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Effects of fecal microbiota transplantation in metabolic syndrome: A meta-analysis of randomized controlled trials

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  • Bo Qiu
  • JiaXu Liang
  • Cong Li

Abstract

Objective: The prevalence of obesity and type 2 diabetes is rapidly increasing worldwide, posing serious threats to human health. This study aimed to evaluate the role of FMT in the treatment of obesity and/or metabolic syndrome and its impact on clinically important parameters. Methods: We searched Medline, Embase, and Cochrane Library databases up to April 31, 2022 and further assessed articles that met the eligibility criteria. Mean differences and 95% confidence intervals were used to analyze continuous data. The I2 statistic was used to measure study heterogeneity. Univariate meta-regression or subgroup analyses were performed to explore the covariates that might contribute to heterogeneity. Potential publication bias was assessed using the Egger’s test. We used the GRADEpro guideline development tool to assess the quality of the evidence. Results: Nine studies, comprising 303 participants, were included in the meta-analysis. In the short-term outcomes (

Suggested Citation

  • Bo Qiu & JiaXu Liang & Cong Li, 2023. "Effects of fecal microbiota transplantation in metabolic syndrome: A meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 18(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0288718
    DOI: 10.1371/journal.pone.0288718
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    1. Lawrence A. David & Corinne F. Maurice & Rachel N. Carmody & David B. Gootenberg & Julie E. Button & Benjamin E. Wolfe & Alisha V. Ling & A. Sloan Devlin & Yug Varma & Michael A. Fischbach & Sudha B. , 2014. "Diet rapidly and reproducibly alters the human gut microbiome," Nature, Nature, vol. 505(7484), pages 559-563, January.
    2. Adela Hruby & Frank Hu, 2015. "The Epidemiology of Obesity: A Big Picture," PharmacoEconomics, Springer, vol. 33(7), pages 673-689, July.
    3. repec:plo:pone00:0020466 is not listed on IDEAS
    4. repec:plo:pone00:0171308 is not listed on IDEAS
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