IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v529y2016i7585d10.1038_nature16504.html
   My bibliography  Save this article

Diet-induced extinctions in the gut microbiota compound over generations

Author

Listed:
  • Erica D. Sonnenburg

    (Stanford University School of Medicine)

  • Samuel A. Smits

    (Stanford University School of Medicine)

  • Mikhail Tikhonov

    (Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University
    Kavli Institute for Bionano Science and Technology, Harvard University)

  • Steven K. Higginbottom

    (Stanford University School of Medicine)

  • Ned S. Wingreen

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Justin L. Sonnenburg

    (Stanford University School of Medicine)

Abstract

In mice on a low microbiota-accessible carbohydrate (MAC) diet, the diversity of the gut microbiota is depleted, and the effect is transferred and compounded over generations; this phenotype is only reversed after supplementation of the missing taxa via faecal microbiota transplantation, suggesting dietary intervention alone may by insufficient at managing diseases characterized by a dysbiotic microbiota.

Suggested Citation

  • Erica D. Sonnenburg & Samuel A. Smits & Mikhail Tikhonov & Steven K. Higginbottom & Ned S. Wingreen & Justin L. Sonnenburg, 2016. "Diet-induced extinctions in the gut microbiota compound over generations," Nature, Nature, vol. 529(7585), pages 212-215, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16504
    DOI: 10.1038/nature16504
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature16504
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature16504?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Alan C. Logan & Susan L. Prescott, 2017. "Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift," Challenges, MDPI, vol. 8(2), pages 1-24, September.
    3. Giuliano Bonanomi & Mohamed Idbella & Ahmed M. Abd-ElGawad, 2021. "Microbiota Management for Effective Disease Suppression: A Systematic Comparison between Soil and Mammals Gut," Sustainability, MDPI, vol. 13(14), pages 1-16, July.
    4. Bo Tang & Li Tang & Shengpeng Li & Shuang Liu & Jialin He & Pan Li & Sumin Wang & Min Yang & Longhui Zhang & Yuanyuan Lei & Dianji Tu & Xuefeng Tang & Hua Hu & Qin Ouyang & Xia Chen & Shiming Yang, 2023. "Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Ren Dodge & Eric W. Jones & Haolong Zhu & Benjamin Obadia & Daniel J. Martinez & Chenhui Wang & Andrés Aranda-Díaz & Kevin Aumiller & Zhexian Liu & Marco Voltolini & Eoin L. Brodie & Kerwyn Casey Huan, 2023. "A symbiotic physical niche in Drosophila melanogaster regulates stable association of a multi-species gut microbiota," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Susan L. Prescott & Alan C. Logan, 2017. "Down to Earth: Planetary Health and Biophilosophy in the Symbiocene Epoch," Challenges, MDPI, vol. 8(2), pages 1-22, August.
    7. Karen D. Corbin & Elvis A. Carnero & Blake Dirks & Daria Igudesman & Fanchao Yi & Andrew Marcus & Taylor L. Davis & Richard E. Pratley & Bruce E. Rittmann & Rosa Krajmalnik-Brown & Steven R. Smith, 2023. "Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16504. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.