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Empirical fitness landscapes reveal accessible evolutionary paths

Author

Listed:
  • Frank J. Poelwijk

    (FOM Institute AMOLF)

  • Daniel J. Kiviet

    (FOM Institute AMOLF)

  • Daniel M. Weinreich

    (Harvard University
    Brown University)

  • Sander J. Tans

    (FOM Institute AMOLF)

Abstract

Missing links recreated Despite the plethora of modern genetic tools, something that is little changed since Darwin's time is our reliance on evolutionary outcomes to unravel the process of evolution. The lack of evolutionary intermediates leaves the door ajar for the proponents of intelligent design. But a new technique could help fill the gaps. It involves the construction of evolutionary intermediates in the lab, and the search for viable paths between them. The resulting 'fitness landscapes' map viable routes between accessible evolutionary paths.

Suggested Citation

  • Frank J. Poelwijk & Daniel J. Kiviet & Daniel M. Weinreich & Sander J. Tans, 2007. "Empirical fitness landscapes reveal accessible evolutionary paths," Nature, Nature, vol. 445(7126), pages 383-386, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7126:d:10.1038_nature05451
    DOI: 10.1038/nature05451
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    Cited by:

    1. Beerenwinkel Niko & Knupfer Patrick & Tresch Achim, 2011. "Learning Monotonic Genotype-Phenotype Maps," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 10(1), pages 1-27, January.
    2. Gilpin, William & Feldman, Marcus W., 2019. "Cryptic selection forces and dynamic heritability in generalized phenotypic evolution," Theoretical Population Biology, Elsevier, vol. 125(C), pages 20-29.
    3. Krishnendu Chatterjee & Andreas Pavlogiannis & Ben Adlam & Martin A Nowak, 2014. "The Time Scale of Evolutionary Innovation," PLOS Computational Biology, Public Library of Science, vol. 10(9), pages 1-7, September.
    4. Alicia Sanchez-Gorostiaga & Djordje Bajić & Melisa L Osborne & Juan F Poyatos & Alvaro Sanchez, 2019. "High-order interactions distort the functional landscape of microbial consortia," PLOS Biology, Public Library of Science, vol. 17(12), pages 1-34, December.
    5. Manhart, Michael & Haldane, Allan & Morozov, Alexandre V., 2012. "A universal scaling law determines time reversibility and steady state of substitutions under selection," Theoretical Population Biology, Elsevier, vol. 82(1), pages 66-76.
    6. Roger D Kouyos & Gabriel E Leventhal & Trevor Hinkley & Mojgan Haddad & Jeannette M Whitcomb & Christos J Petropoulos & Sebastian Bonhoeffer, 2012. "Exploring the Complexity of the HIV-1 Fitness Landscape," PLOS Genetics, Public Library of Science, vol. 8(3), pages 1-9, March.

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