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Unsupervised learning of temporal regularities in visual cortical populations

Author

Listed:
  • Sorin Pojoga

    (Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas
    Center for Neural Systems Restoration, Houston Methodist Research Institute, Dept. of Neurosurgery)

  • Ariana Andrei

    (Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas
    Center for Neural Systems Restoration, Houston Methodist Research Institute, Dept. of Neurosurgery)

  • Valentin Dragoi

    (Center for Neural Systems Restoration, Houston Methodist Research Institute, Dept. of Neurosurgery
    Neuroengineering Initiative, Rice University, Dept. of Electrical and Computer Engineering
    Brain and Mind Research Institute, Dept. of Physiology and Biophysics, Weill Cornell Medical College)

Abstract

The brain’s ability to extract temporal information from dynamic stimuli in the environment is essential for everyday behavior. To extract temporal statistical regularities, neural circuits must possess the ability to measure, produce, and anticipate sensory events. Here we report that when neural populations in macaque primary visual cortex are triggered to exhibit a periodic response to a repetitive sequence of optogenetic laser flashes, they learn to accurately reproduce the temporal sequence even when light stimulation is turned off. Despite the fact that individual cells had a poor capacity to extract temporal information, the population of neurons reproduced the periodic sequence in a temporally precise manner. The same neural population could learn different frequencies of external stimulation, and the ability to extract temporal information was found in all cortical layers. These results demonstrate a remarkable ability of sensory cortical populations to extract and reproduce complex temporal structure from unsupervised external stimulation even when stimuli are perceptually irrelevant.

Suggested Citation

  • Sorin Pojoga & Ariana Andrei & Valentin Dragoi, 2025. "Unsupervised learning of temporal regularities in visual cortical populations," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60731-3
    DOI: 10.1038/s41467-025-60731-3
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    References listed on IDEAS

    as
    1. Diego A. Gutnisky & Valentin Dragoi, 2008. "Adaptive coding of visual information in neural populations," Nature, Nature, vol. 452(7184), pages 220-224, March.
    2. David J. Foster & Matthew A. Wilson, 2006. "Reverse replay of behavioural sequences in hippocampal place cells during the awake state," Nature, Nature, vol. 440(7084), pages 680-683, March.
    3. Aniek Schoups & Rufin Vogels & Ning Qian & Guy Orban, 2001. "Practising orientation identification improves orientation coding in V1 neurons," Nature, Nature, vol. 412(6846), pages 549-553, August.
    4. Ariana R. Andrei & Sorin Pojoga & Roger Janz & Valentin Dragoi, 2019. "Integration of cortical population signals for visual perception," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    5. Jessica A. Cardin & Marie Carlén & Konstantinos Meletis & Ulf Knoblich & Feng Zhang & Karl Deisseroth & Li-Huei Tsai & Christopher I. Moore, 2009. "Driving fast-spiking cells induces gamma rhythm and controls sensory responses," Nature, Nature, vol. 459(7247), pages 663-667, June.
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