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Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice

Author

Listed:
  • Jane M. Natividad

    (Université Paris–Saclay)

  • Bruno Lamas

    (Université Paris–Saclay
    APHP Laboratoire des Biomolécules (LBM), 27 rue de Chaligny)

  • Hang Phuong Pham

    (ILTOO Pharma)

  • Marie-Laure Michel

    (Université Paris–Saclay)

  • Dominique Rainteau

    (APHP Laboratoire des Biomolécules (LBM), 27 rue de Chaligny
    PSL Research University)

  • Chantal Bridonneau

    (Université Paris–Saclay)

  • Gregory da Costa

    (Université Paris–Saclay)

  • Johan van Hylckama Vlieg

    (Danone Nutricia Research)

  • Bruno Sovran

    (Université Paris–Saclay)

  • Celia Chamignon

    (Université Paris–Saclay)

  • Julien Planchais

    (Université Paris–Saclay)

  • Mathias L. Richard

    (Université Paris–Saclay)

  • Philippe Langella

    (Université Paris–Saclay)

  • Patrick Veiga

    (Danone Nutricia Research)

  • Harry Sokol

    (Université Paris–Saclay
    APHP Laboratoire des Biomolécules (LBM), 27 rue de Chaligny
    PSL Research University
    Assistance Publique—Hopitaux de Paris, UPMC)

Abstract

Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly understood. Here, we showed that B. wadsworthia synergizes with high fat diet (HFD) to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis reveal pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by B. wadsworthia. Pharmacological suppression of B. wadsworthia-associated inflammation demonstrate the bacterium’s intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Administration of the probiotic Lactobacillus rhamnosus CNCM I-3690 limits B. wadsworthia-induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results suggest a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.

Suggested Citation

  • Jane M. Natividad & Bruno Lamas & Hang Phuong Pham & Marie-Laure Michel & Dominique Rainteau & Chantal Bridonneau & Gregory da Costa & Johan van Hylckama Vlieg & Bruno Sovran & Celia Chamignon & Julie, 2018. "Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05249-7
    DOI: 10.1038/s41467-018-05249-7
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    Cited by:

    1. Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Wen-Long Sun & Sha Hua & Xin-Yu Li & Liang Shen & Hao Wu & Hong-Fang Ji, 2023. "Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Efrat Muller & Itamar Shiryan & Elhanan Borenstein, 2024. "Multi-omic integration of microbiome data for identifying disease-associated modules," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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