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A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein

Author

Listed:
  • Yiming Chen

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Dehui Kong

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Zongkuan Wang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Jiaqian Liu

    (Ningbo University)

  • Linghan Wang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Keli Dai

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Jialun Ji

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Wei Chen

    (Nanjing University)

  • Xiong Tang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Mingxing Wen

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Xu Zhang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Huajian Zhang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Chengzhi Jiao

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Li Sun

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Haiyan Wang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Xingru Fei

    (Yandu District Agricultural Science Research Institute)

  • Hong Guo

    (Yandu District Agricultural Science Research Institute)

  • Bingjian Sun

    (Henan Agricultural University)

  • Xiaorong Tao

    (Nanjing Agricultural University)

  • Wei Wang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Jian Yang

    (Ningbo University)

  • Xiue Wang

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

  • Jin Xiao

    (National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization/Zhongshan Biological Breeding Laboratory/CIC-MCP)

Abstract

Ym1 is the most widely utilized gene for wheat yellow mosaic virus (WYMV) disease control in worldwide wheat breeding. Here, we successfully isolated the responsible gene for Ym1. It encodes a typical CC-NBS-LRR type R protein, which is specifically expressed in root and induced upon WYMV infection. Ym1-mediated WYMV resistance is likely achieved by blocking viral transmission from the root cortex into steles, thereby preventing systemic movement to aerial tissues. Ym1 CC domain is essential for triggering cell death. Ym1 specifically interacts with WYMV coat protein, and this interaction leads to nucleocytoplasmic redistribution, a process for transitioning Ym1 from an auto-inhibited to an activated state. The activation subsequently elicits hypersensitive responses and establishes WYMV resistance. Ym1 is likely introgressed from the sub-genome Xn or Xc of polyploid Aegilops species. The findings highlight an exogenous-introgressed and root-specifically expressed R gene that confers WYMV resistance by recognizing the viral component.

Suggested Citation

  • Yiming Chen & Dehui Kong & Zongkuan Wang & Jiaqian Liu & Linghan Wang & Keli Dai & Jialun Ji & Wei Chen & Xiong Tang & Mingxing Wen & Xu Zhang & Huajian Zhang & Chengzhi Jiao & Li Sun & Haiyan Wang & , 2025. "A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58816-0
    DOI: 10.1038/s41467-025-58816-0
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    References listed on IDEAS

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    1. Hehong Zhang & Fengmin Wang & Weiqi Song & Zihang Yang & Lulu Li & Qiang Ma & Xiaoxiang Tan & Zhongyan Wei & Yanjun Li & Junmin Li & Fei Yan & Jianping Chen & Zongtao Sun, 2023. "Different viral effectors suppress hormone-mediated antiviral immunity of rice coordinated by OsNPR1," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Cheng Yuan & Cui Li & Lijie Yan & Andrew O Jackson & Zhiyong Liu & Chenggui Han & Jialin Yu & Dawei Li, 2011. "A High Throughput Barley Stripe Mosaic Virus Vector for Virus Induced Gene Silencing in Monocots and Dicots," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-16, October.
    3. Peng Liu & Chaonan Shi & Shuang Liu & Jiajia Lei & Qisen Lu & Haichao Hu & Yan Ren & Ning Zhang & Congwei Sun & Lu Chen & Yaoyao Jiang & Lixiao Feng & Tianye Zhang & Kaili Zhong & Jiaqian Liu & Juan Z, 2023. "A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
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