IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45307-x.html
   My bibliography  Save this article

Causes of death among people living with metastatic cancer

Author

Listed:
  • Kyle Mani

    (Albert Einstein School of Medicine
    University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine)

  • Daxuan Deng

    (Penn State College of Medicine)

  • Christine Lin

    (Penn State Cancer Institute
    University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine)

  • Ming Wang

    (Case Western Reserve University)

  • Melinda L. Hsu

    (University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine)

  • Nicholas G. Zaorsky

    (University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine)

Abstract

Studying survivorship and causes of death in patients with advanced or metastatic cancer remains an important task. We characterize the causes of death among patients with metastatic cancer, across 13 cancer types and 25 non-cancer causes and predict the risk of death after diagnosis from the diagnosed cancer versus other causes (e.g., stroke, heart disease, etc.). Among 1,030,937 US (1992–2019) metastatic cancer survivors, 82.6% of patients (n = 688,529) died due to the diagnosed cancer, while 17.4% (n = 145,006) died of competing causes. Patients with lung, pancreas, esophagus, and stomach tumors are the most likely to die of their metastatic cancer, while those with prostate and breast cancer have the lowest likelihood. The median survival time among patients living with metastases is 10 months; our Fine and Gray competing risk model predicts 1 year survival with area under the receiver operating characteristic curve of 0.754 (95% CI [0.754, 0.754]). Leading non-cancer deaths are heart disease (32.4%), chronic obstructive and pulmonary disease (7.9%), cerebrovascular disease (6.1%), and infection (4.1%).

