IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37626-2.html
   My bibliography  Save this article

A precision environmental health approach to prevention of human disease

Author

Listed:
  • Andrea Baccarelli

    (Columbia University Mailman School of Public Health)

  • Dana C. Dolinoy

    (University of Michigan School of Public Health)

  • Cheryl Lyn Walker

    (Baylor College of Medicine)

Abstract

Human health is determined by the interaction of our environment with the genome, epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic landscape of cells and tissues. Precision environmental health is an emerging field leveraging environmental and system-level (‘omic) data to understand underlying environmental causes of disease, identify biomarkers of exposure and response, and develop new prevention and intervention strategies. In this article we provide real-life illustrations of the utility of precision environmental health approaches, identify current challenges in the field, and outline new opportunities to promote health through a precision environmental health framework.

Suggested Citation

  • Andrea Baccarelli & Dana C. Dolinoy & Cheryl Lyn Walker, 2023. "A precision environmental health approach to prevention of human disease," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37626-2
    DOI: 10.1038/s41467-023-37626-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37626-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37626-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hannah Lui Park, 2020. "Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention," IJERPH, MDPI, vol. 17(4), pages 1-18, February.
    2. R. Gacesa & A. Kurilshikov & A. Vich Vila & T. Sinha & M. A. Y. Klaassen & L. A. Bolte & S. Andreu-Sánchez & L. Chen & V. Collij & S. Hu & J. A. M. Dekens & V. C. Lenters & J. R. Björk & J. C. Swarte , 2022. "Environmental factors shaping the gut microbiome in a Dutch population," Nature, Nature, vol. 604(7907), pages 732-739, April.
    3. Angel Hsu & Glenn Sheriff & Tirthankar Chakraborty & Diego Manya, 2021. "Publisher Correction: Disproportionate exposure to urban heat island intensity across major US cities," Nature Communications, Nature, vol. 12(1), pages 1-1, December.
    4. Giacomo Cavalli & Edith Heard, 2019. "Advances in epigenetics link genetics to the environment and disease," Nature, Nature, vol. 571(7766), pages 489-499, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nikos Stratakis & Augusto Anguita-Ruiz & Lorenzo Fabbri & Léa Maitre & Juan R. González & Sandra Andrusaityte & Xavier Basagaña & Eva Borràs & Hector C. Keun & Lida Chatzi & David V. Conti & Jesse Goo, 2025. "Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinants," Nature Communications, Nature, vol. 16(1), pages 1-15, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Noa Levin, 2023. "Book review essay: City, Climate and Architecture; Coping with Urban Climates," Urban Studies, Urban Studies Journal Limited, vol. 60(13), pages 2725-2730, October.
    2. Qiang Zhang & Sai Ma & Zhengzhi Liu & Bohan Zhu & Zirui Zhou & Gaoshan Li & J. Javier Meana & Javier González-Maeso & Chang Lu, 2023. "Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Wan Ting Katty Huang & Pierre Masselot & Elie Bou-Zeid & Simone Fatichi & Athanasios Paschalis & Ting Sun & Antonio Gasparrini & Gabriele Manoli, 2023. "Economic valuation of temperature-related mortality attributed to urban heat islands in European cities," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. van Dijk, Ingrid K. & Nilsson, Therese & Quaranta, Luciana, 2024. "Disease exposure in infancy affects women's reproductive outcomes and offspring health in southern Sweden 1905–2000," Social Science & Medicine, Elsevier, vol. 347(C).
    5. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    6. Ivan Rudik & Derek Lemoine & Antonia Marcheva, 2025. "Equity and Efficiency in the Bipartisan Infrastructure Law’s Adaptation Investments," Environmental and Energy Policy and the Economy, University of Chicago Press, vol. 6(1), pages 65-100.
