IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-36223-7.html
   My bibliography  Save this article

Long-term gastrointestinal outcomes of COVID-19

Author

Listed:
  • Evan Xu

    (VA Saint Louis Health Care System)

  • Yan Xie

    (VA Saint Louis Health Care System
    Veterans Research and Education Foundation of Saint Louis
    Saint Louis University)

  • Ziyad Al-Aly

    (VA Saint Louis Health Care System
    Veterans Research and Education Foundation of Saint Louis
    Washington University School of Medicine
    VA Saint Louis Health Care System)

Abstract

A comprehensive evaluation of the risks and 1-year burdens of gastrointestinal disorders in the post-acute phase of COVID-19 is needed but is not yet available. Here we use the US Department of Veterans Affairs national health care databases to build a cohort of 154,068 people with COVID-19, 5,638,795 contemporary controls, and 5,859,621 historical controls to estimate the risks and 1-year burdens of a set of pre-specified incident gastrointestinal outcomes. We show that beyond the first 30 days of infection, people with COVID-19 exhibited increased risks and 1-year burdens of incident gastrointestinal disorders spanning several disease categories including motility disorders, acid related disorders (dyspepsia, gastroesophageal reflux disease, peptic ulcer disease), functional intestinal disorders, acute pancreatitis, hepatic and biliary disease. The risks were evident in people who were not hospitalized during the acute phase of COVID-19 and increased in a graded fashion across the severity spectrum of the acute phase of COVID-19 (non-hospitalized, hospitalized, and admitted to intensive care). The risks were consistent in comparisons including the COVID-19 vs the contemporary control group and COVID-19 vs the historical control group as the referent category. Altogether, our results show that people with SARS-CoV-2 infection are at increased risk of gastrointestinal disorders in the post-acute phase of COVID-19. Post-covid care should involve attention to gastrointestinal health and disease.

