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An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination

Author

Listed:
  • Jun Guo

    (Ningbo University)

  • Tianye Zhang

    (Ningbo University)

  • Haoxin Xie

    (Ningbo University)

  • Haichao Hu

    (Ningbo University)

  • Chaonan Shi

    (Henan Agricultural University)

  • Yingjie Zhao

    (Ningbo University)

  • Jingliang Yin

    (Ningbo University)

  • Gecheng Xu

    (Ningbo University)

  • Zechi Wu

    (Ningbo University)

  • Pengkun Wang

    (Ningbo University)

  • Jiaqian Liu

    (Ningbo University)

  • Peng Liu

    (Ningbo University)

  • Kaili Zhong

    (Ningbo University)

  • Feng Chen

    (Henan Agricultural University)

  • Jianping Chen

    (Ningbo University)

  • Jian Yang

    (Ningbo University)

Abstract

Posttranscriptional and posttranslational modifications play crucial roles in plant immunity. However, how plants fine-tune such modifications to activate antiviral immunity remains unknown. Here, we report that the m6A methyltransferase TaHAKAI is utilized by wheat yellow mosaic virus (WYMV) to increase viral genomic m6A modification and promote viral replication. However, TaHAKAI also functions as an E3 ligase that targets the viral RNA silencing suppressor P2 for degradation and inhibits viral infection. A major allele of TaHAKAI in a susceptible cultivar exhibited reduced E3 ligase activity but not m6A methyltransferase activity, promoting viral infection. Interestingly, TaHAKAIR attenuates the stability of TaWPS1 (Wheat paired spikelets 1, WPS1) mRNA, the negative regulator of spike development, which might increase panicle length and spikelet number by modulating its m6A modification. Our study reveals a mechanism for balancing disease resistance and yield by fine-tuning m6A modification and ubiquitination.

Suggested Citation

  • Jun Guo & Tianye Zhang & Haoxin Xie & Haichao Hu & Chaonan Shi & Yingjie Zhao & Jingliang Yin & Gecheng Xu & Zechi Wu & Pengkun Wang & Jiaqian Liu & Peng Liu & Kaili Zhong & Feng Chen & Jianping Chen , 2025. "An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60199-1
    DOI: 10.1038/s41467-025-60199-1
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    References listed on IDEAS

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    1. Praveen Bawankar & Tina Lence & Chiara Paolantoni & Irmgard U. Haussmann & Migle Kazlauskiene & Dominik Jacob & Jan B. Heidelberger & Florian M. Richter & Mohanakarthik P. Nallasivan & Violeta Morin &, 2021. "Hakai is required for stabilization of core components of the m6A mRNA methylation machinery," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Peng Liu & Chaonan Shi & Shuang Liu & Jiajia Lei & Qisen Lu & Haichao Hu & Yan Ren & Ning Zhang & Congwei Sun & Lu Chen & Yaoyao Jiang & Lixiao Feng & Tianye Zhang & Kaili Zhong & Jiaqian Liu & Juan Z, 2023. "A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
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