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Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana

Author

Listed:
  • Minoru Ueda

    (Tohoku University
    Tohoku University)

  • Rina Saito

    (Tohoku University)

  • Yuho Nishizato

    (Tohoku University)

  • Tsumugi Kitajima

    (Tohoku University)

  • Nobuki Kato

    (Tohoku University)

Abstract

(+)-cis-12-oxo-phytodienoic acid (cis-OPDA) is a biosynthetic precursor of the plant hormone (+)−7-iso-Jasmonoyl-L-isoleucine (JA-Ile). It was proposed as an endogenous chemical signal independent of the JA-Ile receptor COI1-JAZ in Arabidopsis thaliana. The bioactive form of cis-OPDA that induces COI1-JAZ-independent gene expression remains unknown. Here we demonstrate that the downstream metabolites of cis-OPDA, especially tetranor-cis-OPDA (tn-cis-OPDA) and 7-iso-4,5-didehydro-JA (4,5-ddh-JA), upregulate the expression of the OPDA marker genes such as ZAT10 and ERF5. These downstream metabolites function independently of the JA-Ile-COI1-JAZ-MYCs canonical jasmonate signaling module, and their electrophilic α, β-unsaturated carbonyl functionalities are essential for their bioactivity. These results raise a possibility that the downstream metabolites of cis-OPDA would function as endogenous chemical signal in A. thaliana.

Suggested Citation

  • Minoru Ueda & Rina Saito & Yuho Nishizato & Tsumugi Kitajima & Nobuki Kato, 2025. "Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61072-x
    DOI: 10.1038/s41467-025-61072-x
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    1. A. Chini & S. Fonseca & G. Fernández & B. Adie & J. M. Chico & O. Lorenzo & G. García-Casado & I. López-Vidriero & F. M. Lozano & M. R. Ponce & J. L. Micol & R. Solano, 2007. "The JAZ family of repressors is the missing link in jasmonate signalling," Nature, Nature, vol. 448(7154), pages 666-671, August.
    2. Bryan Thines & Leron Katsir & Maeli Melotto & Yajie Niu & Ajin Mandaokar & Guanghui Liu & Kinya Nomura & Sheng Yang He & Gregg A. Howe & John Browse, 2007. "JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling," Nature, Nature, vol. 448(7154), pages 661-665, August.
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    1. Ting Sun & Chaoyi Hu & Changan Zhu & Jiaxing Cai & Guoting Wang & Xiaojian Xia & Kai Shi & Yanhong Zhou & Jingquan Yu & Christine H. Foyer & Jie Zhou, 2025. "HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    2. Khansa Mekkaoui & Ranjit Baral & Fiona Smith & Moritz Klein & Ivo Feussner & Bettina Hause, 2025. "Transcriptomics and trans-organellar complementation reveal limited signaling of 12-cis-oxo-phytodienoic acid during early wound response in Arabidopsis," Nature Communications, Nature, vol. 16(1), pages 1-17, December.

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