IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-35258-6.html
   My bibliography  Save this article

Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice

Author

Listed:
  • Dan Chen

    (Albert Einstein College of Medicine
    People’s Hospital of Zhengzhou University)

  • Yong Qi

    (People’s Hospital of Zhengzhou University)

  • Jia Zhang

    (Albert Einstein College of Medicine
    People’s Hospital of Zhengzhou University)

  • Yunlei Yang

    (Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

Abstract

The role of non-neuronal glial cells in the regulation of adipose sympathetic nerve activity and adipocyte functions such as white adipose tissue lipid lipolysis is poorly understood. Here, we combine chemo/optogenetic manipulations of medio-basal hypothalamic astrocytes, real-time fiber photometry monitoring of white adipose tissue norepinephrine (NE) contents and nerve activities, electrophysiological recordings of local sympathetic inputs to inguinal white adipose tissue (iWAT), and adipose tissue lipid lipolytic assays to define the functional roles of hypothalamic astrocytes in the regulation of iWAT sympathetic outflow and lipolysis. Our results show that astrocyte stimulation elevates iWAT NE contents, excites sympathetic neural inputs and promotes lipolysis. Mechanistically, we find that sympathetic paravertebral ganglia (PG) partake in those astrocyte effects. We also find that astrocyte stimulation excites pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH), and chemogenetic inhibition of POMC neurons blunts the effects induced by astrocyte stimulation. While we cannot exclude potential roles played by other cell populations such as microglia, our findings in this study reveal a central astrocyte-peripheral adipocyte axis modulating sympathetic drive to adipose tissues and adipocyte functions, one that might serve as a target for therapeutic intervention in the treatment of obesity.

Suggested Citation

  • Dan Chen & Yong Qi & Jia Zhang & Yunlei Yang, 2022. "Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35258-6
    DOI: 10.1038/s41467-022-35258-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35258-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35258-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Gertrudis Perea & Aimei Yang & Edward S. Boyden & Mriganka Sur, 2014. "Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo," Nature Communications, Nature, vol. 5(1), pages 1-12, May.
    2. Putianqi Wang & Ken H. Loh & Michelle Wu & Donald A. Morgan & Marc Schneeberger & Xiaofei Yu & Jingyi Chi & Christin Kosse & Damian Kim & Kamal Rahmouni & Paul Cohen & Jeffrey Friedman, 2020. "A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue," Nature, Nature, vol. 583(7818), pages 839-844, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jae Woo Park & Se Eun Park & Wuhyun Koh & Won Hee Jang & Jong Han Choi & Eun Roh & Gil Myoung Kang & Seong Jun Kim & Hyo Sun Lim & Chae Beom Park & So Yeon Jeong & Sang Yun Moon & Chan Hee Lee & Sang , 2024. "Hypothalamic astrocyte NAD+ salvage pathway mediates the coupling of dietary fat overconsumption in a mouse model of obesity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Junli Zhao & Jinyi Sun & Yang Zheng & Yanrong Zheng & Yuying Shao & Yulan Li & Fan Fei & Cenglin Xu & Xiuxiu Liu & Shuang Wang & Yeping Ruan & Jinggen Liu & Shumin Duan & Zhong Chen & Yi Wang, 2022. "Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Elisa Duregotti & Christina M. Reumiller & Ursula Mayr & Maria Hasman & Lukas E. Schmidt & Sean A. Burnap & Konstantinos Theofilatos & Javier Barallobre-Barreiro & Arne Beran & Maria Grandoch & Alessa, 2022. "Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Yong Hu & Liu Liu & Yong Chen & Xiaohui Zhang & Haifeng Zhou & Sheng Hu & Xu Li & Meixin Li & Juanjuan Li & Siyuan Cheng & Yong Liu & Yancheng Xu & Wei Yan, 2023. "Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Zhao, Jinyi & Yu, Ying & Wang, Qingyun, 2022. "Dynamical regulation of epileptiform discharges caused by abnormal astrocyte function with optogenetic stimulation," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    5. Woo-Hyun Cho & Kyungchul Noh & Byung Hun Lee & Ellane Barcelon & Sang Beom Jun & Hye Yoon Park & Sung Joong Lee, 2022. "Hippocampal astrocytes modulate anxiety-like behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35258-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.