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HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato

Author

Listed:
  • Ting Sun

    (Zhejiang University)

  • Chaoyi Hu

    (Zhejiang University
    Zhejiang University)

  • Changan Zhu

    (Zhejiang University)

  • Jiaxing Cai

    (Zhejiang University)

  • Guoting Wang

    (Zhejiang University)

  • Xiaojian Xia

    (Zhejiang University)

  • Kai Shi

    (Zhejiang University)

  • Yanhong Zhou

    (Zhejiang University
    Ministry of Agriculture and Rural Affairs of China)

  • Jingquan Yu

    (Zhejiang University
    Ministry of Agriculture and Rural Affairs of China)

  • Christine H. Foyer

    (University of Birmingham)

  • Jie Zhou

    (Zhejiang University)

Abstract

Plants have evolved sophisticated defense systems to protect against herbivory, including the systemic induction of jasmonic acid (JA) synthesis. However, the molecular mechanisms underlying this process remain poorly understood. Here, we report that root-knot nematode (RKN) attack induced a phyB-dependent accumulation of ELONGATED HYPOCOTYL 5 (HY5) in the leaves, which activates the expression of JA biosynthesis genes and HY5 itself in tomato. In addition, the systemic transmission of GLUTAMATE RECEPTOR-LIKE 3.5 (GLR3.5)-dependent electrical signals induced by RKN triggers the physical interaction between CALMODULIN 2 (CaM2) and HY5 to amplify the transcriptional regulation of HY5 and JA synthesis. HY5 functions as a systemic signal that moves from leaves to roots to maintain the electrical signaling from roots to leaves by activating GLR3.5 expression. Together, these results reveal a HY5-dependent systemic signaling cascade that integrates light and electrical signals to activate JA-mediated defense against nematodes in tomato.

Suggested Citation

  • Ting Sun & Chaoyi Hu & Changan Zhu & Jiaxing Cai & Guoting Wang & Xiaojian Xia & Kai Shi & Yanhong Zhou & Jingquan Yu & Christine H. Foyer & Jie Zhou, 2025. "HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63779-3
    DOI: 10.1038/s41467-025-63779-3
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