    7. Michael J. Allen & Daniel J. Vecellio & Jeremy S. Hoffman, 2025. "Evaluating the relationship between heat-related illness and cooling center location in Virginia," Natural Hazards: Journal of the International Society for the Prevention and Mitigation of Natural Hazards, Springer;International Society for the Prevention and Mitigation of Natural Hazards, vol. 121(4), pages 4293-4308, March.
    8. Luke J. Harrington & Kristie L. Ebi & David J. Frame & Friederike E. L. Otto, 2022. "Integrating attribution with adaptation for unprecedented future heatwaves," Climatic Change, Springer, vol. 172(1), pages 1-7, May.
    9. C. Grislain-Letremy & J. Sixou & A. Sotura, 2024. "Urban Heat Islands and Inequalities: Evidence from French Cities," Documents de Travail de l'Insee - INSEE Working Papers 2024-21, Institut National de la Statistique et des Etudes Economiques.
    10. Léa Maitre & Mariona Bustamante & Carles Hernández-Ferrer & Denise Thiel & Chung-Ho E. Lau & Alexandros P. Siskos & Marta Vives-Usano & Carlos Ruiz-Arenas & Dolors Pelegrí-Sisó & Oliver Robinson & Dan, 2022. "Multi-omics signatures of the human early life exposome," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    11. Georges P. Schmartz & Jacqueline Rehner & Miriam J. Schuff & Leidy-Alejandra G. Molano & Sören L. Becker & Marcin Krawczyk & Azat Tagirdzhanov & Alexey Gurevich & Richard Francke & Rolf Müller & Veren, 2024. "Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    12. Yadid M. Algavi & Elhanan Borenstein, 2023. "A data-driven approach for predicting the impact of drugs on the human microbiome," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    13. Bakhtsiyarava, Maryia & Schinasi, Leah H. & Sánchez, Brisa N. & Dronova, Iryna & Kephart, Josiah L. & Ju, Yang & Gouveia, Nelson & Caiaffa, Waleska Teixeira & O'Neill, Marie S. & Yamada, Goro & Arunac, 2023. "Modification of temperature-related human mortality by area-level socioeconomic and demographic characteristics in Latin American cities," Social Science & Medicine, Elsevier, vol. 317(C).
    14. Brandon Hickman & Anne Salonen & Alise J. Ponsero & Roosa Jokela & Kaija-Leena Kolho & Willem M. Vos & Katri Korpela, 2024. "Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    15. Suzanne Mavoa & Daniel Keevers & Stefan C. Kane & Melissa Wake & Rachel Tham & Kate Lycett & Yen Ting Wong & Katherine Chong, 2021. "Parental Preconception Exposures to Outdoor Neighbourhood Environments and Adverse Birth Outcomes: A Protocol for a Scoping Review and Evidence Map," IJERPH, MDPI, vol. 18(17), pages 1-10, August.
    16. Daniel Chang & Vinod K. Gupta & Benjamin Hur & Sergio Cobo-López & Kevin Y. Cunningham & Nam Soo Han & Insuk Lee & Vanessa L. Kronzer & Levi M. Teigen & Lioudmila V. Karnatovskaia & Erin E. Longbrake , 2024. "Gut Microbiome Wellness Index 2 enhances health status prediction from gut microbiome taxonomic profiles," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    17. Rebeca de Jesús Crespo & Rachel Elba Rogers, 2021. "Habitat Segregation Patterns of Container Breeding Mosquitos: The Role of Urban Heat Islands, Vegetation Cover, and Income Disparity in Cemeteries of New Orleans," IJERPH, MDPI, vol. 19(1), pages 1-16, December.
    18. Jonathon P. Schuldt & Adam R. Pearson, 2023. "Public recognition of climate change inequities within the United States," Climatic Change, Springer, vol. 176(8), pages 1-14, August.
    19. Mattia Zaghi & Federica Banfi & Luca Massimino & Monica Volpin & Edoardo Bellini & Simone Brusco & Ivan Merelli & Cristiana Barone & Michela Bruni & Linda Bossini & Luigi Antonio Lamparelli & Laura Pi, 2023. "Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    20. Claire Conzelmann & Jeremy Hoffman & Toan Phan & Arianna Salazar-Miranda, 2022. "Long-term Effects of Redlining on Environmental Risk Exposure," Working Paper 22-09R, Federal Reserve Bank of Richmond.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37626-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.