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Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

Author

Listed:
  • Gertrudis Perea

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Instituto Cajal, CSIC,)

  • Aimei Yang

    (Media Lab, Massachusetts Institute of Technology)

  • Edward S. Boyden

    (Media Lab, Massachusetts Institute of Technology
    McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Mriganka Sur

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

Abstract

Astrocytes play important roles in synaptic transmission and plasticity. Despite in vitro evidence, their causal contribution to cortical network activity and sensory information processing in vivo remains unresolved. Here we report that selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate receptors. Photostimulation of astrocytes in vivo increases the spontaneous firing of parvalbumin-positive (PV+) inhibitory neurons, while excitatory and somatostatin-positive (SOM+) neurons show either an increase or decrease in their activity. Moreover, PV+ neurons show increased baseline visual responses and reduced orientation selectivity to visual stimuli, whereas excitatory and SOM+ neurons show either increased or decreased baseline visual responses together with complementary changes in orientation selectivity. Therefore, astrocyte activation, through the dual control of excitatory and inhibitory drive, influences neuronal integrative features critical for sensory information processing.

Suggested Citation

  • Gertrudis Perea & Aimei Yang & Edward S. Boyden & Mriganka Sur, 2014. "Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo," Nature Communications, Nature, vol. 5(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4262
    DOI: 10.1038/ncomms4262
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    Cited by:

    1. Woo-Hyun Cho & Kyungchul Noh & Byung Hun Lee & Ellane Barcelon & Sang Beom Jun & Hye Yoon Park & Sung Joong Lee, 2022. "Hippocampal astrocytes modulate anxiety-like behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Junli Zhao & Jinyi Sun & Yang Zheng & Yanrong Zheng & Yuying Shao & Yulan Li & Fan Fei & Cenglin Xu & Xiuxiu Liu & Shuang Wang & Yeping Ruan & Jinggen Liu & Shumin Duan & Zhong Chen & Yi Wang, 2022. "Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Zhao, Jinyi & Yu, Ying & Wang, Qingyun, 2022. "Dynamical regulation of epileptiform discharges caused by abnormal astrocyte function with optogenetic stimulation," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    4. Dan Chen & Yong Qi & Jia Zhang & Yunlei Yang, 2022. "Deconstruction of a hypothalamic astrocyte-white adipocyte sympathetic axis that regulates lipolysis in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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