Suggested Citation

  • Evan Xu & Yan Xie & Ziyad Al-Aly, 2023. "Long-term gastrointestinal outcomes of COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36223-7
    DOI: 10.1038/s41467-023-36223-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-36223-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-36223-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ziyad Al-Aly & Yan Xie & Benjamin Bowe, 2021. "High-dimensional characterization of post-acute sequelae of COVID-19," Nature, Nature, vol. 594(7862), pages 259-264, June.
    2. Callard, Felicity & Perego, Elisa, 2021. "How and why patients made Long Covid," Social Science & Medicine, Elsevier, vol. 268(C).
    3. Yan Xie & Benjamin Bowe & Ziyad Al-Aly, 2021. "Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chengxi Zang & Yongkang Zhang & Jie Xu & Jiang Bian & Dmitry Morozyuk & Edward J. Schenck & Dhruv Khullar & Anna S. Nordvig & Elizabeth A. Shenkman & Russell L. Rothman & Jason P. Block & Kristin Lyma, 2023. "Data-driven analysis to understand long COVID using electronic health records from the RECOVER initiative," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ivan Chun Hang Lam & Ran Zhang & Kenneth Keng Cheung Man & Carlos King Ho Wong & Celine Sze Ling Chui & Francisco Tsz Tsun Lai & Xue Li & Esther Wai Yin Chan & Chak Sing Lau & Ian Chi Kei Wong & Eric , 2024. "Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Rúbens Prince dos Santos Alves & Julia Timis & Robyn Miller & Kristen Valentine & Paolla Beatriz Almeida Pinto & Andrew Gonzalez & Jose Angel Regla-Nava & Erin Maule & Michael N. Nguyen & Norazizah Sh, 2024. "Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Jacqueline A. Krysa & Sidney Horlick & Kiran Pohar Manhas & Katharina Kovacs Burns & Mikayla Buell & Maria J. Santana & Kristine Russell & Elizabeth Papathanassoglou & Chester Ho, 2023. "Accessing Care Services for Long COVID Sufferers in Alberta, Canada: A Random, Cross-Sectional Survey Study," IJERPH, MDPI, vol. 20(15), pages 1-14, July.
    5. Ainur T. Tauekelova & Zhanar Kalila & Akerke Bakhtiyar & Zarina Sautbayeva & Polina Len & Aliya Sailybayeva & Sadyk Khamitov & Nazira Kadroldinova & Natasha S. Barteneva & Makhabbat S. Bekbossynova, 2023. "Association of Lung Fibrotic Changes and Cardiological Dysfunction with Comorbidities in Long COVID-19 Cohort," IJERPH, MDPI, vol. 20(3), pages 1-18, January.
    6. Vanessa Bertuzzi & Michelle Semonella & Gianluca Castelnuovo & Gerhard Andersson & Giada Pietrabissa, 2022. "Synthesizing Stakeholders Perspectives on Online Psychological Interventions to Improve the Mental Health of the Italian Population during the COVID-19 Pandemic: An Online Survey Study," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
    7. Matthew Whitaker & Joshua Elliott & Marc Chadeau-Hyam & Steven Riley & Ara Darzi & Graham Cooke & Helen Ward & Paul Elliott, 2022. "Persistent COVID-19 symptoms in a community study of 606,434 people in England," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    8. Daniel M. Altmann & Catherine J. Reynolds & George Joy & Ashley D. Otter & Joseph M. Gibbons & Corinna Pade & Leo Swadling & Mala K. Maini & Tim Brooks & Amanda Semper & Áine McKnight & Mahdad Noursad, 2023. "Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    9. Michal Matuszewski & Yurii Reznikov & Michal Pruc & Frank W. Peacock & Alla Navolokina & Raúl Júarez-Vela & Lukasz Jankowski & Zubaid Rafique & Lukasz Szarpak, 2022. "Prognostic Performance of Cystatin C in COVID-19: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(21), pages 1-10, November.
    10. Roth, Phillip H. & Gadebusch-Bondio, Mariacarla, 2022. "The contested meaning of “long COVID” – Patients, doctors, and the politics of subjective evidence," Social Science & Medicine, Elsevier, vol. 292(C).
    11. Rohitash Chandra & Ayush Jain & Divyanshu Singh Chauhan, 2022. "Deep learning via LSTM models for COVID-19 infection forecasting in India," PLOS ONE, Public Library of Science, vol. 17(1), pages 1-28, January.
    12. Tianchu Lyu & Nicole Hair & Nicholas Yell & Zhenlong Li & Shan Qiao & Chen Liang & Xiaoming Li, 2021. "Temporal Geospatial Analysis of COVID-19 Pre-Infection Determinants of Risk in South Carolina," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    13. Yan Xie & Benjamin Bowe & Ziyad Al-Aly, 2021. "Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    14. Leoni-Johanna Speichert & Adam Schweda & Oliver Witzke & Margarethe Konik & Hana Rohn & Mark Stettner & Venja Musche & Klaas Herchert & Madeleine Fink & Sheila Geiger & Alexander Bäuerle & Eva-Maria S, 2022. "Fear of Death during COVID-19 Does Not Explain Post-Infection Depression Symptoms beyond Reported Symptoms during the Infection in COVID-19 Survivors," IJERPH, MDPI, vol. 19(21), pages 1-10, October.
    15. Carlos M. Pérez-Lara & Doris D. Lara-Malca & Luz A. Baltodano-Nontol & Jessica E. Vicuña-Villacorta & Liliana M. Haro-León & Julio A. Rodríguez-Azabache, 2024. "Advances in Studies on Psychological Symptoms in Patients Surviving Covid-19: A Bibliometric Analysis," Academic Journal of Interdisciplinary Studies, Richtmann Publishing Ltd, vol. 13, January.
    16. Wangzi Xu & Yu Cao & Lin Wu, 2023. "No Causal Effects Detected in COVID-19 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two Sample Mendelian Randomization Study," IJERPH, MDPI, vol. 20(3), pages 1-13, January.
    17. Mullard, Jordan C.R. & Kawalek, Jessica & Parkin, Amy & Rayner, Clare & Mir, Ghazala & Sivan, Manoj & Greenhalgh, Trisha, 2023. "Towards evidence-based and inclusive models of peer support for long covid: A hermeneutic systematic review," Social Science & Medicine, Elsevier, vol. 320(C).
    18. Alicja Mińko & Agnieszka Turoń-Skrzypińska & Aleksandra Rył & Natalia Tomska & Zuzanna Bereda & Iwona Rotter, 2022. "Searching for Factors Influencing the Severity of the Symptoms of Long COVID," IJERPH, MDPI, vol. 19(13), pages 1-11, June.
    19. Turner, Melody & Beckwith, Helen & Spratt, Tanisha & Vallejos, Elvira Perez & Coughlan, Barry, 2023. "The #longcovid revolution: A reflexive thematic analysis," Social Science & Medicine, Elsevier, vol. 333(C).
    20. Giuseppe Craparo & Valentina Lucia La Rosa & Elena Commodari & Graziella Marino & Michela Vezzoli & Palmira Faraci & Carmelo Mario Vicario & Gabriella Serena Cinà & Morena Colombi & Giuseppe Arcoleo &, 2022. "What Is the Role of Psychological Factors in Long COVID Syndrome? Latent Class Analysis in a Sample of Patients Recovered from COVID-19," IJERPH, MDPI, vol. 20(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36223-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.