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Varying coefficient subdistribution regression for left-truncated semi-competing risks data

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  • Li, Ruosha
  • Peng, Limin

Abstract

Semi-competing risks data frequently arise in biomedical studies when time to a disease landmark event is subject to dependent censoring by death, the observation of which however is not precluded by the occurrence of the landmark event. In observational studies, the analysis of such data can be further complicated by left truncation. In this work, we study a varying coefficient subdistribution regression model for left-truncated semi-competing risks data. Our method appropriately accounts for the specifical truncation and censoring features of the data, and moreover has the flexibility to accommodate potentially varying covariate effects. The proposed method can be easily implemented and the resulting estimators are shown to have nice asymptotic properties. We also present inference, such as Kolmogorov–Smirnov type and Cramér–Von-Mises type hypothesis testing procedures for the covariate effects. Simulation studies and an application to the Denmark diabetes registry demonstrate good finite-sample performance and practical utility of the proposed method.

Suggested Citation

  • Li, Ruosha & Peng, Limin, 2014. "Varying coefficient subdistribution regression for left-truncated semi-competing risks data," Journal of Multivariate Analysis, Elsevier, vol. 131(C), pages 65-78.
    • Handle: RePEc:eee:jmvana:v:131:y:2014:i:c:p:65-78
    DOI: 10.1016/j.jmva.2014.06.005
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    References listed on IDEAS

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    1. Thomas H. Scheike & Mei‐Jie Zhang, 2007. "Direct Modelling of Regression Effects for Transition Probabilities in Multistate Models," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 34(1), pages 17-32, March.
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    9. Peng, Limin & Fine, Jason P., 2006. "Rank Estimation of Accelerated Lifetime Models With Dependent Censoring," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 1085-1093, September.
    10. Ronald B. Geskus, 2011. "Cause-Specific Cumulative Incidence Estimation and the Fine and Gray Model Under Both Left Truncation and Right Censoring," Biometrics, The International Biometric Society, vol. 67(1), pages 39-49, March.
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    Cited by:

    1. Erik T. Parner & Per K. Andersen & Morten Overgaard, 2023. "Regression models for censored time-to-event data using infinitesimal jack-knife pseudo-observations, with applications to left-truncation," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 29(3), pages 654-671, July.
    2. Ying Cui & Limin Peng, 2022. "Assessing dynamic covariate effects with survival data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(4), pages 675-699, October.
    3. Huijuan Ma & Limin Peng & Zhumin Zhang & HuiChuan J. Lai, 2018. "Generalized accelerated recurrence time model for multivariate recurrent event data with missing event type," Biometrics, The International Biometric Society, vol. 74(3), pages 954-965, September.

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