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Minimally invasive detection of cancer using metabolic changes in tumor-associated natural killer cells with Oncoimmune probes

Author

Listed:
  • Deeptha Ishwar

    (Partnership between Ryerson University and St. Michael’s Hospital
    Ryerson University
    Ryerson University
    Ryerson University)

  • Rupa Haldavnekar

    (Partnership between Ryerson University and St. Michael’s Hospital
    Ryerson University
    Ryerson University
    Ryerson University)

  • Krishnan Venkatakrishnan

    (Partnership between Ryerson University and St. Michael’s Hospital
    Ryerson University
    Ryerson University
    Keenan Research Center for Biomedical Science, Unity Health Toronto)

  • Bo Tan

    (Partnership between Ryerson University and St. Michael’s Hospital
    Ryerson University
    Keenan Research Center for Biomedical Science, Unity Health Toronto)

Abstract

Natural Killer (NK) cells, a subset of innate immune cells, undergo cancer-specific changes during tumor progression. Therefore, tracking NK cell activity in circulation has potential for cancer diagnosis. Identification of tumor associated NK cells remains a challenge as most of the cancer antigens are unknown. Here, we introduce tumor-associated circulating NK cell profiling (CNKP) as a stand-alone cancer diagnostic modality with a liquid biopsy. Metabolic profiles of NK cell activation as a result of tumor interaction are detected with a SERS functionalized OncoImmune probe platform. We show that the cancer stem cell-associated NK cell is of value in cancer diagnosis. Through machine learning, the features of NK cell activity in patient blood could identify cancer from non-cancer using 5uL of peripheral blood with 100% accuracy and localization of cancer with 93% accuracy. These results show the feasibility of minimally invasive cancer diagnostics using circulating NK cells.

Suggested Citation

  • Deeptha Ishwar & Rupa Haldavnekar & Krishnan Venkatakrishnan & Bo Tan, 2022. "Minimally invasive detection of cancer using metabolic changes in tumor-associated natural killer cells with Oncoimmune probes," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32308-x
    DOI: 10.1038/s41467-022-32308-x
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    References listed on IDEAS

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    2. Nicolò Maccaferri & Keith E. Gregorczyk & Thales V. A. G. de Oliveira & Mikko Kataja & Sebastiaan van Dijken & Zhaleh Pirzadeh & Alexandre Dmitriev & Johan Åkerman & Mato Knez & Paolo Vavassori, 2015. "Ultrasensitive and label-free molecular-level detection enabled by light phase control in magnetoplasmonic nanoantennas," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
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    4. Rupa Haldavnekar & Krishnan Venkatakrishnan & Bo Tan, 2018. "Non plasmonic semiconductor quantum SERS probe as a pathway for in vitro cancer detection," Nature Communications, Nature, vol. 9(1), pages 1-18, December.
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