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Brain-derived neurotrophic factor in diabetes mellitus: A systematic review and meta-analysis

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  • Fatemeh Moosaie
  • Soheil Mohammadi
  • Amene Saghazadeh
  • Fatemeh Dehghani Firouzabadi
  • Nima Rezaei

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor expressed in several tissues, including the brain, gut, and pancreas. Activation of the BDNF/TrkB/CREB reduces hepatic gluconeogenesis, induces hepatic insulin signal transduction, and protects against pancreatic beta-cell loss in diabetes mellitus (DM). Several studies have investigated the possible association between BDNF and DM and its complications, but the results have been conflicting. Aim: In the present study, we aimed at systematically reviewing the literature on the serum and plasma levels of BDNF in DM and its subgroups such as T2DM, DM patients with depression, and patients with retinopathy. Methods: A comprehensive search was conducted in PubMed, Scopus, and Web of Science. We identified 28 eligible studies and calculated the standardized mean difference (SMD) of outcomes as an effect measure. Results: The meta-analysis included 2734 patients with DM and 6004 controls. Serum BDNF levels were significantly lower in patients with DM vs. controls (SMD = -1.00, P

Suggested Citation

  • Fatemeh Moosaie & Soheil Mohammadi & Amene Saghazadeh & Fatemeh Dehghani Firouzabadi & Nima Rezaei, 2023. "Brain-derived neurotrophic factor in diabetes mellitus: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 18(2), pages 1-23, February.
    • Handle: RePEc:plo:pone00:0268816
    DOI: 10.1371/journal.pone.0268816
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    References listed on IDEAS

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    1. Putianqi Wang & Ken H. Loh & Michelle Wu & Donald A. Morgan & Marc Schneeberger & Xiaofei Yu & Jingyi Chi & Christin Kosse & Damian Kim & Kamal Rahmouni & Paul Cohen & Jeffrey Friedman, 2020. "A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue," Nature, Nature, vol. 583(7818), pages 839-844, July.
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