. "SF-6D utility values for the better- and worse-seeing eye for health states based on the Snellen equivalent in patients with age-related macular degeneration," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-9, February.
  • Handle: RePEc:plo:pone00:0169816
    DOI: 10.1371/journal.pone.0169816
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    References listed on IDEAS

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    1. Robert P Finger & Eva Fenwick & Christoph W Hirneiss & Arthur Hsueh & Robyn H Guymer & Ecosse L Lamoureux & Jill E Keeffe, 2013. "Visual Impairment as a Function of Visual Acuity in Both Eyes and Its Impact on Patient Reported Preferences," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-6, December.
    2. Brazier, John & Roberts, Jennifer & Deverill, Mark, 2002. "The estimation of a preference-based measure of health from the SF-36," Journal of Health Economics, Elsevier, vol. 21(2), pages 271-292, March.
    3. John Brazier & Aki Tsuchiya, 2010. "Preference‐based condition‐specific measures of health: what happens to cross programme comparability?," Health Economics, John Wiley & Sons, Ltd., vol. 19(2), pages 125-129, February.
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