Suggested Citation

  • Kyle Mani & Daxuan Deng & Christine Lin & Ming Wang & Melinda L. Hsu & Nicholas G. Zaorsky, 2024. "Causes of death among people living with metastatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45307-x
    DOI: 10.1038/s41467-024-45307-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45307-x
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-45307-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kelsey C. Stoltzfus & Ying Zhang & Kathleen Sturgeon & Lawrence I. Sinoway & Daniel M. Trifiletti & Vernon M. Chinchilli & Nicholas G. Zaorsky, 2020. "Fatal heart disease among cancer patients," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    2. Nicholas G. Zaorsky & Ying Zhang & Leonard Tuanquin & Shirley M. Bluethmann & Henry S. Park & Vernon M. Chinchilli, 2019. "Suicide among cancer patients," Nature Communications, Nature, vol. 10(1), pages 1-7, December.
    3. Nicholas G. Zaorsky & Ying Zhang & Leila T. Tchelebi & Heath B. Mackley & Vernon M. Chinchilli & Brad E. Zacharia, 2019. "Stroke among cancer patients," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    4. Ronald B. Geskus, 2011. "Cause-Specific Cumulative Incidence Estimation and the Fine and Gray Model Under Both Left Truncation and Right Censoring," Biometrics, The International Biometric Society, vol. 67(1), pages 39-49, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Vanessa di Lego & Cássio M. Turra & Cibele Cesar, 2017. "Mortality selection among adults in Brazil: The survival advantage of Air Force officers," Demographic Research, Max Planck Institute for Demographic Research, Rostock, Germany, vol. 37(41), pages 1339-1350.
    2. Soyoung Kim & Yayun Xu & Mei‐Jie Zhang & Kwang‐Woo Ahn, 2020. "Stratified proportional subdistribution hazards model with covariate‐adjusted censoring weight for case‐cohort studies," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 47(4), pages 1222-1242, December.
    3. Yuqi Cai & Yuan Zhang & Wangnan Cao & Fengsu Hou & Meiqi Xin & Vivian Yawei Guo & Yang Deng & Shenghao Wang & Xinyi You & Jinghua Li, 2022. "Preliminary validation of the Chinese version of the Shame and Stigma Scale among patients with facial disfigurement from nasopharyngeal carcinoma," PLOS ONE, Public Library of Science, vol. 17(12), pages 1-12, December.
    4. repec:jss:jstsof:43:i13 is not listed on IDEAS
    5. Xufei Bian & Ling Yang & Dingxi Jiang & Adam J. Grippin & Yifan Ma & Shuang Wu & Linchong Wu & Xiaoyou Wang & Zhongjie Tang & Kaicheng Tang & Weidong Pan & Shiyan Dong & Betty Y. S. Kim & Wen Jiang & , 2024. "Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Qing Liu & Gong Tang & Joseph P. Costantino & Chung‐Chou H. Chang, 2020. "Landmark proportional subdistribution hazards models for dynamic prediction of cumulative incidence functions," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 69(5), pages 1145-1162, November.
    7. Deresa, Negera Wakgari & Van Keilegom, Ingrid, 2020. "A multivariate normal regression model for survival data subject to different types of dependent censoring," Computational Statistics & Data Analysis, Elsevier, vol. 144(C).
    8. Erik T. Parner & Per K. Andersen & Morten Overgaard, 2023. "Regression models for censored time-to-event data using infinitesimal jack-knife pseudo-observations, with applications to left-truncation," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(3), pages 654-671, July.
    9. Yuxue Jin & Tze Leung Lai, 2017. "A new approach to regression analysis of censored competing-risks data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(4), pages 605-625, October.
    10. Jackson P. Lautier & Vladimir Pozdnyakov & Jun Yan, 2022. "On the Convergence of Credit Risk in Current Consumer Automobile Loans," Papers 2211.09176, arXiv.org, revised Jan 2024.
    11. Zhang, Feipeng & Peng, Heng & Zhou, Yong, 2016. "Composite partial likelihood estimation for length-biased and right-censored data with competing risks," Journal of Multivariate Analysis, Elsevier, vol. 149(C), pages 160-176.
    12. Xiaocang Xu & Haoran Yang, 2022. "Elderly chronic diseases and catastrophic health expenditure: an important cause of Borderline Poor Families’ return to poverty in rural China," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-10, December.
    13. Xiaomeng Qi & Zhangsheng Yu, 2023. "Kernel regression for cause-specific hazard models with time-dependent coefficients," Computational Statistics, Springer, vol. 38(1), pages 263-283, March.
    14. Zhang, Qiaozhen & Dai, Hongsheng & Fu, Bo, 2016. "A proportional hazards model for time-to-event data with epidemiological bias," Journal of Multivariate Analysis, Elsevier, vol. 152(C), pages 224-236.
    15. Li, Ruosha & Peng, Limin, 2014. "Varying coefficient subdistribution regression for left-truncated semi-competing risks data," Journal of Multivariate Analysis, Elsevier, vol. 131(C), pages 65-78.
    16. Luisa Hofmann & Michael Heinrich & Hansjörg Baurecht & Berthold Langguth & Peter M. Kreuzer & Helge Knüttel & Michael F. Leitzmann & Corinna Seliger, 2023. "Suicide Mortality Risk among Patients with Lung Cancer—A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 20(5), pages 1-15, February.
    17. Pavlova, Elitsa & Signore, Simone, 2021. "The European venture capital landscape: An EIF perspective. Volume VI: The impact of VC on the exit and innovation outcomes of EIF-backed start-ups," EIF Working Paper Series 2021/70, European Investment Fund (EIF).
    18. Zhou, Yuying & Lao, Jiahui & Cao, Yiting & Wang, Qianqian & Wang, Qin & Tang, Fang, 2024. "Dynamic prediction of lung cancer suicide risk based on meteorological factors and clinical characteristics:A landmarking analysis approach," Social Science & Medicine, Elsevier, vol. 357(C).
    19. Guendalina Gentile & Stefano Tambuzzi & Raffaella Calati & Riccardo Zoja, 2022. "A Descriptive Cohort of Suicidal Cancer Patients: Analysis of the Autopsy Case Series from 1993 to 2019 in Milan (Italy)," IJERPH, MDPI, vol. 19(2), pages 1-14, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45307-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.