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Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters

Author

Listed:
  • Liang Zhang

    (Xiamen University)

  • Yao Jiang

    (Xiamen University)

  • Jinhang He

    (Xiamen University)

  • Junyu Chen

    (Xiamen University)

  • Ruoyao Qi

    (Xiamen University)

  • Lunzhi Yuan

    (Xiamen University)

  • Tiange Shao

    (Tsinghua University)

  • Hui Zhao

    (National Institute for Food and Drug Control)

  • Congjie Chen

    (Xiamen University)

  • Yaode Chen

    (Xiamen University)

  • Xijing Wang

    (Xiamen University)

  • Xing Lei

    (Xiamen University)

  • Qingxiang Gao

    (Xiamen University)

  • Chunlan Zhuang

    (Xiamen University)

  • Ming Zhou

    (Xiamen University)

  • Jian Ma

    (Xiamen University)

  • Wei Liu

    (Xiamen University)

  • Man Yang

    (Xiamen University)

  • Rao Fu

    (Xiamen University)

  • Yangtao Wu

    (Xiamen University)

  • Feng Chen

    (Xiamen University)

  • Hualong Xiong

    (Xiamen University)

  • Meifeng Nie

    (Xiamen University)

  • Yiyi Chen

    (Xiamen University)

  • Kun Wu

    (Xiamen University)

  • Mujin Fang

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Yingbin Wang

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Zizheng Zheng

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Shoujie Huang

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Shengxiang Ge

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Shih Chin Cheng

    (Xiamen University)

  • Huachen Zhu

    (The University of Hong Kong
    Shantou University)

  • Tong Cheng

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Quan Yuan

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Ting Wu

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Jun Zhang

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Yixin Chen

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Tianying Zhang

    (Xiamen University
    Xiang An Biomedicine Laboratory)

  • Changgui Li

    (National Institute for Food and Drug Control)

  • Hai Qi

    (Tsinghua University)

  • Yi Guan

    (The University of Hong Kong
    Shantou University)

  • Ningshao Xia

    (Xiamen University
    Xiang An Biomedicine Laboratory)

Abstract

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and “anatomical escape” characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respiratory tract protection to guide broader vaccines development. Here we investigate immune responses induced by an NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides broad-spectrum protection against SARS-CoV-2 variants in hamsters. Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. It restrains the inflammatory response by suppressing early phase viral load post SARS-CoV-2 challenge and attenuating pro-inflammatory cytokine (Il6, Il1b, and Ifng) levels, thereby reducing excess immune-induced tissue injury compared with the control group. By inducing local cellular immunity and trained immunity, intranasal delivery of NS1-deleted influenza virus vectored vaccine represents a broad-spectrum COVID-19 vaccine strategy to reduce disease burden.

Suggested Citation

  • Liang Zhang & Yao Jiang & Jinhang He & Junyu Chen & Ruoyao Qi & Lunzhi Yuan & Tiange Shao & Hui Zhao & Congjie Chen & Yaode Chen & Xijing Wang & Xing Lei & Qingxiang Gao & Chunlan Zhuang & Ming Zhou &, 2023. "Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39560-9
    DOI: 10.1038/s41467-023-39560-9
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    References listed on IDEAS

    as
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