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Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut

Author

Listed:
  • Huimin Ye

    (University of Vienna
    University of Vienna)

  • Sabrina Borusak

    (University of Konstanz)

  • Claudia Eberl

    (Ludwig Maximilian University Munich)

  • Julia Krasenbrink

    (University of Vienna
    University of Vienna)

  • Anna S. Weiss

    (Ludwig Maximilian University Munich)

  • Song-Can Chen

    (University of Vienna)

  • Buck T. Hanson

    (University of Vienna
    Safety and Innovation FFoQSI GmbH
    University of Veterinary Medicine)

  • Bela Hausmann

    (Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna
    Medical University of Vienna)

  • Craig W. Herbold

    (University of Vienna
    University of Canterbury)

  • Manuel Pristner

    (University of Vienna)

  • Benjamin Zwirzitz

    (University of Vienna
    Safety and Innovation FFoQSI GmbH
    University of Veterinary Medicine
    University of Natural Resources and Life Sciences)

  • Benedikt Warth

    (University of Vienna
    Research Infrastructure and National EIRENE Hub)

  • Petra Pjevac

    (University of Vienna
    Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna)

  • David Schleheck

    (University of Konstanz)

  • Bärbel Stecher

    (Ludwig Maximilian University Munich
    partner site Ludwig Maximilian University Munich)

  • Alexander Loy

    (University of Vienna
    Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna)

Abstract

Taurine-respiring gut bacteria produce H2S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of T. muris in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundance of Salmonella enterica, which showed reduced expression of galactonate catabolism genes. Re-analysis of metagenome data from a previous study further suggested that T. muris can contribute to protection against pathogens by the commensal mouse gut microbiota. Together, we show the realized physiological niche of a key murine gut sulfidogen and its interactions with selected gut microbiota members.

Suggested Citation

  • Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41008-z
    DOI: 10.1038/s41467-023-41008-z
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