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Shifting patterns of dengue three years after Zika virus emergence in Brazil

Author

Listed:
  • Francesco Pinotti

    (University of Oxford)

  • Marta Giovanetti

    (Instituto Oswaldo Cruz, Fundação Oswaldo Cruz
    Fundação Oswaldo Cruz
    University of Campus Bio-Medico di Roma)

  • Maricelia Maia Lima

    (Universidade Estadual de Feira de Santana)

  • Erenilde Marques Cerqueira

    (Universidade Estadual de Feira de Santana)

  • Luiz C. J. Alcantara

    (Instituto Oswaldo Cruz, Fundação Oswaldo Cruz
    Fundação Oswaldo Cruz)

  • Sunetra Gupta

    (University of Oxford)

  • Mario Recker

    (University of Exeter
    University of Tübingen)

  • José Lourenço

    (Universidade Católica Portuguesa)

Abstract

In 2015, the Zika virus (ZIKV) emerged in Brazil, leading to widespread outbreaks in Latin America. Following this, many countries in these regions reported a significant drop in the circulation of dengue virus (DENV), which resurged in 2018-2019. We examine age-specific incidence data to investigate changes in DENV epidemiology before and after the emergence of ZIKV. We observe that incidence of DENV was concentrated in younger individuals during resurgence compared to 2013-2015. This trend was more pronounced in Brazilian states that had experienced larger ZIKV outbreaks. Using a mathematical model, we show that ZIKV-induced cross-protection alone, often invoked to explain DENV decline across Latin America, cannot explain the observed age-shift without also assuming some form of disease enhancement. Our results suggest that a sudden accumulation of population-level immunity to ZIKV could suppress DENV and reduce the mean age of DENV incidence via both protective and disease-enhancing interactions.

Suggested Citation

  • Francesco Pinotti & Marta Giovanetti & Maricelia Maia Lima & Erenilde Marques Cerqueira & Luiz C. J. Alcantara & Sunetra Gupta & Mario Recker & José Lourenço, 2024. "Shifting patterns of dengue three years after Zika virus emergence in Brazil," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44799-x
    DOI: 10.1038/s41467-024-44799-x
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    References listed on IDEAS

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    1. Samir Bhatt & Peter W. Gething & Oliver J. Brady & Jane P. Messina & Andrew W. Farlow & Catherine L. Moyes & John M. Drake & John S. Brownstein & Anne G. Hoen & Osman Sankoh & Monica F. Myers & Dylan , 2013. "The global distribution and burden of dengue," Nature, Nature, vol. 496(7446), pages 504-507, April.
    2. Anderson Fernandes Brito & Lais Ceschini Machado & Rachel J. Oidtman & Márcio Junio Lima Siconelli & Quan Minh Tran & Joseph R. Fauver & Rodrigo Dias de Oliveira Carvalho & Filipe Zimmer Dezordi & Myl, 2021. "Lying in wait: the resurgence of dengue virus after the Zika epidemic in Brazil," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Paulina Andrade & Ciara Gimblet-Ochieng & Faraz Modirian & Matthew Collins & Maritza Cárdenas & Leah C. Katzelnick & Magelda Montoya & Daniela Michlmayr & Guillermina Kuan & Angel Balmaseda & Josefina, 2019. "Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    4. Rebecca K. Borchering & Angkana T. Huang & Luis Mier-y-Teran-Romero & Diana P. Rojas & Isabel Rodriguez-Barraquer & Leah C. Katzelnick & Silvio D. Martinez & Gregory D. King & Stephanie C. Cinkovich &, 2019. "Impacts of Zika emergence in Latin America on endemic dengue transmission," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    5. Sean M Moore & Rachel J Oidtman & K James Soda & Amir S Siraj & Robert C Reiner Jr. & Christopher M Barker & T Alex Perkins, 2020. "Leveraging multiple data types to estimate the size of the Zika epidemic in the Americas," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(9), pages 1-25, September.
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